10 citations
,
January 1967 in “PubMed” This research reports that oral contraceptives may cause melasma in 24-29% of users, with minimal improvement after stopping the drug and limited effectiveness of hydroquinone treatment.
3 citations
,
May 2011 in “Facial plastic surgery clinics of North America” This article reviews the causes and treatments of fine rhytids, highlighting the potential effectiveness of laser rejuvenation therapies but presents no new clinical results.
15 citations
,
November 2017 in “JAAD Case Reports” This study reports no known changes in hair pigmentation associated with brentuximab vedotin, despite its various other documented adverse effects.
31 citations
,
November 2015 in “PloS one” In this study, modulating Tyrosinase expression altered mouse coat color by affecting melanosome accumulation, indicating that melanosome maturity plays a role in determining skin and hair color beyond total melanin content.
19 citations
,
August 2020 in “Gastroenterology report” This review discusses the characteristics and challenges in treating Cronkhite–Canada syndrome but reports no new clinical findings, emphasizing the need for better understanding and uniform treatment approaches.
15 citations
,
November 2015 in “Trends in biotechnology” This article discusses strategies for changing hair color by regulating target genes in hair follicles using advanced delivery systems, but it reports no new experimental findings.
3 citations
,
October 2019 in “JAAD Case Reports” This review discusses different forms and patterns of alopecia associated with lupus erythematosus and reports no new clinical results; the authors highlight distinct features of these conditions.
June 2026 in “Wiadomości Lekarskie” This study found that patients undergoing endocrine surgery commonly experienced hormonal disorders and dermatologic complications, particularly those with hormonal imbalances, highlighting the importance of dermatologic surveillance and aesthetic rehabilitation in postoperative care to improve quality of life.
March 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This paper documents a case of natural reversal of moderate-to-severe androgenetic alopecia without medical intervention, but emphasizes it is an individual observation not generalizable to broader populations.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” In this documented case report, the researcher detailed a natural reversal of moderate-to-severe androgenetic alopecia without any medical interventions by systematically observing and analyzing hair regrowth over time, emphasizing that these findings are purely from personal practice and not applicable to broader populations.
November 2023 in “Frontiers in cell and developmental biology” This source reviews mechanisms and existing treatments for hair aging, highlighting factors like oxidative stress and DNA repair defects that affect hair follicle and stem cell function, and discusses research limitations and future directions in the field.
Skin changes throughout life, from development before birth to aging effects like wrinkles, influenced by both genetics and environment.
November 2010 in “International Journal of Dermatology and Venereology” This article discusses the clinical manifestations and management strategies of skin side effects from epidermal growth factor receptor inhibitors, but reports no new clinical findings.
September 1999 in “The Journal of The British Menopause Society” This review discusses how menopause and hormone replacement therapy affect skin aging in women but reports no new clinical findings.
September 1998 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This paper reviews the diverse skin, nail, and hair changes caused by medications, highlighting hyperpigmentation, alopecia, and nail structural alterations, but reports no new data.
5 citations
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February 2012 in “Australasian Journal of Dermatology” This case report documents two instances of red-haired men with patch-type alopecia areata, where hair regrowth occurred in black rather than red, an unusual phenomenon potentially linked to pigmentation and receptor pathways.
COVID-19 might cause gray hair to regain color.
December 1951 in “Journal of the American Medical Association” This article reports a case of hair loss and pigmentation changes in a man after using propylthiouracil alongside iodine solution for thyroid and diabetic conditions, providing clinical observations without broader conclusions.
62 citations
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December 1941 in “Experimental biology and medicine” In this study, phenylthiocarbamide intake was associated with hair graying in rats, while switching to tap water led some rats to regain their original fur color, suggesting dietary factors influence pigmentation.
32 citations
,
August 2003 in “Journal of the European Academy of Dermatology and Venereology” This article reviews the clinical aspects and potential mechanisms of chronic graft vs host disease skin manifestations, describing a novel form of premature skin aging, but presents no new research findings.
29 citations
,
June 2016 in “Experimental Dermatology” This study provides suggestive evidence that duplications in the MCHR2 gene may be involved in the pathogenesis of alopecia areata.
2 citations
,
December 2025 in “Cosmetics” This review reports on the effects of aging on hair characteristics such as pigmentation, growth, and structural properties across genders and ethnicities, highlighting the importance of scalp health and suggesting cosmetic solutions to improve the appearance of aged hair.
January 2026 in “Journal of Investigative Dermatology” This study found that 3D imaging may serve as a promising tool for objectively evaluating facial vitiligo repigmentation after treatment with upadacitinib.
January 2025 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that rhamnose can restore hair-inducing gene expression in dermal papilla cells and accelerate hair follicle regeneration by promoting the hair cycle into the anagen phase, suggesting its potential therapeutic application for alopecia treatment.
May 2024 in “Asian Journal of Medical Sciences” This study observed that in patients with primary hypothyroidism, common skin conditions like altered skin texture, dry skin, and diffuse hair loss may emerge before a biochemical diagnosis, suggesting these signs should prompt consideration of hypothyroidism.
April 2024 in “Pigment cell & melanoma research” This study explored the diversity of melanocyte stem cell subpopulations in the hair follicles of adult female mice and identified novel groups with distinct immune privilege regulation, suggesting a heterogeneous landscape that future research should consider.
November 2019 in “European journal of internal medicine” This report documents a case of Cronkhite-Canada Syndrome in a 56-year-old Laotian man, who successfully improved with vitamin supplementation and medical treatment after experiencing weight loss, alopecia, and gastrointestinal polyposis.
February 2008 in “Experimental dermatology” This article reviews potential pathomechanisms of vitiligo, emphasizing membrane alterations involving cholesterol and cardiolipin, but reports no new clinical findings.
January 2004 in “Banca y finanzas: Revista profesional de gestión financiera” This study found that 5 alpha-dihydrotestosterone increased pigmentation in dorsal spots and scrotal skin of prepubertal male Syrian hamsters, while estradiol decreased scrotal skin melanocytes and reversed androgen-induced pigmentation in costovertebral spots.
January 2003 in “Journal für Kardiologie (Krause & Pachernegg GmbH)” This review discusses the dermatological impacts of hypogonadism in men, including skin thinning, reduced body hair, and skin reactions to testosterone therapy, but reports no new clinical results.