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30 / 567 results![Into the redox control: N-acetyl-cysteine pleiotropic effects from the laboratory to clinical applications](/images/research/84a6169d-1188-4fbb-956f-7434071325c5/small/34916.jpg)
research Into the redox control: N-acetyl-cysteine pleiotropic effects from the laboratory to clinical applications
N-acetyl-cysteine shows promise in treating various diseases and may improve skin and hair conditions, but more research is needed on dosages and long-term effects.
![Wnt Signaling and Aging-Related Heart Disorders](/images/research/f60be97d-4f3b-4096-a9e9-353aa8b2dd41/small/19886.jpg)
research Wnt Signaling and Aging-Related Heart Disorders
Wnt signaling may be linked to heart diseases in aging and could be a target for future treatments.
![The exaptation of endocrine pharmacology](/images/research/a72fcbe9-f73a-4f7e-86bf-962cb5a21b4c/small/26093.jpg)
research The exaptation of endocrine pharmacology
Old drugs are often used for new, different medical purposes in endocrine pharmacology.
![Hair growth effects of Laminaria japonica extract and growth factor mixture on a C57BL/6 mouse model](/images/research/25055c2b-3402-4a7b-ad99-41e71f66e012/small/21711.jpg)
research Hair growth effects of Laminaria japonica extract and growth factor mixture on a C57BL/6 mouse model
Laminaria japonica extract with IGF-1 improved mouse hair growth and could be a potential alopecia treatment.
![Thehairless gene of the mouse: Relationship of phenotypic effects with expression profile and genotype](/images/research/e36101d0-9c14-4466-8605-d02429f1e1f3/small/20047.jpg)
research Thehairless gene of the mouse: Relationship of phenotypic effects with expression profile and genotype
Mutations in the hairless gene in mice affect its expression and lead to a range of developmental issues in multiple tissues.
![Analysis of hidradenitis suppurativa–linked mutations in four genes and the effects of PSEN1-P242LfsX11 on cytokine and chemokine expression in macrophages](/images/research/a231752d-70b9-49d9-92ea-e1140e88166f/small/19384.jpg)
research Analysis of hidradenitis suppurativa–linked mutations in four genes and the effects of PSEN1-P242LfsX11 on cytokine and chemokine expression in macrophages
The document concludes that certain mutations may contribute to the inflammation in hidradenitis suppurativa and suggests that targeting TNFα could be a treatment strategy.
![Androgens’ Effects across the Lifespan in Men and Animal Models](/images/research/f0a9376b-c94c-4cc1-8335-72b4c3ef0dc0/small/12058.jpg)
research Androgens’ Effects across the Lifespan in Men and Animal Models
Androgens, male hormones, affect physical and mental functions, with a decrease leading to health issues like muscle loss, bone disease, and depression, and more research is needed on long-term effects and treatments.
![New effects of caffeine on corticotropin‐releasing hormone (CRH)‐induced stress along the intrafollicular classical hypothalamic–pituitary–adrenal (HPA) axis (CRH‐R1/2, IP<sub>3</sub>‐R, ACTH, MC‐R2) and the neurogenic non‐HPA axis (substance P, p75<sup>NTR</sup>and TrkA) in<i>ex vivo</i>human male androgenetic scalp hair follicles](/images/research/bd3b4fff-2da8-40d0-b183-984a889c2452/small/17452.jpg)
research New effects of caffeine on corticotropin‐releasing hormone (CRH)‐induced stress along the intrafollicular classical hypothalamic–pituitary–adrenal (HPA) axis (CRH‐R1/2, IP3‐R, ACTH, MC‐R2) and the neurogenic non‐HPA axis (substance P, p75NTRand TrkA) inex vivohuman male androgenetic scalp hair follicles
Caffeine may help reduce stress-induced hair loss.
research Impaired metabolic effects of metformin in men with early-onset androgenic alopecia
![The Effects of Negative Pressure Therapy on Hair Growth of Mouse Models](/images/research/7013e48c-dad1-4c3c-b247-d64d58740158/small/30236.jpg)
research The Effects of Negative Pressure Therapy on Hair Growth of Mouse Models
Negative pressure therapy increases hair growth in mice.
![Effects of lifelong testosterone exposure on health and disease using Mendelian randomization](/images/research/c0e8dbb9-72db-42ac-b67f-6d3337779e2b/small/13342.jpg)
research Effects of lifelong testosterone exposure on health and disease using Mendelian randomization
Higher testosterone levels can increase the risk of certain diseases like type 2 diabetes in women and prostate cancer in men, but can also protect against autoimmune diseases and hair loss. It also affects body fat and bone density.
![Author response: Effects of lifelong testosterone exposure on health and disease using Mendelian randomization](/images/research/5b5decd2-f703-4f03-ac11-d2259375729c/small/26430.jpg)
research Author response: Effects of lifelong testosterone exposure on health and disease using Mendelian randomization
Long-term high testosterone levels can improve bone density and reduce body fat but may increase the risk of prostate cancer and high blood pressure.
![Decision letter: Effects of lifelong testosterone exposure on health and disease using Mendelian randomization](/images/research/7ee8d36d-7e95-4f42-931d-86222f40edc9/small/20851.jpg)
research Decision letter: Effects of lifelong testosterone exposure on health and disease using Mendelian randomization
Increased free testosterone can lead to stronger bones and less body fat but also higher risks of prostate cancer, hair loss, spine issues, and high blood pressure.
