This study found that scalp micropigmentation significantly improved psychological well-being among adults by enhancing appearance satisfaction and perceived physical attractiveness, but not through a direct relationship with psychological well-being itself.
April 2026 in “The FASEB Journal” In this study, researchers identified exosomal miR-199a-3p as a key factor in the regulation of melanogenesis by dermal papilla cells, finding that it enhances melanocyte proliferation and melanin production, suggesting potential therapeutic targets for pigmentation disorders.
December 2025 in “International Journal of Research in Dermatology” This clinical study in healthy Indian adults found that a four-month application of an Ayurvedic leave-on treatment significantly increased natural black hair density, reduced grey hair count, and was well-tolerated without adverse effects, suggesting its efficacy and safety for treating premature hair greying.
April 2025 in “Turkish Journal of Hematology” Nilotinib may cause gray hair to return to its original color.
September 2024 in “Digital Commons - University of South Florida (University of South Florida)” This study found that injecting various hormones or hormone-cholesterol mixtures into Willow Ptarmigan and White-tailed Ptarmigan led to the growth of pigmented feathers instead of the usual white winter feathers, suggesting hormonal influence on plumage color changes.
September 2024 in “Journal of Investigative Dermatology” VIP reduces hair pigmentation by decreasing melanin production.
July 2024 in “Journal of Investigative Dermatology” Topical sulforaphane reduces pigmentation and wrinkles from sun damage.
February 2005 in “CRC Press eBooks” This article reviews the role of melanins in determining human hair color and discusses the specialized regulation of hair melanocytes during growth, with no new findings reported.
April 1986 in “CRC Press eBooks” This article explains the role of melanins in hair color, focusing on their production by melanocytes, but presents no new research findings.
70 citations
,
December 2004 in “Proceedings of the National Academy of Sciences” This study found that BMP signaling influences hair pigmentation in mice by affecting the Agouti protein and interacts with MC-1R pathways to modulate melanin production.
56 citations
,
November 2010 in “Pigment Cell & Melanoma Research” This article discusses the role of neurohormones and neuropeptides in hair follicle pigmentation and outlines promising neuroendocrinological strategies to address greying and damage, but reports no new clinical results.
20 citations
,
October 2018 in “American Journal of Clinical Dermatology” This article reviews drug-induced pigmentation and reports no new clinical findings, highlighting difficulty in confirming drug associations due to factors like delayed onset and polypharmacy.
17 citations
,
October 2010 in “Pigment cell & melanoma research” This article reviews the impact of H2O2-redox homeostasis on hair follicle pigmentation via tyrosinase and associated mechanisms, discussing primarily findings from murine models without providing new clinical results for humans.
11 citations
,
September 2024 in “Journal of the European Academy of Dermatology and Venereology” This review explores the shared pathogenesis of alopecia areata and vitiligo and compares treatment responses, noting that hair regrowth in alopecia areata occurs more rapidly than skin re-pigmentation in vitiligo, possibly due to differences in stem cell biology and treatment effects on melanocytes.
3 citations
,
January 2021 in “Skin appendage disorders” This study concluded that hair pigmentation, as measured by eumelanin-to-pheomelanin ratio, is not a risk factor for developing alopecia areata when compared to androgenetic alopecia patients.
1 citations
,
June 2025 in “Pigment Cell & Melanoma Research” This literature review reports that mutations in the SASH1 gene are linked to different pigmentation disorders, including dyschromatosis universalis hereditaria and lentiginosis. It further suggests SASH1's significant role in melanocyte processes and its potential as a target for developing treatments for these conditions.
1 citations
,
January 2014 in “International Journal of Trichology” This case report describes a 35-year-old woman with diffuse partial woolly hair occurring alongside epidermolysis bullosa with mottled pigmentation.
February 2026 in “HCA Healthcare Journal of Medicine” This review discusses identifying keratosis pilaris, its common mimics, and its associated skin diseases across different skin tones but reports no new results.
140 citations
,
August 2010 in “Pigment Cell & Melanoma Research” This article discusses mouse genetic studies to explore factors influencing melanogenesis, highlighting pH and cysteine's roles, and proposes a hypothesis for human hair color diversity; it reports no new results.
17 citations
,
February 2011 in “International Journal of Cosmetic Science” This study found that individual differences between pigmented and unpigmented hair fibers in Old Order Mennonites suggest grey hair may be perceived as drier and less manageable due to small mechanical and moisture changes.
6 citations
,
September 2010 in “Pigment Cell & Melanoma Research” This article discusses the roles of different proteins in melanogenesis and proposes a hypothesis to explain the diversity of human hair pigmentation, but it reports no new experimental results.
1 citations
,
April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that inhibiting mTORC1 activity with rapamycin increased both hair growth and pigmentation in human scalp hair follicles, suggesting a potential strategy for treating greying and hair loss.
March 2021 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study found that human dWAT regulates hair growth and pigmentation through HGF secretion, highlighting potential novel targets for treating hair growth and pigmentation disorders.
April 2017 in “Journal of Dermatological Science” In this study, researchers found that in adult mice, new hair follicles with pigmentation can regenerate from the epidermis after skin wounding, aided by melanocyte stem cells moving from nearby existing hair follicles.
March 2013 in “Pigment Cell & Melanoma Research” This study revealed that different coat patterns in cats and cheetahs are related to variations in the aminopeptidase Q gene and endothelin-3 expression, which affects pigment production.
January 2019 in “Clinical pediatric dermatology” This review discusses the use of follicular unit extraction and scalp micropigmentation in treating male pattern baldness, noting that scalp micropigmentation provides a non-surgical option to emulate natural hair appearance without downtime.
26 citations
,
September 1969 in “The American journal of medicine” This article reviews Cronkhite-Canada syndrome as a distinct condition from Peutz-Jeghers syndrome and familial polyposis, with cases showing gastrointestinal polyposis, skin, hair, nail abnormalities, and hypoproteinemia.
12 citations
,
September 2018 in “International Journal of Cosmetic Science” This study demonstrated that the biomimetic peptide PTP20 may help preserve hair pigmentation and reduce greying by enhancing melanocyte function and increasing melanin production in human hair follicles.
4 citations
,
February 2022 in “Nutrients” In this study, saponins from Korean red ginseng were found to protect against the harmful effects of airborne particulate matter on human skin cells by reducing oxidative stress, inflammation, leptin expression, and melanin production.
3 citations
,
May 2020 in “Annals of the Academy of Medicine Singapore” Hair dye can cause serious scalp issues, including skull erosion.