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    Glossary Prostaglandin D2

    lipid compound linked to hair loss and inflammation

    Prostaglandin D2 (PGD2) is a type of prostaglandin, which are lipid compounds that have hormone-like effects in the body. PGD2 is involved in various physiological processes, including the regulation of inflammation and allergic responses. Notably, it has been linked to hair growth regulation, where elevated levels of PGD2 in the scalp have been associated with hair loss conditions such as androgenetic alopecia.

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    1. Prostaglandin D <sub>2</sub> Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012 · 205 citations
    2. Prostaglandin-Induced Hair Growth Survey of Ophthalmology · 2002 · 162 citations
    3. Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis through the Receptor, Gpr44 Journal of Investigative Dermatology · 2012 · 68 citations
    4. Does prostaglandin D<sub>2</sub> hold the cure to male pattern baldness? Experimental Dermatology · 2014 · 57 citations
    5. Recent Progress in Prostaglandin F<sub>2</sub><i><sub>α</sub></i>Ethanolamide (Prostamide F<sub>2</sub><i><sub>α</sub></i>) Research and Therapeutics Pharmacological reviews · 2013 · 43 citations
    6. Understanding the role of prostaglandin E2 in regulating human platelet activity in health and disease Thrombosis Research · 2015 · 35 citations
    7. In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss Journal of Ethnopharmacology · 2015 · 30 citations
    8. After Skin Wounding, Noncoding dsRNA Coordinates Prostaglandins and Wnts to Promote Regeneration Journal of Investigative Dermatology · 2017 · 27 citations
    9. Divergent proliferation patterns of distinct human hair follicle epithelial progenitor niches in situ and their differential responsiveness to prostaglandin D2 Scientific Reports · 2017 · 21 citations
    10. The prostaglandin synthases, COX-2 and L-PGDS, mediate prostate hyperplasia induced by low-dose bisphenol A Scientific Reports · 2020 · 20 citations
    11. Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase Journal of Lipid Research · 2013 · 20 citations
    12. Biochemical and Structural Characteristics, Gene Regulation, Physiological, Pathological and Clinical Features of Lipocalin-Type Prostaglandin D2 Synthase as a Multifunctional Lipocalin Frontiers in Physiology · 2021 · 18 citations
    13. Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2018 · 18 citations
    14. Oral administration of low-dose bisphenol A promotes proliferation of ventral prostate and upregulates prostaglandin D<sub>2</sub> synthase expression in adult rats Toxicology and Industrial Health · 2015 · 14 citations
    15. HMGB1 promotes hair growth via the modulation of prostaglandin metabolism Scientific Reports · 2019 · 12 citations
    16. 15-deoxy prostaglandin J2, the nonenzymatic metabolite of prostaglandin D2, induces apoptosis in keratinocytes of human hair follicles: a possible explanation for prostaglandin D2-mediated inhibition of hair growth Naunyn-Schmiedeberg's Archives of Pharmacology · 2016 · 11 citations
    17. Expression of NAD+dependent 15-hydroxyprostaglandin dehydrogenase and protection of prostaglandins in human hair follicle Experimental Dermatology · 2008 · 11 citations
    18. Computer-Aided Designing Peptide Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase Combined Molecular Docking and Molecular Dynamics Simulation Molecules · 2023 · 9 citations
    19. Phosphodiesterase inhibitors and prostaglandin analogues in dermatology: A comprehensive review Dermatologic Therapy · 2020 · 9 citations
    20. Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes Journal of Investigative Dermatology Symposium Proceedings · 2017 · 9 citations
    21. No genetic support for a contribution of prostaglandins to the aetiology of androgenetic alopecia British Journal of Dermatology · 2013 · 7 citations
    22. A prostaglandind-synthase-positive mast cell gradient characterizes scalp patterning Journal of Cutaneous Pathology · 2013 · 6 citations
    23. High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase Acta Crystallographica Section D-biological Crystallography · 2014 · 5 citations
    24. Prostaglandins: Key players in immunomodulation of the nervous system Neural Regeneration Research · 2025 · 3 citations
    25. Expression Level of Prostaglandin D2 Receptor 2 Regulates Hair Regression Journal of Investigative Dermatology · 2019 · 2 citations
    26. Prostaglandin D2(PGD2); prostaglandin D2 receptor (CRTH2; GPR44; CD294); prostaglandin D2 synthase (PTGDS) Science-business Exchange · 2012 · 2 citations
    27. 699 Effect of Prostaglandin D 2 on hair follicle growth and its impact on hair follicle stem/progenitor cells Journal of Investigative Dermatology · 2016 · 1 citations
    28. Enhancement of hair growth through stimulation of hair follicle stem cells by prostaglandin E2 collagen matrix Experimental cell research · 2022 · 1 citations
    29. 697 Prostaglandin D2-enhanced testosterone metabolism in human keratinocytes is mediated by reactive oxygen species Journal of Investigative Dermatology · 2016 · 1 citations
    30. Ageratum Conyzoides L. Extract Inhibits 5α-Reductase Gene Expression and Prostaglandin D2 Release in Human Hair Dermal Papilla Cells and Improves Symptoms of Hair Loss in Otherwise Healthy Males and Females in an Open Label Pilot Study Journal of cosmetology & trichology · 2021