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    Glossary Premature Ovarian Failure

    ovaries stop functioning normally before age 40, causing infertility

    Premature Ovarian Failure (POF), also known as Primary Ovarian Insufficiency, is a condition where a woman's ovaries stop functioning normally before the age of 40. This leads to reduced production of estrogen and other hormones, causing irregular or absent menstrual periods, infertility, and symptoms similar to menopause, such as hot flashes and vaginal dryness.

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    1. Comparison of CD146 +/− mesenchymal stem cells in improving premature ovarian failure Stem Cell Research & Therapy · 2022 · 31 citations
    2. Permanent chemotherapy-induced nonscarring alopecia and premature ovarian failure Clinical and Experimental Dermatology · 2015 · 5 citations
    3. The characterization of patients with premature ovarian failure, endometriosis, and polycystic ovary syndrome in women attending comprehensive health centers in Urmia, Iran BMC Women s Health · 2026
    4. SAT-214 Satoyoshi Syndrome: A Rare Cause of Premature Ovarian Failure Journal of the Endocrine Society · 2019 · 3 citations
    5. Androgen Replacement in Women: A Commentary The Journal of Clinical Endocrinology and Metabolism · 1999 · 99 citations
    6. Androgens and Female Sexual Function and Dysfunction—Findings From the Fourth International Consultation of Sexual Medicine The Journal of Sexual Medicine · 2016 · 75 citations
    7. The therapeutic use of androgens in women The Journal of Steroid Biochemistry and Molecular Biology · 1999 · 51 citations
    8. The rationale for physiological testosterone replacement in women Baillière's clinical endocrinology and metabolism · 1998 · 28 citations
    9. Testosterone Therapy in Premenopausal Women Seminars in Reproductive Medicine · 2006 · 10 citations
    10. Disorders of ovulation Women's Health Medicine · 2006 · 2 citations
    11. Targeting the ovary in female patients with alopecia areata Journal of the American Academy of Dermatology · 2012
    12. Social selection favours offspring prone to the development of androgenetic alopecia. PubMed · 2018
    13. Human hair follicle-derived mesenchymal stem cells improve ovarian function in cyclophosphamide-induced POF mice Stem Cell Research & Therapy · 2025 · 7 citations
    14. Current evaluation of amenorrhea Fertility and Sterility · 2008 · 78 citations
    15. Current evaluation of amenorrhea Fertility and Sterility · 2006 · 38 citations
    16. Frontal fibrosing alopecia: Iatrogenic endocrine disruption Journal of the American Academy of Dermatology · 2015
    17. Sexuality in premature ovarian insufficiency Climacteric · 2019 · 32 citations
    18. Is there a relationship between premature gray hair and other autoimmune phenomena with diminished ovarian reserve? Fertility and Sterility · 2012
    19. EFFECT OF PLATELET-RICH PLASMA IN CYCLOPHOSPHAMIDE-INDUCED OVARIAN FAILURE IN ALBINO RATS: HISTOLOGICAL AND ANATOMICAL STUDY The Egyptian Journal of Histology · 2021 · 2 citations
    20. Progress in research on the effects of Platelet-Rich Plasma (PRP) ovarian injection on early ovarian reserve dysfunction and premature ovarian insufficiency Journal of Ovarian Research · 2026
    21. The mechanisms of MicroRNA 21 in premature ovarian insufficiency mice with mesenchymal stem cells transplantation Journal of Ovarian Research · 2024 · 5 citations
    22. β-sitosterol in Yijing Hugui decoction prevents cyclophosphamide-induced premature ovarian insufficiency via the AKT1/Nrf2 pathway Cytotechnology · 2025 · 7 citations
    23. Current evaluation of amenorrhea Fertility and Sterility · 2004 · 30 citations
    24. Current evaluation of amenorrhea Fertility and Sterility · 2004 · 21 citations
    25. Diagnosis and Challenges of Polycystic Ovary Syndrome in Adolescence Seminars in Reproductive Medicine · 2014 · 30 citations
    26. 6 Current concepts of polycystic ovary syndrome Baillière's clinical obstetrics and gynaecology · 1997 · 60 citations
    27. Cellular senescence and polycystic ovary syndrome: mechanisms and therapeutic strategies from a new perspective Annals of Medicine · 2025 · 2 citations
    28. Prenatal Exposure to Delta-9-tetrahydrocannabinol (THC) Alters the Expression of miR-122-5p and Its Target Igf1r in the Adult Rat Ovary International Journal of Molecular Sciences · 2022 · 9 citations
    29. Microbial harmony in female reproductive health: exploring the impact of intestinal flora on ovarian function and disease pathogenesis American Journal of Translational Research · 2024 · 5 citations
    30. A Comprehensive Review of Management of Patients with Infertility having Polycystic Ovarian Syndrome AMEI's Current Trends in Diagnosis & Treatment · 2026