June 2021 in “Zenodo (CERN European Organization for Nuclear Research)” This study evaluated the stability and capillary growth-stimulating activity of emulsions made with natural plant extracts and oils in vivo on guinea pigs, finding that specific hydrophilic/lipophilic balance and globule size contribute to a stable and effective formulation.
June 2021 in “World Journal Of Advanced Research and Reviews” In this study, researchers evaluated emulsions made with natural plant extracts and oils on guinea pigs, finding that a specific hydrophilic/lipophilic balance and globule size led to a stable emulsion and stimulated hair growth.
January 2015 in “Zhongguo haiyang yaowu” This study found that collagen oligopeptides from puffer skin may reduce skin melanin and increase hydroxyproline content in guinea pigs, suggesting potential skin whitening and anti-aging effects.
January 2008 in “Chinese Journal of Aesthetic and Plastic Surgery” This study found that an injectable material derived from hair shows good biocompatibility and promotes dermal thickness in pigs, suggesting potential as a new soft tissue filling agent.
January 1985 in “Clinical research” This study found that topical alpha-terthienyl combined with UVA radiation rapidly induced dose-dependent cutaneous photosensitization in guinea pigs, suggesting potential for photochemotherapy in skin disorders without future carcinogenic risks.
September 1980 in “PubMed” This study found that applying a surfactant solution with 2.5% selenium disulfide to the back of guinea pigs significantly increased telogen hair, which may relate to observations of diffuse hair loss in humans under intense exposure conditions.
February 2023 in “Pharmaceutics” This study found that oral administration of 7, 8–dihydroxyflavone in guinea pigs improved recovery from gentamicin-induced vestibular damage, suggesting potential therapeutic use for vestibular dysfunction in humans.
65 citations
,
April 2000 in “The Laryngoscope” This study concluded that clotrimazole, miconazole, and tolnaftate appeared safe in guinea pigs, whereas gentian violet showed potential for severe ototoxicity, and nystatin left a concerning residue.
15 citations
,
January 2003 in “Lasers in Surgery and Medicine” This study found that cold air can effectively preserve the epidermis when using an 810 nm diode laser, but it is slightly less effective than a chilled sapphire window in dark-haired pigmented pigs.
14 citations
,
January 2014 in “Tropical Journal of Pharmaceutical Research” In this study, a hydroalcoholic extract of Urtica dioica L. showed potential for use as an adjunct topical treatment for tinea corporis in guinea pigs infected with Microsporum canis.
2 citations
,
March 2015 in “Toxicology and Environmental Health Sciences” This study found that rice bran supercritical CO₂ extract was classified as a non-irritant for ocular use but a moderate irritant for dermal use in rabbits and guinea pigs.
This research observed that hairless guinea pig dermal fibroblasts were more sensitive to a toxic exposure than human dermal fibroblasts, suggesting that guinea pigs might serve as an intermediate model for translating in vitro findings to whole organisms.
December 2021 in “Ad-Dawaa' Journal of Pharmaceutical Sciences” This study concluded that hair tonic formulations using extracts of green tea leaves, celery leaves, or their combination can effectively promote hair growth in guinea pigs, with the fastest growth seen using a 2.5% green tea to 7.5% celery leaf extract ratio.
In this experimental study, hibiscus leaf extract at a 30% concentration showed effectiveness in promoting hair growth on guinea pigs, with measurable increases in hair length and weight by the 21st day.
This study found that the hydroalcoholic extract of Urtica dioica L. demonstrated some clinical efficacy in reducing lesion severity in guinea pigs with Microsporum canis infections, suggesting potential as a supplementary topical treatment for tinea corporis.
5 citations
,
April 1946 in “PubMed” This study found that a diet with purified casein and sulfasuxidine resulted in poor growth and anemia in a pig, which improved after treatment with a liver extract.
2 citations
,
January 1974 in “Archives of Dermatological Research” Unknown factors significantly affect hair growth in skin grafts.
1 citations
,
September 2024 in “Veterinary Medicine and Science” In this study, researchers found that a single oral dose of afoxolaner was safe and effective in treating a severe case of Trixacarus caviae mange in a guinea pig, achieving full remission of clinical signs and mite eradication within 4 weeks without needing repeated treatment.
28 citations
,
January 2000 in “Medical Mycology” This article reviews the impact of natural fungal pathogens on laboratory animal research and reports no new results, calling attention to infection risks with dermatophytes, Candida, and pneumonia in immunocompromised rodents.
14 citations
,
March 2020 in “Scientific Reports” This study found that dual-frequency ultrasound with microbubble cavitation significantly enhanced minoxidil delivery and hair growth in both lab and animal models compared to single-frequency ultrasound, without damaging the skin in mice.
2 citations
,
May 1981 in “Journal of Animal Science” The researchers concluded that while swine hair mineral content is influenced by dietary levels, the variability and interaction between minerals suggest it may not be a reliable indicator of an animal's overall mineral composition.
This study suggests that estrogen in contraceptive therapy may affect hair growth, potentially correcting hair loss under certain hormonal conditions; however, applying these findings to humans should be done cautiously.
149 citations
,
September 2017 in “Pharmaceutics” This review compares animal and human skin characteristics in in vitro permeation studies but reports no new results, highlighting variations and the need for better model correlations.
49 citations
,
January 1991 in “Food and chemical toxicology” In this study, zinc chloride was found to be severely irritant to the skin in rabbit, guinea-pig, and mouse models, while zinc oxide, zinc sulphate, zinc pyrithione, and zinc undecylenate showed minimal to no irritancy.
33 citations
,
January 1996 in “CRC Press eBooks” This article reviews various models used in dermatopharmacology research, exploring their applications in studying skin conditions and hair growth, but reports no new findings.
11 citations
,
January 1992 in “PubMed” In this study, the researchers found distinct patterns of TGF-beta 1 and IGF-II expression in pig fetal subcutaneous tissue, suggesting specific regulatory roles in developing adipocytes and muscle tissue.
4 citations
,
April 2022 in “Microorganisms” In this study, clinically used preoperative skin preparations with povidone iodine and chlorhexidine gluconate did not meet FDA log-reduction standards for bacterial bioburden in a porcine model, suggesting persistent infection risks.
2 citations
,
January 2016 in “Skin pharmacology and physiology” This study found that seed oil of Caragana korshinskii demonstrated high antifungal efficacy against Trichophyton mentagrophytes in an in vivo guinea pig model of dermatophytosis.
November 2010 in “PubMed” Human hair keratin can help repair fat tissue.
60 citations
,
August 1969 in “British Journal of Dermatology” This study used an autoradiographic technique to observe that germicides in surfactants are primarily deposited on the stratum corneum of guinea-pig and human skin.