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PCOS is a complex condition in women that can lead to health issues, and lifestyle changes are the best management approach.

Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.

Melasma's causes include genetics, sun exposure, hormones, and oxidative stress, and understanding these can help create better treatments.

The compounds tested could potentially treat hair loss and alopecia.

The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Treating non-classic congenital adrenal hyperplasia is complex because the benefits of hormone treatment must be weighed against potential health risks.

The conclusion is that obesity should be managed with a slow, balanced approach to diet and exercise, with medication and surgery as additional options, and education and access to care are important.

Cirrhosis affects quality of life with various symptoms, requiring a holistic, multidisciplinary approach for management.

New tools show that in fish, NPY increases feeding and somatostatin decreases it.

A misdiagnosed case of HAIR-AN syndrome led to unnecessary surgeries and highlighted the importance of correct diagnosis and treatment.

Compound 7b is a promising candidate for treating benign prostatic hyperplasia and prostate cancer.

Sex steroids, especially progesterone, can slow down the growth of mouse melanoma cells.

Bolandiol, a synthetic steroid, builds muscle and bone without greatly affecting sex glands, and works differently from other hormones.

Patients with advanced breast cancer and high hormone receptor levels who had surgery for ovarian/pelvic metastases lived longer, especially if they had high estrogen receptor levels.

Fulvestrant is a well-tolerated new treatment for advanced breast cancer that may delay chemotherapy.

Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.

Megestrol acetate helps fat-derived stem cells grow, move, and turn into fat cells through a specific receptor.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Allopregnanolone increases growth and changes gene activity in human brain cancer cells.

Finasteride slows down motherly behavior in first-time pregnant rats.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

Inactive hair follicle stem cells help prevent skin cancer.

The conclusion is that the best initial treatment for hirsutism is usually oral contraceptives, with the addition of antiandrogens or insulin sensitizers if needed, and topical eflornithine or laser treatments as supplementary options.

The document concludes that lifestyle changes and medical treatments can significantly reduce symptoms of Hidradenitis Suppurativa, a chronic skin condition.

Vitamin D and estrogen may help protect heart and kidney health, and maintaining sufficient vitamin D levels could be especially beneficial for African Americans, postmenopausal women, and people with chronic kidney disease.

Dihydrotestosterone increases growth and spread of human brain cancer cells, and blocking its formation might help treat this cancer.

Molecular diagnostics help identify genetic defects causing endocrine diseases, improving diagnosis and treatment options.