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In this review, researchers explore the roles of lactoferrin in skin and hair health, highlighting its potential anti-inflammatory and regenerative benefits despite the lack of well-controlled clinical trials for hair-specific outcomes.

This review compiled evidence suggesting that flavonoids may promote skin wound healing due to their anti-inflammatory, angiogenesis, re-epithelialization, and antioxidant properties, while also discussing current limitations and future prospects for these compounds as wound-healing agents.

This study found that 3D-printed polyamine-modified hydrogels facilitate M2 macrophage polarization and exosome secretion, enhancing skin cell compatibility and promoting wound healing and hair follicle induction in an animal model through specific signaling pathways, suggesting potential for skin disorder therapies.

This study found that monocytes/macrophages with a pro-inflammatory M1-like phenotype may play a crucial role in the pathogenesis of hidradenitis suppurativa, suggesting potential therapeutic targets.

This study investigated chitosan–hydroxyapatite biocomposites, finding them to enhance anti-inflammatory cytokine expression, support cellular activities, and reduce pro-inflammatory cytokines in a dermatitis model, while highlighting gaps in understanding their immune modulation and issues with reproducibility for clinical use.

This study found that FGF21 suppresses inflammation induced by C. acnes in both human skin cells and mouse models, suggesting potential use in acne treatment.

This review explores the hormonal factors related to hidradenitis suppurativa, emphasizing insulin resistance and pro-inflammatory adipokines, but reports no new clinical findings and suggests further research is needed.

This study found that alopecia areata is linked to genetic factors, specifically HLA haplotypes on chromosome 6, and involves immune privilege collapse at hair follicles which is mediated by the JAK-STAT pathway and pro-inflammatory cytokines like IFN-γ.

This review discusses how ionizing radiation causes skin damage by inducing cellular senescence in keratinocytes, which secrete inflammatory mediators, recruiting immune cells and exacerbating inflammation, impacting the skin barrier function and healing.

In this source, recent single-cell RNA-sequencing advances reveal significant transcriptional heterogeneity among skin fibroblasts, and the discussion focuses on the distinct subtypes' roles in skin homeostasis, repair, and their evolution in fibrotic diseases like keloid scars and cancer.

The researchers reported that targeting glycoprotein 130's signaling site in animal models promoted tissue regeneration and reduced osteoarthritis progression through anti-inflammatory and protective effects.

Alopecia totalis/universalis involves more intense immune activity and inflammation than patchy alopecia areata.

This study suggests that extracellular vesicles derived from Saccharomyces cerevisiae may enhance hair follicle-related cellular processes, highlighting their potential for biomedical and cosmetic applications.

This review explores current knowledge on fibroblast lineage specification and its impact on scar-free wound healing, noting that early fetal skin fibroblasts support regeneration, while later developmental shifts lead to fibrosis, highlighting potential strategies to reprogram adult fibroblasts for regenerative repair.

This study found that patients with patchy alopecia areata had significantly higher serum levels of pro-inflammatory cytokines IL-6, TNF-α, IL-17A, and IL-21 compared to healthy controls, with these levels correlating positively with disease severity, age, and disease duration.

This study found that Annexin A5 significantly reduced fibrosis and inflammation in both preventive and therapeutic contexts in a bleomycin-induced localized scleroderma mouse model, demonstrating its potential anti-fibrotic and anti-inflammatory effects for treating fibrotic diseases.

This study found that oxyresveratrol enhanced cell proliferation, reduced oxidative stress and inflammation in vitro, and promoted hair growth in an androgenetic alopecia mouse model, suggesting its potential as a treatment for hair loss.

This study found that specific TRPM5 modulators are unlikely to directly affect sebaceous glands, but safe TPPO analogues may provide moderate lipogenic and anti-inflammatory effects beneficial for dry skin conditions.

This study found that hair follicle stem cell-derived secretome mitigated cell death, apoptosis, and inflammation while upregulating neurotrophic factors in astrocytes exposed to oxygen-glucose deprivation, an in vitro ischemic stroke model, suggesting potential therapeutic benefits in stroke recovery.

This study observed that a novel extracellular matrix hydrogel made from human fibroblast-derived matrix improved wound healing in animal models, showing significant effects such as hair follicle formation, reduced inflammation, enhanced pro-healing growth factor levels, and interaction with macrophages, compared to traditional collagen hydrogels.

This study found increased infiltration of specific immune cells, such as γδ T cells and CD8+ T cells, in the bald scalp of male androgenetic alopecia patients, and identified four key immune-related genes potentially involved in hair loss development through interferon-γ signaling pathways.

This review compiles existing knowledge on the mechanisms and diagnosis of various types of hair loss following COVID-19, including telogen effluvium and alopecia areata, and emphasizes the need to educate patients on these conditions.

This study found that UV radiation-induced fibroblast depletion in the skin is primarily due to a deregulated inflammatory response, with T cells aiding fibroblast survival under stress.

This study found that glycyrrhetinic acid, derived from licorice, may help alleviate acne symptoms by regulating lipid synthesis and inflammatory responses through multiple pathways, as observed in both in vitro and in vivo settings.

This study reported that in mice with rapamycin-induced thymic atrophy, Angelica sinensis promoted thymic cortical regeneration and functional recovery by activating the Wnt/CTNNB1/Foxn1 signaling pathway and improving inflammatory microenvironment, suggesting its potential benefit against immune aging.

In this study, transgenic mice overexpressing the glucocorticoid receptor in certain epithelia showed skin development abnormalities resembling ectodermal dysplasia and exhibited reduced inflammatory responses.

This study introduced a bioengineered model that simulates acne's microenvironment in mice, enabling the exploration of host and P. acnes interactions and presenting a novel platform for anti-acne drug and vaccine screening.

This review highlights that current diagnostic and treatment methods for chronic pelvic pain syndrome lack robust evidence, suggesting a need for further research.

This study found no significant differences in certain proinflammatory protein levels between patients with alopecia areata and healthy controls but noted a potential association between disease severity and increased atherosclerosis risk.

This review discusses botulinum toxin A as a treatment for various types of hair loss and reports no clinical results; the authors emphasize the need for comprehensive evaluations and further research.