![A powerful method for pleiotropic analysis under composite null hypothesis identifies novel shared loci between Type 2 Diabetes and Prostate Cancer](/images/research/22b8029d-284a-43b5-aafe-bd41f6a7e768/small/17345.jpg)
research A powerful method for pleiotropic analysis under composite null hypothesis identifies novel shared loci between Type 2 Diabetes and Prostate Cancer
New method finds genetic links between Type 2 Diabetes and Prostate Cancer not seen before.
research A conditional multi-trait sequence GWAS discovers pleiotropic candidate genes and variants for sheep wool, skin wrinkle and breech cover traits
Researchers found genes and genetic variants linked to sheep wool and skin wrinkles.
![Advances in Knowledge of Androgens: How Intentional and Accidental Neurosteroid Changes Inform Us of Their Action and Role](/images/research/fd924381-55ca-4331-86a9-0f0ec577142c/small/12126.jpg)
research Advances in Knowledge of Androgens: How Intentional and Accidental Neurosteroid Changes Inform Us of Their Action and Role
Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.
![Non-Rash Skin Toxicities Associated with Novel Targeted Therapies](/images/research/7faa66ac-91a1-4c16-98b2-7a0b01b1456c/small/34089.jpg)
research Non-Rash Skin Toxicities Associated with Novel Targeted Therapies
Early recognition and management of skin side effects from new cancer therapies can prevent treatment delays.
![The Role of Topical Vitamin D in Vitiligo: A Narrative Literature Review](/images/research/31dc3904-5800-4ac6-8061-75f2a8ebd072/small/27883.jpg)
research The Role of Topical Vitamin D in Vitiligo: A Narrative Literature Review
Topical vitamin D is effective in treating vitiligo with few side effects.
![Tofacitinib citrate alleviates alopecia universalis symptoms in recent case study](/images/research/8b88b852-ab3f-42ba-8c63-466df1e16c43/small/26405.jpg)
research Tofacitinib citrate alleviates alopecia universalis symptoms in recent case study
Tofacitinib helped a person with total body hair loss grow hair again without bad side effects.
![Pharmacological Options for Treatment of Hyperandrogenic Disorders](/images/research/6ee398cf-8a38-485b-b59b-90617af0ac1c/small/15007.jpg)
research Pharmacological Options for Treatment of Hyperandrogenic Disorders
Different drugs can treat high male hormone levels in women, but they have various effects and some may harm a fetus.
![The Rotterdam Study: 2018 update on objectives, design and main results](/images/research/6b2bf1e2-b450-45e9-acf3-ca3b9fb4830a/small/16032.jpg)
research The Rotterdam Study: 2018 update on objectives, design and main results
The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.
![The Rotterdam Study: 2016 objectives and design update](/images/research/c244fc74-a75b-4325-bf8e-e8b46008026d/small/16165.jpg)
research The Rotterdam Study: 2016 objectives and design update
The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.
![Ectopic Expression of the nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia](/images/research/04203292-2faa-4d4c-bab0-89a81e85df9d/small/29662.jpg)
research Ectopic Expression of the nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia
The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.
![Insights learned from L457(3.43)R, an activating mutant of the human lutropin receptor](/images/research/26339203-be2b-405f-9add-a9350032340a/small/15116.jpg)
research Insights learned from L457(3.43)R, an activating mutant of the human lutropin receptor
The L457(3.43)R mutation in the human lutropin receptor causes increased activity and hormone insensitivity, leading to precocious puberty.
![Cardiometabolic Risk Factors in Rosuvastatin-Treated Men with Mixed Dyslipidemia and Early-Onset Androgenic Alopecia](/images/research/9eab96f8-0acb-4da1-acb4-8994c8e32996/small/5222.jpg)
research Cardiometabolic Risk Factors in Rosuvastatin-Treated Men with Mixed Dyslipidemia and Early-Onset Androgenic Alopecia
Rosuvastatin improves lipid levels, reduces inflammation, but worsens insulin sensitivity in men with early-onset hair loss.
![Metformin Promotes Mechanical Stretch-Induced Skin Regeneration by Improving the Proliferative Activity of Skin-Derived Stem Cells](/images/research/ef3bb376-600d-4668-b184-6d05b4d85a04/small/30145.jpg)
research Metformin Promotes Mechanical Stretch-Induced Skin Regeneration by Improving the Proliferative Activity of Skin-Derived Stem Cells
Metformin helps improve skin regeneration by increasing the growth of skin stem cells.
![Exogenous stimulation with Eclipta alba promotes hair matrix keratinocyte proliferation and downregulates TGF-β1 expression in nude mice](/images/research/2a8813c7-ca9b-413e-90d0-c8e594768af0/small/23089.jpg)
research Exogenous stimulation with Eclipta alba promotes hair matrix keratinocyte proliferation and downregulates TGF-β1 expression in nude mice
Eclipta alba extract helps increase hair growth and decrease hair loss-related protein in mice.
![<i>In vivo</i>hair growth-stimulating effect of medicinal plant extract on BALB/c nude mice](/images/research/81455455-61e6-4a4f-99fa-c7f7ecd94384/small/14229.jpg)
research In vivohair growth-stimulating effect of medicinal plant extract on BALB/c nude mice
Chrysanthemum zawadskii extract may be a better treatment for hair loss than Minoxidil.
![Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression (Catagen) by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla](/images/research/04a93fba-b549-4c4b-95c2-595bcd9715d0/small/23248.jpg)
research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression (Catagen) by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla
All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.