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    Glossary Prostaglandin D2

    lipid compound linked to hair loss and inflammation

    Prostaglandin D2 (PGD2) is a type of prostaglandin, which are lipid compounds that have hormone-like effects in the body. PGD2 is involved in various physiological processes, including the regulation of inflammation and allergic responses. Notably, it has been linked to hair growth regulation, where elevated levels of PGD2 in the scalp have been associated with hair loss conditions such as androgenetic alopecia.

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    1. Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis through the Receptor, Gpr44 Journal of Investigative Dermatology · 2012 · 68 citations
    2. In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss Journal of Ethnopharmacology · 2015 · 30 citations
    3. Divergent proliferation patterns of distinct human hair follicle epithelial progenitor niches in situ and their differential responsiveness to prostaglandin D2 Scientific Reports · 2017 · 21 citations
    4. Biochemical and Structural Characteristics, Gene Regulation, Physiological, Pathological and Clinical Features of Lipocalin-Type Prostaglandin D2 Synthase as a Multifunctional Lipocalin Frontiers in Physiology · 2021 · 18 citations
    5. Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2018 · 18 citations
    6. 15-deoxy prostaglandin J2, the nonenzymatic metabolite of prostaglandin D2, induces apoptosis in keratinocytes of human hair follicles: a possible explanation for prostaglandin D2-mediated inhibition of hair growth Naunyn-Schmiedeberg's Archives of Pharmacology · 2016 · 11 citations
    7. Computer-Aided Designing Peptide Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase Combined Molecular Docking and Molecular Dynamics Simulation Molecules · 2023 · 9 citations
    8. Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes Journal of Investigative Dermatology Symposium Proceedings · 2017 · 9 citations
    9. Prostaglandin D2(PGD2); prostaglandin D2 receptor (CRTH2; GPR44; CD294); prostaglandin D2 synthase (PTGDS) Science-business Exchange · 2012 · 2 citations
    10. Expression Level of Prostaglandin D2 Receptor 2 Regulates Hair Regression Journal of Investigative Dermatology · 2019 · 2 citations
    11. 697 Prostaglandin D2-enhanced testosterone metabolism in human keratinocytes is mediated by reactive oxygen species Journal of Investigative Dermatology · 2016 · 1 citations
    12. 699 Effect of Prostaglandin D 2 on hair follicle growth and its impact on hair follicle stem/progenitor cells Journal of Investigative Dermatology · 2016 · 1 citations
    13. Ageratum Conyzoides L. Extract Inhibits 5α-Reductase Gene Expression and Prostaglandin D2 Release in Human Hair Dermal Papilla Cells and Improves Symptoms of Hair Loss in Otherwise Healthy Males and Females in an Open Label Pilot Study Journal of cosmetology & trichology · 2021
    14. Estimation of serum prostaglandin D2 levels and its expression in tissue of Alopecia areata Fayoum University Medical Journal · 2019
    15. 013 Prostaglandin D2 enhances testosterone metabolism by ROS-mediated altered redox potential in keratinocytes Journal of Investigative Dermatology Symposium Proceedings · 2017
    16. Faculty Opinions recommendation of Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2016
    17. Faculty Opinions recommendation of Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2012
    18. Faculty Opinions recommendation of Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2012
    19. A prostaglandind-synthase-positive mast cell gradient characterizes scalp patterning Journal of Cutaneous Pathology · 2013 · 6 citations
    20. Prostaglandin D <sub>2</sub> Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012 · 205 citations
    21. Does prostaglandin D<sub>2</sub> hold the cure to male pattern baldness? Experimental Dermatology · 2014 · 57 citations
    22. Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase Journal of Lipid Research · 2013 · 20 citations
    23. Oral administration of low-dose bisphenol A promotes proliferation of ventral prostate and upregulates prostaglandin D<sub>2</sub> synthase expression in adult rats Toxicology and Industrial Health · 2015 · 14 citations
    24. High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase Acta Crystallographica Section D-biological Crystallography · 2014 · 5 citations
    25. Role of prostaglandins in androgenetic alopecia Prostaglandins & Other Lipid Mediators · 2026
    26. The physiological and pharmacological roles of prostaglandins in hair growth The Korean Journal of Physiology and Pharmacology · 2022
    27. Wound Healing and Skin Regeneration Cold Spring Harbor Perspectives in Medicine · 2015 · 359 citations
    28. Mechanism of action of herbs and their active constituents used in hair loss treatment Fitoterapia · 2016 · 47 citations
    29. New drugs under investigation for the treatment of alopecias Expert Opinion on Investigational Drugs · 2019 · 26 citations
    30. Genetic and molecular aspects of androgenetic alopecia Indian Journal of Dermatology, Venereology and Leprology · 2018 · 24 citations