February 2024 in “Genes to Cells” This study observed that tooth loss in mice led to premature graying of hair in the interbrow region, which was possibly due to reduced stimulation of the trigeminal nerve, suggesting that decreased mastication could cause this type of hair graying.
August 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This paper proposes an integrated model suggesting that psychological stress, sleep disturbances, nutrition, lifestyle, and various biological factors collectively influence hair health, including hair loss and premature greying.
August 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study synthesizes evidence on the complex interplay between stress, sleep, nutrition, lifestyle, and systemic health and their impact on hair health, encompassing premature greying, hair loss, and follicle cycling.
1 citations
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September 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that stress-induced inactivation of the enzyme Dicer in melanocytes can cause premature hair greying by preventing proper melanocyte placement and melanin transfer in mice, suggesting the Dicer-miR92b-ItgaV pathway as an important link between stress and grey hair.
April 2016 in “Medical Acupuncture” This article discusses practices for treating premature hair loss in women, and reports no new experimental results.
20 citations
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October 2017 in “Stem Cell Reports” This study found that loss of the ACER1 gene in mice led to increased ceramide levels and progressive hair loss, highlighting ACER1's role in maintaining hair follicle stem cell homeostasis.
11 citations
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March 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that hair loss in an Olmsted syndrome mouse model with a Trpv3 mutation was linked to premature keratinocyte maturation, affecting hair follicle structure and function.
92 citations
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June 2005 in “Journal of Investigative Dermatology” This study found that the retinoid all-trans retinoic acid induced a catagen-like stage in human scalp hair follicles, suggesting upregulation of TGF-beta2 as a contributing mechanism.
55 citations
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October 1992 in “Archives of Dermatology” In this study, researchers observed that loose anagen hair syndrome is an autosomal dominant disorder characterized by abnormal hair follicle structure and premature keratinization, possibly due to signaling and desmosomal component disturbances.
26 citations
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June 2016 in “Pediatric Dermatology” This study found that premature hair graying in young Turkish men and women is associated with emotional stress, alcohol consumption, chronic diseases, and a family history of graying.
December 2023 in “International Journal of Science and Research (IJSR)” This review article reports that many herbal drugs show potential for treating alopecia effectively and with fewer side effects compared to synthetic drugs, addressing a common issue among urban residents due to stress and environmental factors.
20 citations
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July 2005 in “Experimental dermatology” This study found that the fuzzy mutation in mice is linked to both structural hair defects and accelerated hair follicle cycling, influencing the regulation of hair cycle phases such as catagen and anagen.
July 2007 in “Cancer biology & therapy” In this study, researchers found that deleting the ATR gene in adult mice led to signs of premature aging and reduced capacity for tissue renewal.
12 citations
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May 2019 in “Journal of cosmetic dermatology” This review explores the factors contributing to premature graying of hair, highlighting the role of genetic and environmental influences such as oxidative stress, and discusses potential interventions like diet and herbal remedies, while noting the limitations of common treatments like hair dyes.
134 citations
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December 2018 in “Dermatology and Therapy” This review discusses the potential role of vitamins and minerals in managing non-scarring alopecia but reports no clinical results; the authors advocate for further controlled trials to explore these relationships.
42 citations
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July 2012 in “PLOS ONE” This study found that estrogen can cause reversible suppression of the hair cycle by inducing premature catagen and maintaining the telogen phase without damaging the hair follicle stem cell niche or the signature gene expressions of dermal papilla cells.
9 citations
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February 2020 in “Journal of Cosmetic Dermatology” In this study, CRH receptor antagonists from Pulsatilla chinensis reversed stress hormone-induced changes in hair follicles and dermal papilla cells in a lab setting, suggesting potential pharmaceutical and cosmetic applications for treating stress-related hair loss.
31 citations
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September 2013 in “Stem Cells” This study suggests that canonical BMP signaling, particularly involving Smad1 and Smad5, plays a critical role in hair follicle stem cell regulation and hair morphogenesis, with distinct roles from pSmad8.
40 citations
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January 2018 in “International journal of trichology” This article reviews the relationship between scalp conditions and hair health, suggesting that shampoos with Malassezia inhibitory agents may help reduce premature hair loss, but it presents no new clinical results.
14 citations
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March 1995 in “Journal of cell science” This study found that targeting SV40 T antigen expression to hair follicles in transgenic mice caused abnormal hair structure and hair loss, but did not lead to cell immortalization or tumor formation in follicles.
January 2009 in “International Journal of Trichology” Dr. Shyam B Verma encourages more scientific research on hair disorders and criticizes the unscientific hair care market in India.
1 citations
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May 2023 in “Research journal of pharmacognosy and phytochemistry” This article discusses the growing preference for organic and herbal cosmetics for hair care, attributing this trend to reduced side effects compared to their synthetic counterparts, and highlights ingredients like fenugreek, flaxseed, and ginger for their potential benefits in preventing hair issues and promoting growth.
March 2026 in “Journal of Health Wellness and Community Research” In this study of young adults in Lahore, Pakistan, researchers reported a 55.2% prevalence of premature graying before age 30, commonly linked with factors like family history, nutritional deficiencies, hair loss, oily scalp, anxiety, and smoking.
October 2025 in “BENTHAM SCIENCE PUBLISHERS eBooks” This chapter explores the potential benefits of using easily available herbal ingredients in hair care formulations, suggesting they offer therapeutic benefits with reduced side effects for various hair issues like dandruff and hair fall, especially in sensitive populations.
November 2025 in “International Journal for Research in Applied Science and Engineering Technology” This study describes the creation of a herbal hair oil using natural ingredients like curry leaves and hibiscus and found that the F1 oil formulation effectively reduces hair fall, removes dandruff, improves scalp blood flow, prevents early graying, and combats fungal infections.
February 2023 in “Journal of Pre-Clinical and Clinical Research” Dhathri Hair Care Plus herbal oil helps reduce hair loss, treat scalp conditions, and slow down hair greying.
January 2025 in “International journal of Indian medicine” This article discussed the potential risks of commercial hair oils, which may contain harmful ingredients, and suggested that additive-free ayurvedic oils could offer a safer alternative for maintaining healthy hair, while urging dermatologists to be informed about different herbal hair oil options.
April 2024 in “Pharmacognosy research” In this study, researchers developed a herbal hair dye using henna and other natural ingredients that achieved a color similar to natural black on blonde hair, though further testing on various hair shades is needed to explore its full benefits.
August 2021 in “International Journal of Research in Dermatology” This study observed that Amarantha hair oil contains β-sitosterol, which is suggested to promote hair growth.
2 citations
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June 2020 in “Journal of Drug Delivery and Therapeutics” This article discusses various hair-related issues, such as dandruff and hair loss, and outlines potential solutions, highlighting the need for personalized treatments and cost-effective approaches based on specific hair problems.