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    Glossary Primary Hair Follicles

    initial hair-producing structures formed during fetal development

    Primary hair follicles are the initial hair-producing structures that develop in the skin during fetal development. These follicles typically give rise to thicker, coarser hairs, such as those found on the scalp, eyebrows, and eyelashes. They are distinct from secondary hair follicles, which produce finer, shorter hairs like those on the body and face.

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    1. Comparative Transcriptome Analysis Reveals that a Ubiquitin-Mediated Proteolysis Pathway Is Important for Primary and Secondary Hair Follicle Development in Cashmere Goats PLoS ONE · 2016 · 31 citations
    2. Neural, adipocyte and hepatic differentiation potential of primary and secondary hair follicle stem cells isolated from Arbas Cashmere goats BMC veterinary research · 2022 · 2 citations
    3. A 4kb Fragment of the Desmocollin 3 Promoter Directs Reporter Gene Expression to Parakeratotic Epidermis and Primary Hair Follicles Journal of Investigative Dermatology · 2006 · 1 citations
    4. Effects of Estradiol on Culture in vitro of Cashmere Goat Primary Hair Follicles Anhui nongye kexue · 2009
    5. 773 Generation of human hair follicle organoids in vitro and ex vivo by co-culture of primary human hair matrix keratinocytes and dermal papilla fibroblasts Journal of Investigative Dermatology · 2020
    6. Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632 Frontiers in cell and developmental biology · 2021 · 16 citations
    7. HAIR FOLLICLE STEM CELLS IN THE PATHOGENESIS OF PRIMARY CICATRICIAL ALOPECIA Zagazig University Medical Journal · 2015
    8. Does collapse of immune privilege in the hair-follicle bulge play a role in the pathogenesis of primary cicatricial alopecia? Clinical and Experimental Dermatology · 2009 · 39 citations
    9. Comparative spatial transcriptomics of hair follicle-T cell interactions in mouse, dog and human reveals conserved drivers of primary cicatricial alopecia bioRxiv (Cold Spring Harbor Laboratory) · 2025
    10. Dengue Virus Infects Primary Human Hair Follicle Dermal Papilla Cells Frontiers in Cellular and Infection Microbiology · 2018 · 14 citations
    11. Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro European Journal of Cell Biology · 2010 · 42 citations
    12. [Primary observation on construction of skin with human hair follicle bulge cells with tissue engineering technique]. PubMed · 2007 · 4 citations
    13. Corrigendum to “Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro” [Eur. J. Cell Biol. (2010) 769–777] European Journal of Cell Biology · 2012 · 1 citations
    14. Extracellular vesicles released by hair follicle and adipose mesenchymal stromal cells induce comparable neuroprotective and anti-inflammatory effects in primary neuronal and microglial cultures Cytotherapy · 2023
    15. The cause of primary and secondary damage to hair follicles on full thickness skin autografts Archives of Dermatological Research · 1974 · 2 citations
    16. Efficient establishment of an optimized culture condition for cashmere goat primary hair follicle stem cells 2023
    17. Transcriptome Sequencing Reveals Differences between Primary and Secondary Hair Follicle-derived Dermal Papilla Cells of the Cashmere Goat (Capra hircus) PLoS ONE · 2013 · 81 citations
    18. Influences of IGF-1 and EGF on primary hair follicles of Liaoning cashmere goat in vitro. Shenyang Nongye Daxue xuebao · 2010 · 1 citations
    19. Effects of Estradiol on Cashmere Goat Primary Hair Follicles Cultured in vitro 农业科学与技术(英文版) · 2008
    20. Faculty Opinions recommendation of Nonviral in situ green fluorescent protein labeling and culture of primary, adult human hair follicle epithelial progenitor cells. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2009
    21. 726 The Wnt-inhibitor Dkk4 is required for primary hair follicle induction and patterning Journal of Investigative Dermatology · 2022
    22. 318 The Wnt-inhibitor Dkk4 is required for primary hair follicle induction and patterning Journal of Investigative Dermatology · 2021
    23. Nonviral in Situ Green Fluorescent Protein Labeling and Culture of Primary, Adult Human Hair Follicle Epithelial Progenitor Cells Stem Cells · 2009 · 43 citations
    24. LHX2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth Development · 2016 · 43 citations
    25. Fibroblast growth factor 5-short (FGF5s) inhibits the activity of FGF5 in primary and secondary hair follicle dermal papilla cells of cashmere goats Gene · 2015 · 42 citations
    26. Comprehensive analysis of the expression profiles of mRNA, lncRNA, circRNA, and miRNA in primary hair follicles of coarse sheep fetal skin BMC Genomics · 2024 · 13 citations
    27. A Simple In Vivo System for Studying Epithelialization, Hair Follicle Formation, and Invasion Using Primary Epidermal Cells from Wild-Type and Transgenic Ornithine Decarboxylase-Overexpressing Mouse Skin Journal of Investigative Dermatology · 2001 · 13 citations
    28. Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats PLoS ONE · 2016 · 127 citations
    29. Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling ˜The œAmerican journal of pathology · 2004 · 65 citations
    30. The role of prolactin in the reactivation of hair follicles in relation to moulting in cashmere goats 1994 · 62 citations