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In this study, IFN-γ-stimulated iPSC-derived mesenchymal stem cell extracellular vesicles improved atopic dermatitis in mice by reducing Th2 cytokine activity, suppressing inflammation, and restoring skin barrier function, as evidenced by decreased itching and inflammatory markers.

This study explored the wound healing potential of a natural marine soft coral-derived nanoparticle-based gel in a diabetic excision wound model, finding it effectively regulates proinflammatory cytokines and inhibits enzymes related to wound healing.

This study explores the regulatory effects of ursolic acid on macrophage function and suggests potential for developing new anti-inflammatory and immunomodulatory drugs, though further research is needed for clinical applications.

This study found that in a mouse model of psoriasis, depleting CD169⁺ macrophages led to milder symptoms and decreased inflammation, suggesting these macrophages play a crucial role in psoriasis development.

This study suggests that allogenic human mesenchymal stem cell treatments have potential therapeutic effects by inducing immune tolerance and anti-inflammatory effects in severe alopecia areata patients.

In this study, the researchers identified MJ04, a selective JAK3 inhibitor, as a promising candidate for promoting hair growth, demonstrating efficacy in both animal models and human hair follicle assays with a favorable safety and pharmacokinetic profile.

In a mouse model study, transcutaneous auricular vagus nerve stimulation (taVNS) significantly reduced depigmentation in vitiligo, potentially through mechanisms that regulate oxidative stress and inflammation, indicating taVNS's promise as a therapeutic approach for this skin disorder.

This study discovered that TREM2 macrophages influenced by squalene play a role in acne's development by hindering the killing of Cutibacterium acnes, helping explain why benzoyl peroxide is effective in treatment.

In this study, researchers investigated the penetration and cellular responses to nanoplastics in human skin models with compromised barriers, finding that nanoplastics can penetrate the skin, accumulate in cells, and trigger inflammatory responses through specific signaling pathways.

In this study, researchers observed an increased incidence of pattern hair loss and telogen effluvium among COVID-19 patients, potentially linked to psychological stress, systemic inflammation, and oxidative stress, with reduced anagenic expression of proteoglycans suggested as a mediating mechanism.

This study found that TRPV3 ion channels on human epidermal keratinocytes suppress cell proliferation, induce cell death, and trigger a proinflammatory response, suggesting a role in cutaneous inflammatory processes.

This study established a new mouse model for TCE-induced skin sensitization and reported that proinflammatory cytokines TNF-α, IFN-γ, and IL-2 significantly contribute to this sensitization process.

This study found that TRPV3 activation in human sebocytes inhibits lipid synthesis and triggers proinflammatory cytokine expression, suggesting a role in the pathogenesis of dry skin-associated inflammatory dermatoses.

This study found that dermal adipocytes contribute to efficient skin repair by releasing fatty acids that recruit macrophages and transforming into myofibroblasts that aid wound healing.

This study found that in a neonatal rat model, skin wounding protected against chemotherapy-induced alopecia through IL-1β signaling, making hair follicles more resistant to damage when wounding exposure was timed correctly.

This study found that dutasteride may help prevent enteric neuronal damage in an animal model of Parkinson's disease, highlighting its potential for drug repurposing to address neuroinflammation.

This review discusses the role of keratinocytes in hidradenitis suppurativa, highlighting their genetic and metabolic influences on disease progression without presenting new clinical results.

In a mouse model study, researchers observed that the absence of MCPIP1 in myeloid cells decreased susceptibility to chemically induced skin papillomas but caused significant hair loss and skin pigmentation changes, suggesting a role for MCPIP1 in skin carcinogenesis and follicle integrity.

In this review, the authors detailed the clinical, trichoscopic, and histopathological features of hair disorders linked to autoimmune diseases, highlighting the role of dermatologists in identifying possible underlying autoimmune conditions in patients presenting with hair loss.

This study found that women with PCOS had significantly higher levels of the pro-inflammatory chemokine MIP-1α compared to controls, suggesting an association with low-grade chronic inflammation, though the increase in MIP-1β levels did not reach statistical significance.

This study found that mechlorethamine restored hair growth in mice with alopecia-areata-like disease by eliminating infiltrated lymphocytes and inhibiting certain pro-inflammatory cytokines in treated skin areas.

In this study, the researchers reported that patient impacts and symptoms of hidradenitis suppurativa, as assessed by HSIA and HSSA measures, are associated with clinical characteristics such as the number of abscesses and inflammatory nodules.

This case report describes a 25-year-old woman with widespread lichen planus who did not respond to multiple systemic treatments, including antihistamines, hydroxychloroquine sulfate, and corticosteroids.

This study found that injectable gelatin/metal/tea polyphenol double nanonetworks significantly accelerated wound healing in diabetic wounds by enhancing cell migration and providing anti-inflammatory and antioxidant properties, without detectable cytotoxicity in tests.

In this review, the authors discuss various skin conditions linked to hyperandrogenism, such as acne and alopecia, with a focus on androgen-targeted therapies, suggesting these are generally more effective than non-androgen-targeted options.

Generalized glucocorticoid resistance causes hormone imbalances and varied symptoms due to gene mutations.

The document explains various skin conditions and their treatments.

This review highlights advances in understanding inflammatory memory in epidermal stem cells, focusing on their capacity to remember prior inflammatory responses and respond more quickly to future stimuli, potentially aiding strategies against skin-related diseases.

This review examines the use of monoaminergic antidepressants for inflammatory skin disorders and reports they may reduce dermatological symptoms, suggesting a potential role beyond treating psychiatric conditions.

This study found that soluble CD83 (sCD83) accelerated chronic and hard-to-heal wound healing and improved inflammatory and pro-resolving cytokine profiles, suggesting potential for therapeutic use.