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    Did you mean Plasminogen Activator Inhibitor-1?
    Glossary Plasminogen Activator Inhibitor-1

    regulates blood clot breakdown by inhibiting plasminogen conversion enzymes

    Plasminogen Activator Inhibitor-1 (PAI-1) is a protein that regulates the breakdown of blood clots by inhibiting enzymes that convert plasminogen to plasmin, which is responsible for clot degradation. Elevated levels of PAI-1 are associated with an increased risk of thrombosis and various cardiovascular diseases, as it can lead to excessive clot formation.

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    Research 30 of 354

    1. Localization of Plasminogen Activator Inhibitor Type 2 (PAI-2) in Hair and Nail: Implications for Terminal Differentiation 1998 · 42 citations
    2. Role of plasminogen activator inhibitor type 1 (PAI-1) in PCOS patient International journal of reproduction, contraception, obstetrics and gynecology · 2017 · 3 citations
    3. Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women BMC women's health · 2023 · 2 citations
    4. Thrombin activatable fibrinolysis inhibitor and other hemostatic parameters in patients with polycystic ovary syndrome Gynecological Endocrinology · 2009 · 29 citations
    5. Urokinase plasminogen activator (uPA) is a positive regulator of outer root sheath keratinocyte proliferation Cell Biology International · 2004 · 2 citations
    6. Transient Ca2+ entry by plasmalogen-mediated activation of receptor potential cation channel promotes AMPK activity Frontiers in molecular biosciences · 2022 · 3 citations
    7. Proteomics Characterization of Primary Human Oral Epithelial Cells Using a Novel Culture Technique for Use in Tissue Regeneration MOJ proteomics & bioinformatics · 2015
    8. Wound healing in development Birth Defects Research · 2012 · 29 citations
    9. The role of integrin alphavbeta6 in impaired wound healing and hair follicle regeneration 2010
    10. Urokinase is a Positive Regulator of Epidermal Proliferation In Vivo Journal of Investigative Dermatology · 1999 · 28 citations
    11. Ku80 as a Novel Receptor for Thymosin β4 That Mediates Its Intracellular Activity Different from G-actin Sequestering Journal of Biological Chemistry · 2007 · 37 citations
    12. Matriptase: Potent Proteolysis on the Cell Surface Molecular Medicine · 2006 · 165 citations
    13. Defining stem cell dynamics and migration during wound healing in mouse skin epidermis Nature Communications · 2017 · 363 citations
    14. Enzyme Inhibitors from Gorgonians and Soft Corals Marine Drugs · 2023 · 4 citations
    15. Forsythiaside A protects against focal cerebral ischemic injury by mediating the activation of the Nrf2 and endoplasmic reticulum stress pathways Molecular Medicine Reports · 2019 · 12 citations
    16. The PDGF/PDGFR pathway as a drug target Molecular Aspects of Medicine · 2017 · 182 citations
    17. Follikelhormone Springer Reference Medizin · 2019
    18. LH Induces Murine Hair Loss through TRPC-Medicated Cell Aging Responses: Implications for Female Pattern Hair Loss Pathogenesis Journal of Investigative Dermatology · 2025
    19. The hair growth promoting effect of extract and its molecular regulation Journal of Dermatological Science · 2005 · 87 citations
    20. Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier European Journal of Medicinal Chemistry · 2024 · 4 citations
    21. Matriptase Expression and Zymogen Activation in Human Pilosebaceous Unit 2013 · 9 citations
    22. Targeting host cell proteases as a potential treatment strategy to limit the spread of SARS‐CoV‐2 in the respiratory tract Pharmacology Research & Perspectives · 2020 · 15 citations
    23. JMJD3 and NF-κB-dependent activation of Notch1 gene is required for keratinocyte migration during skin wound healing Scientific Reports · 2017 · 54 citations
    24. Elevated Circulation Levels of an Antiangiogenic SERPIN in Patients with Diabetic Microvascular Complications Impair Wound Healing through Suppression of Wnt Signaling Journal of Investigative Dermatology · 2014 · 74 citations
    25. TGF-β Signaling: a Potential Therapeutic Target of Single Herbs and Extracts for Renal Fibrosis 2022
    26. Pharmacologic Treatment of Polycystic Ovary Syndrome Seminars in reproductive medicine · 2003 · 21 citations
    27. Metabolic Aspects of Polycystic Ovary Syndrome Postgraduate obstetrics & gynecology · 2015
    28. Metabolic risk in PCOS: phenotype and adiposity impact Trends in Endocrinology and Metabolism · 2015 · 162 citations
    29. Polycystic Ovary Syndrome (PCOS) and Other Androgen Excess–Related Conditions: Can Changes in Dietary Intake Make a Difference? Nutrition in Clinical Practice · 2008 · 48 citations
    30. Polycystic Ovary Syndrome: A Comprehensive Review of Its Clinical Presentation, Comorbidities, Long-Term Complications and Management International Journal of Pharmaceutical Research and Applications · 2025