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The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

Finasteride may cause slight depression and anxiety.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Female pattern hair loss has unclear causes, possibly involving genetics, hormones, and environment, and needs better treatments.

The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.

Treating hirsutism in women often requires a mix of medications and cosmetic methods for best results.

Certain genetic markers linked to reproductive potential were identified by their impact on a protein's ability to bind to genes.

Testosterone makes the connections in the uterus lining simpler and lowers certain protein levels, which might lead to infertility.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

The document explains how to create detailed biological pathways using genomic data and tools, with examples of hair and breast development.

Altered metabolism can help control seizures by changing brain signaling and energy use, suggesting new treatments for epilepsy.

Finasteride treats hair loss but may cause low libido, erectile issues, and depression.

MK-2206 was safe and effectively blocked AKT signaling in cancer patients, warranting more trials.

CRH in the skin acts like the body's stress response system, affecting cell behavior and immune activity.

Vitamin D is important for bones, hair, blood pressure, and breast development.

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

Increased ODC activity leads to skin tumors by recruiting stem cells, not by toxic byproducts.

Androgens like testosterone may help treat traumatic brain injury by reducing mitochondrial stress and inflammation.

Eating a Mediterranean diet and taking certain supplements may improve symptoms of PCOS.

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

Cells lacking the Bax protein can outcompete others, leading to better tissue repair and hair growth.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.