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    Glossary Plakophilin-1

    protein crucial for cell adhesion in skin and hair

    Plakophilin-1 (PKP1) is a protein that plays a crucial role in the formation and maintenance of desmosomes, which are structures that help cells stick together, particularly in tissues that experience a lot of stress, like the skin and heart. Mutations in the gene encoding Plakophilin-1 can lead to skin disorders and hair loss conditions, such as ectodermal dysplasia/skin fragility syndrome, highlighting its importance in maintaining the integrity of epithelial tissues.

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    Research 30 of 83

    1. Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis 2012 · 47 citations
    2. Deficient Plakophilin-1 Expression Due to a Mutation in PKP1 Causes Ectodermal Dysplasia-Skin Fragility Syndrome in Chesapeake Bay Retriever Dogs PLoS ONE · 2012 · 28 citations
    3. Plakophilin 1 suppresses keratinocyte innate immune responses through DExD/H helicases 2026
    4. Immunolocalization of junctional proteins in human hairs indicates that the membrane complex stabilizes the inner root sheath while desmosomes contact the companion layer through specific keratins Acta Histochemica · 2013 · 12 citations
    5. Animal models of human skin disease Experimental Dermatology · 2004 · 4 citations
    6. Intercellular junctions in normal epidermis Experimental Dermatology · 2004 · 2 citations
    7. Decision letter: Complementary evolution of coding and noncoding sequence underlies mammalian hairlessness 2022
    8. Histopathological and Ultrastructural Study of Ectodermal Dysplasia/Skin Fragility Syndrome The American Journal of Dermatopathology · 2005 · 31 citations
    9. Alopecia in Epidermolysis Bullosa Dermatologic Clinics · 2009 · 21 citations
    10. Hair Loss in Autoimmune Cutaneous Bullous Disorders Dermatologic Clinics · 2011 · 12 citations
    11. Dermatopathology and molecular genetics Journal of The American Academy of Dermatology · 2008 · 12 citations
    12. Inherited Disorders of the Hair Elsevier eBooks · 2013 · 2 citations
    13. Towards a molecular understanding of hair loss and its treatment Trends in Molecular Medicine · 2001 · 236 citations
    14. Biology and Genetics of Hair Annual Review of Genomics and Human Genetics · 2010 · 89 citations
    15. Beyond Expectations International review of cell and molecular biology · 2014 · 70 citations
    16. Mechanical forces in skin disorders Journal of Dermatological Science · 2018 · 65 citations
    17. Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: An update Journal of Dermatological Science · 2012 · 52 citations
    18. To grow or not to grow: Hair morphogenesis and human genetic hair disorders Seminars in Cell & Developmental Biology · 2013 · 43 citations
    19. Congenital hair loss disorders: Rare, but not too rare The Journal of Dermatology · 2011 · 41 citations
    20. The Genetics of Human Skin Disease Cold Spring Harbor Perspectives in Medicine · 2014 · 24 citations
    21. Unraveling the Molecular Mechanisms of Hair and Nail Genodermatoses Archives of Dermatology · 2001 · 23 citations
    22. Skin transcriptome profiling of Changthangi goats highlights the relevance of genes involved in Pashmina production Scientific reports · 2020 · 22 citations
    23. Differential proteomics of lesional vs. non-lesional biopsies revealed non-immune mechanisms of alopecia areata Scientific Reports · 2018 · 19 citations
    24. Molecular Genetics of Alopecias Current problems in dermatology · 2015 · 9 citations
    25. 1310 Anti-aging effects of retinoid hydroxypinacolone retinoate on skin models Journal of Investigative Dermatology · 2018 · 4 citations
    26. Computational derivation of a molecular framework for hair follicle biology from disease genes Scientific Reports · 2017 · 4 citations
    27. Complementary evolution of coding and noncoding sequence underlies mammalian hairlessness bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 2 citations
    28. 1313 Fzd2 controls multiple aspects of epidermal development through distinct signaling mechanisms Journal of Investigative Dermatology · 2018 · 1 citations
    29. Structure and Function of the Skin Elsevier eBooks · 2012 · 1 citations
    30. DNA Methylation‐Regulated ZDHHC17 Promotes the Risk of Facial Skin Aging Clinical Cosmetic and Investigational Dermatology · 2025