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    Glossary Premature Senescence

    early cellular aging causing permanent growth arrest

    Premature senescence refers to the early onset of cellular aging, where cells stop dividing and enter a state of permanent growth arrest earlier than expected. This can be triggered by various stress factors such as DNA damage, oxidative stress, or chronic inflammation, and is often associated with conditions like alopecia, where hair follicles may stop functioning properly, leading to hair loss.

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    1. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated with p16INK4a Expression Journal of Investigative Dermatology · 2007 · 141 citations
    2. Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage PLOS ONE · 2013 · 30 citations
    3. 803 Taxane chemotherapy induces epigenetic changes and premature senescence in human scalp hair follicles Journal of Investigative Dermatology · 2024
    4. Embryonic NIPP1 depletion in keratinocytes triggers a cell-cycle arrest and premature senescence in adult mice Journal of Investigative Dermatology · 2024
    5. Stress-induced premature senescence of dermal papilla cells compromises hair follicle epithelial-mesenchymal interaction Journal of Dermatological Science · 2017 · 35 citations
    6. 517 Regulation of the lipidome and lipid metabolism in prematurely senescent human dermal fibroblasts Journal of Investigative Dermatology · 2022
    7. 559 Induction of tissue-specific premature stem cell aging promotes senescence-like phenotypes in remote multiple organs Journal of Investigative Dermatology · 2022
    8. Androgenic Alopecia and Stress-Induced Premature Senescence by Cumulative Ultraviolet Light Exposure Exogenous Dermatology · 2002 · 27 citations
    9. β-Catenin Signaling Evokes Hair Follicle Senescence by Accelerating the Differentiation of Hair Follicle Mesenchymal Progenitors Frontiers in Cell and Developmental Biology · 2022 · 12 citations
    10. Cellular senescence and polycystic ovary syndrome: mechanisms and therapeutic strategies from a new perspective Annals of Medicine · 2025 · 2 citations
    11. Oxidative stress in ageing of hair International Journal of Trichology · 2009 · 126 citations
    12. Hair Follicle Stem Cell Faith Is Dependent on Chromatin Remodeling Capacity Following Low-Dose Radiation Stem cells · 2017 · 13 citations
    13. Guava (Psidium guajava L.) Leaf Extract as Bioactive Substances for Anti-Androgen and Antioxidant Activities Plants · 2022 · 7 citations
    14. Knockout of p16INK4a promotes aggregative growth of dermal papilla cells Revista Da Associacao Medica Brasileira · 2017 · 2 citations
    15. Immunohistochemical Patterns in the Interfollicular Caucasian Scalps: Influences of Age, Gender, and Alopecia BioMed Research International · 2013 · 8 citations
    16. Oxidative Stress–Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015 · 93 citations
    17. Camellia japonica seed extract promotes hair growth by preventing dermal papilla cell senescence and activating hair follicle stem cells Biotechnology and Bioprocess Engineering · 2025
    18. Targeting IGF1‐Induced Cellular Senescence to Rejuvenate Hair Follicle Aging Aging Cell · 2025
    19. Premature aging syndromes: From patients to mechanism Journal of dermatological science · 2019 · 29 citations
    20. Cellular Senescence and Aging in Myotonic Dystrophy International Journal of Molecular Sciences · 2022 · 4 citations
    21. 0950 Exploring hair aging through ex vivo induction of DNA damage and senescence Journal of Investigative Dermatology · 2025
    22. 1380 Ganoderma lucidum extract attenuates Corticotropin-Releasing Factor (CRF)-induced cellular senescence in human hair follicular cells Journal of Investigative Dermatology · 2023
    23. 1349 Inducing fate changes at the hair follicle stem cell nice Journal of Investigative Dermatology · 2023
    24. Mechanical Stretching Can Modify the Papillary Dermis Pattern and Papillary Fibroblast Characteristics during Skin Regeneration Journal of Investigative Dermatology · 2022 · 19 citations
    25. Perspectives in dermatopathology: telomeres and telomerase in ageing and cancer; with emphasis on cutaneous disease Journal of Cutaneous Pathology · 2000 · 11 citations
    26. Niacinamide Down-Regulates the Expression of DKK-1 and Protects Cells from Oxidative Stress in Cultured Human Dermal Papilla Cells Clinical, Cosmetic and Investigational Dermatology · 2021 · 1 citations
    27. Replicative stress, stem cells and aging Mechanisms of Ageing and Development · 2008 · 70 citations
    28. miR-29 is an important driver of aging-related phenotypes bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 2 citations
    29. Combatting ageing in dermal papilla cells and promoting hair follicle regeneration using exosomes from human hair follicle dermal sheath cup cells Experimental Dermatology · 2023
    30. Lamins in development, tissue maintenance and stress EMBO reports · 2012 · 64 citations