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PCOS is a hormonal disorder causing symptoms like irregular periods and acne, and increases the risk of diabetes and heart disease.

Hormone imbalance is linked to Hidradenitis Suppurativa, a skin condition, and treatments like anti-androgenic therapy and metformin can help. It's also suggested to check patients for insulin resistance and Polycystic Ovary Syndrome.

Microglia, the brain's immune cells, may contribute to Polycystic Ovary Syndrome (PCOS) by altering the female brain's structure and function, with kisspeptin neurons and GABA neurotransmitters also playing a role.

A new compound effectively inhibits human 5α-reductase 1.

Drospirenone is a unique progestin with anti-water retention and potential blood pressure benefits, used in birth control and hormone therapy.

High doses of testosterone disrupt hormone levels and receptor expression in the uterus, affecting fertility.

A natural steroid in the body may protect against eye damage in glaucoma.

Spironolactone helps reduce hospital visits and death from heart issues, lowers blood pressure, but has unclear effects on heart failure with normal heart pump function and can cause high potassium and breast enlargement in men.

Kelulut Honey can help regulate sex hormone receptors in rats with Polycystic Ovary Syndrome, similar to common medications.

The length of CAG repeats in the androgen receptor gene is linked to ovarian reserve but does not affect how the ovaries respond to stimulation.

Certain genetic variations in the AR and ERβ genes can affect androgen levels in women.

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

Progesterone boosts alcohol's effect on brain, finasteride counters it.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

Finasteride blocks progesterone's effect on absence seizures in rats.

Estrogens and progesterone are key in regulating melasma pigmentation.

Spironolactone can cause side effects like irregular bleeding, but lower doses may reduce these effects and still improve hirsutism.

Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.

Drugs targeting the Androgen Receptor are effective for treating prostate cancer and other androgen-related conditions.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

Hair diversity is influenced by complex genetics and environmental factors, requiring more research for practical solutions.

Many treatments for hair loss lack proper testing and FDA approval, so their effectiveness is uncertain.

The study created a test that found hormonal and toxic effects in plant and fungal extracts using prostate cancer cells.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

ERβ has potential in treating prostate cancer and neurodegenerative diseases, but human studies are needed before clinical use.

COVID-19 may worsen with androgens; anti-androgen drugs could help.

The document concludes that combination therapy is most effective for treating excessive hair growth in women with idiopathic hirsutism, and more research is needed to understand the condition.