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Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

Finasteride helps reduce heart issues and improves heart function.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Long-term use of dutasteride for enlarged prostate may worsen blood sugar, cholesterol, and erectile dysfunction.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

The study found genetic differences related to hair development that may explain hair loss in a patient with Trichorhinophalangeal syndrome type I.

5α-reductase inhibitors don't stop bladder cancer from developing or getting worse.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

5α-reductase inhibitors help shrink the prostate, improve urinary symptoms, and may reduce prostate cancer risk.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Muscles can make their own androgens, which may help muscle growth.

Testosterone and its metabolites affect brain functions and could help treat neurological disorders.

5-alpha reductase inhibitors may help protect the brain and gut in Parkinson's disease.

Pinus densiflora extract may help improve memory and reduce brain inflammation.

Extracts from Cercidiphyllum japonicum wood can stimulate mouse hair cell growth like common hair growth treatments.