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This study found that common side effects leading to premature removal of the Norplant contraceptive implant included uterine bleeding, amenorrhea, and headaches, suggesting the need for improved pre-insertion counseling and screening.

This narrative review explores how psychological stress may contribute to premature skin aging by affecting dermal collagen and elastin remodeling through neuroendocrine, molecular, and cellular pathways, highlighting potential therapeutic targets to preserve skin structure and function.

This study found that the loss of a functional hr gene in mice leads to premature and abnormal hair follicle regression, disrupting normal hair cycling and architecture.

This study suggests that oxidative stress may contribute to androgenetic alopecia by inducing premature senescence and secretion of hair growth inhibitors in dermal papilla cells from balding scalp.

This report describes a case in which intramuscular cyanocobalamin treatment reversed skin and nail pigmentation changes and premature gray hair caused by vitamin B12 deficiency due to pernicious anemia.

This study found that Notch signaling is crucial for maintaining proper melanocyte distribution and preventing premature differentiation in the melanocyte lineage within hair follicles.

This study found that brain-derived neurotrophic factor (BDNF) inhibited hair shaft elongation and induced premature catagen development in cultured human hair follicles, partially through transforming growth factor β2.

This study identified a new heterozygous mutation in the connexin 26 gene (c.263C>T; p.Ala88Val) in a premature neonate with KID syndrome, who later died from complications.

This study suggests that in women with androgenic alopecia and men with premature balding, enhanced 5α-reductase activity and altered androgen conjugation, favoring sulfurylation, may be involved in scalp hair loss.

This study found that subcutaneous injections of guanethidine or 6-hydroxydopamine induced premature hair growth in mice, suggesting a role for sympathetic nerves in hair growth control.

This case report describes a patient with skin and nail hyperpigmentation and premature gray hair due to vitamin B12 deficiency, which were reversed after treatment with cyanocobalamin.

This study observed that disrupting the Pnkp gene in adult mice resulted in a premature aging-like phenotype, suggesting PNKP's vital role in maintaining normal growth and survival of certain progenitor cell populations.

In this study, an unexpected premature birth of two goat kids occurred following prostaglandin administration in a timed artificial insemination protocol, with both kids exhibiting congenital abnormalities such as laryngotracheal swelling and generalized alopecia.

This study suggests that rosemary oil use may reduce the likelihood of premature hair greying among users in Saudi Arabia, though further research is needed to validate these findings.

This study found that Camellia japonica seed extract promotes hair growth by preventing premature cellular senescence and enhancing the activity of hair follicle stem cells in cases of pattern hair loss.

This study found that teenage girls born via assisted reproductive technologies displayed premature development of secondary sexual characteristics and elevated hormone levels, indicating late precocious puberty and androgen excess.

This study found that miR-22 regulates hair loss in mice by causing premature regression of hair follicles and suggests the importance of the microRNA regulatory network in understanding hair cycling and loss.

In this study, Zingiber coralliaum oil induced premature hair growth in mouse skin during tests, suggesting its potential for managing hair growth disorders.

This article discusses how metabolic imbalances can trigger telogen effluvium by causing hair follicles to prematurely enter the shedding phase, and includes no new research findings.

In this study, researchers found that substance P triggered premature catagen development and immune changes in human scalp hair follicles, providing a possible biological link between stress and hair loss conditions like telogen effluvium and alopecia areata.

This study suggests that ultrasound and color Doppler analyses may enhance the differential diagnosis of GnRH-dependent precocious puberty in girls with premature breast development or pubic hair growth.

This study found that oxidative damage is present in the mitochondria of PolG mice, which exhibit premature aging-like phenotypes due to mitochondrial dysfunction.

This study found that overexpression of parathyroid hormone-related protein in mice resulted in 30–40% shorter hair due to premature transition into the catagen phase of the hair cycle.

This study identified overexpression of certain immune-related genes and underexpression of genes in specific signaling pathways in premature androgenetic alopecia, suggesting potential new therapeutic targets.

This study of African-American women found that those perceiving greater hair breakage showed lower break stress and higher premature failure rates, linked to grooming practices and hair curvature.

In a study using a mouse model, HF-MSCs were reported to enhance ovarian function in cyclophosphamide-induced premature ovarian failure more effectively than HU-MSCs, potentially by preventing ferroptosis in granulosa cells via the KEAP1/NRF2/HO-1 pathway.

In this study, researchers found that deleting the Bmi1 gene in murine melanocytes caused premature hair greying and loss of melanocyte lineage cells, highlighting BMI1's role in protecting melanocyte stem cells from stress and oxidative damage.

This article reviews the potential male equivalent of polycystic ovarian syndrome, focusing on hormonal alterations and premature androgenic alopecia, but reports no new clinical findings; the authors highlight the need for further studies on adrenal steroids and other factors.

In this study, Dguok deficiency in mice led to premature hair greying due to a loss of melanocyte stem cells and mature melanocytes, with increased oxidative stress and cell death; treatment with an antioxidant mitigated these effects, suggesting DGUOK's importance in hair pigmentation maintenance.

In this study on mice, elevated IGF-1 levels in the skin were linked to premature aging of hair follicles, but interventions like reducing IGF-1 or using senolytic treatments helped restore stem cell health and counteract aging effects.