April 2025 in “Biomacromolecules” This study developed microneedles loaded with Platycladus orientalis leaf extract to treat androgenic alopecia, finding that they can effectively deliver active ingredients into the dermis, promote hair follicle growth by removing free radicals, and activate the Wnt/β-catenin pathway.
November 2025 in “Quantum Wellness : Jurnal Ilmu Kesehatan” This study analyzed the ethanol extract of pacing tawar leaves and found it contains alkaloids, saponins, tannins, and steroids but not flavonoids, suggesting potential for use in natural medicinal products.
August 2025 in “Journal of Medical and Biological Engineering” In this study, a needle-free supersonic atomizer delivering Bacopa monnieri extract with hyaluronan was found to enhance hair growth in mice more effectively than the traditional smear method and minoxidil.
April 2019 in “International research journal of pharmacy” This study found that a 50% ethanolic extract of Adiantum capillus had significant analgesic and anti-inflammatory effects in animals, particularly at the highest tested dose of 300 mg/kg.
111 citations
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April 2023 in “Ultrasonics Sonochemistry” This review discusses the extraction, purification, and biological activities of maidenhairtree polysaccharides, emphasizing the higher efficiency of ultrasound-assisted extraction, but it reports no new clinical results.
16 citations
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October 2018 in “BMC Complementary and Alternative Medicine” In this animal study, the methanolic extract of Crataeva nurvala leaves was found to possess sedative and anxiolytic properties, potentially linked to GABAergic activity and certain neuroactive compounds.
16 citations
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June 2019 in “Industrial Biotechnology” In this study, researchers found that the conventional solvent extraction method yielded the highest polyphenol content and antioxidant activity from Ascophyllum nodosum seaweed on Québec's North Shore.
1 citations
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January 2014 This study found that Crataegus pinnatifida extract promoted hair growth in mice by inducing the anagen phase, potentially through activating signaling pathways that enhance cell survival.
4 citations
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March 2021 in “Asian Journal of Beauty and Cosmetology” This study found that Dendropanax, sea salt, spinach, and kelp were safe and potentially effective as ingredients in functional cosmetics aimed at alleviating hair loss symptoms.
1 citations
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January 2017 in “Pharmaceutica Analytica Acta” This study found petroleum ether to be more effective than methanol at extracting β-sitosterol from Eclipta alba, with higher concentrations detected using HPTLC and HPLC methods. The extracted materials contained metals within safety limits.
April 2025 in “The Journal of Agriculture and Development” In this study, researchers optimized the extraction conditions for polyphenols from the medicinal herb Eclipta prostrata, achieving the highest polyphenol content under specific conditions of temperature, solvent concentration, and time, and found the extract to have significant antioxidant activity.
November 2024 in “TẠP CHÍ KHOA HỌC TRƯỜNG ĐẠI HỌC QUỐC TẾ HỒNG BÀNG” This study investigated the botanical characteristics and preliminary phytochemical components of Nepenthes kampotiana, revealing its morphological structure, including pitcher-like leaves for trapping prey, and identifying chemical groups such as essential oils, triterpenoids, flavonoids, and tannins.
4 citations
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September 2015 in “Bulletin of the Korean Chemical Society” This study presents a new method using UPLC-ESI-MS/MS for analyzing the constituents of a medicinal herbal complex extract, which includes herbs traditionally used to prevent hair loss and promote hair growth; no clinical results were reported.
118 citations
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July 2005 in “Journal of Ethnopharmacology” In this study, the aqueous extract of Eclipta alba and its hydrolyzed fraction showed nootropic activity and reduced stress-induced alterations in rats.
2 citations
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April 2016 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that a novel saw palmetto supercritical CO2 extract effectively inhibits 5α-reductase type II in vitro, suggesting its potential for promoting prostate health in benign prostatic hyperplasia.
2 citations
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January 2021 in “Applied Chemistry for Engineering” This review discusses the bioactive substances found in native Korean Pinus densiflora and koraiensis and highlights the need for more research on their industrial application, despite known physiological effects.
February 2023 in “Medicine in novel technology and devices” This study found that microneedle delivery of Polygonum multiflorum extract led to earlier pigmentation and hair regrowth in mice with androgenetic alopecia.
3 citations
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April 2016 in “Research and reports in urology” In a cell-free test setting, this study found that a novel saw palmetto extract effectively inhibited the 5α-reductase type II enzyme, showing promising bioactivity comparable to finasteride for promoting prostate health.
May 2024 in “NATIONS UNIVERSITY INTERNATIONAL JOURNAL OF MULTI-DISCIPLINARY STUDIES” This study found that Equisetum arvense, or horsetail, water extracts prepared with polyethylene glycol in an ultrasonic bath yielded the highest levels of phenolic compounds, such as hydroxycinnamic acids and flavonoids, indicating that this method improves the release of biologically active substances.
4 citations
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December 2020 in “Natural Product Sciences” This study identified ten compounds from Eclipta prostrata, with some displaying potent inhibitory effects against α-glucosidase and acetylcholinesterase enzymes.
June 2025 in “Formosa Journal of Sustainable Research” In this study, the NADES extract of mangkokan leaves (Polyscias scutellaria) demonstrated antibacterial activity against Escherichia coli and Staphylococcus aureus, with a total flavonoid content measured at 4.944 mgEQ/gSimplisia using the disc diffusion method.
46 citations
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July 2010 in “Advances in Therapy” SPET-085 effectively inhibits an enzyme linked to prostate issues, similar to finasteride.
3 citations
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October 2024 in “Frontiers in Pharmacology” This laboratory study found that PI extract, along with its metabolites Ang and Mac, inhibited cell proliferation and protein expression linked to pathways involved in BPH, suggesting potential for therapeutic use, although the Ang-Mac combination showed no significant effect on apoptosis through the p53 pathway.
April 2021 in “Journal of Investigative Dermatology” This study suggests that edelweiss extract may promote hair growth and reduce shedding in ex vivo experiments by affecting hair follicle anagen phase duration and keratinocyte proliferation.
3 citations
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October 2018 in “Revista de Chimie” This review discusses the potential medicinal properties and pharmacokinetic features of nettle compounds ursolic acid and quercetin, highlighting quercetin as a promising candidate for antioxidant and anti-aging effects, but reports no new clinical results.
1 citations
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January 2022 in “Journal of Oleo Science” This study found that an aqueous extract of Phyllanthus emblica, primarily containing gallic acid, can activate hair growth gene expression and is effectively delivered to hair follicles using transfersomes.
In this study, perilla seed extract obtained through supercritical fluid extraction was found to promote hair follicle cell proliferation and downregulate key genes linked to androgenetic alopecia, showing potential as a natural treatment for hair loss in vitro.
This study explored chitosan-based dissolving microneedle arrays loaded with Agave tequilana root extract, finding that extract concentration influenced microneedle geometry and bioactivity, maintaining antioxidant and enzyme inhibitory effects while reducing collagenase inhibition, particularly in the 0.25% formulation.
March 2025 in “IUScholarWorks (Indiana University)” In this study, two female patients with low libido experienced increased testosterone levels and improved energy after using Testim transdermal gel for six weeks, though only one reported increased libido, indicating potential benefits of testosterone therapy in women despite its limited use.
22 citations
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February 2018 in “International Journal of Pharmacy and Pharmaceutical Sciences” This review compiles existing research on Peperomia pellucida's traditional medicinal uses and pharmacological properties but reports no new findings, suggesting its potential for drug development.