12 citations
,
November 1945 in “Archives of dermatology” In this study, hair color changes in piebald rats after skin grafting suggest that such changes are more likely due to the surgical process than the new environment.
12 citations
,
September 1981 in “Acta Dermato Venereologica” This case study reports that oral zinc therapy improved hair growth and pigmentation in a young girl with sucrase deficiency and low zinc levels.
January 2016 in “Lithuanian University of Health Sciences” This study in a Lithuanian veterinary clinic observed diverse histomorphological skin changes in alopecic dogs caused by various rare diseases, including hyperkeratinization and pigmentation disorders.
11 citations
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April 2013 in “Homo” In this study, 7-10-year-old Polish children showed a significant increase in skin pigmentation levels, with girls exhibiting this change more prominently than boys, suggesting an early sign of puberty.
1 citations
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December 2019 This study found that bimatoprost eye drops significantly increased eyelash length, thickness, pigmentation, and the number of eyelashes per follicle in rabbits within one month.
September 2024 in “Digital Commons - University of South Florida (University of South Florida)” This study found that injecting various hormones or hormone-cholesterol mixtures into Willow Ptarmigan and White-tailed Ptarmigan led to the growth of pigmented feathers instead of the usual white winter feathers, suggesting hormonal influence on plumage color changes.
1 citations
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September 2024 in “Journal of Oncology Pharmacy Practice” In this report, a 77-year-old woman treated for essential thrombocytosis with low-dose hydroxyurea experienced an unexpected change in hair color from gray to dark brown after 20 weeks, highlighting a potential aesthetic side effect of the drug, in addition to therapeutic effects.
12 citations
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April 1990 in “PubMed” This review discusses physiologic skin changes and various dermatoses associated with pregnancy but reports no new clinical findings, highlighting limited understanding of some conditions' etiologies.
March 2011 in “Pigment Cell & Melanoma Research” This study found that changes in the expression of the Agouti gene contribute to the pale pigmentation in beach mice, with implications for melanocyte development and localization.
74 citations
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March 1963 in “Archives of Dermatology” This article reviews historical reports of skin changes, such as pseudoacanthosis nigricans, associated with cholesterol-lowering drugs like triparanol and nicotinic acid, but presents no new clinical findings.
7 citations
,
January 2021 in “Frontiers in genetics” This study suggests an association between DNA methylation changes in hair follicles and inherited color dilution in Rex rabbits, contributing to a deeper understanding of epigenetic influences on rabbit pigmentation.
57 citations
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July 2005 in “Genetics” In this study on Drosophila wings, researchers identified 435 genes with significant expression changes during wing hair morphogenesis, and found new phenotypes for 9 genes through functional validation.
1 citations
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January 2013 in “Springer eBooks” The document concludes that skin and nail changes can indicate various underlying health conditions.
September 2018 in “PubMed” This review discusses the aging-related changes in hair properties, their impact on styling, and potential interventions, without providing new clinical results.
22 citations
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September 2019 in “Trends in Immunology” This paper proposes that acne vulgaris is a transient inflammatory response during adolescence due to changes in facial skin's microbiota and sebum environment rather than a stable skin condition.
January 2005 in “Chinese Journal of Veterinary” This study observed that hairless mice of different strains initially grow hair but soon develop alopecia and other skin and pigmentation changes with age.
1 citations
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January 2020 in “Research Square (Research Square)” This study found that inherited color dilution in Rex rabbit hair follicles is associated with DNA methylation changes, contributing to understanding the epigenetic regulation of rabbit pigmentation.
This study observed that the development of the pars intermedia in long-tailed macaques is closely associated with changes in skin pigmentation during pre- and postnatal periods through melanocyte-stimulating hormone and ACTH activity.
March 2026 in “Biomedicines” This study found that the Antera 3D® system provided an objective and sensitive method for assessing pediatric pathological scars, capturing significant changes in pigmentation, vascularity, and volume, compared to the traditional Vancouver Scar Scale and dermoscopy, which showed varied sensitivities across different scar parameters.
47 citations
,
July 1967 in “Science” This study observed morphological changes in scalp hair follicles of humans deprived of protein for 15 days, which suggests potential use in diagnosing protein-calorie malnutrition.
21 citations
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December 2023 in “Journal of Investigative Dermatology” This study highlights multiple factors contributing to hair graying, such as oxidative damage, melanocyte changes, and genetic influences, and suggests that repigmentation may be temporarily reversible, offering potential targets for future treatments while urging caution when applying mouse model findings to humans.
2 citations
,
March 2020 in “Developmental cell” This study reported that stress can induce hair graying in mice through noradrenaline-mediated depletion of melanocyte stem cells in hair follicles, providing a mechanism that connects stress to hair color changes.
December 2004 in “Medicine” This review examines different skin conditions during pregnancy, including physiological changes and pregnancy-exclusive dermatoses, and reports no new clinical findings.
January 2000 in “Cambio 16” This study observed that overexpression of Bcl-2 in certain transgenic mice accelerates catagen progression and increases hair follicle apoptosis and alopecia, while Bcl-2 deficient mice show delayed hair growth and pigmentation changes.
12 citations
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August 1988 in “Histopathology” This case report describes a giant pigmented tumor of the scalp in a 47-year-old woman and suggests a possible dual origin involving neural crest differentiation.
This study found that some white or grey human hairs can naturally regain pigmentation, suggesting a potential temporary reversibility of hair greying associated with stress and molecular changes.
October 2025 in “International Journal of Advanced Multidisciplinary Research and Studies” This study found that hairless dog breeds have adapted to maintain normal body and core temperatures through structural changes like a thicker epidermis and the role of melanin in thermoregulation, with genetic mechanisms involving the FOXI3 gene governing hairlessness.
450 citations
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January 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” This article reviews follicular melanogenesis, detailing how melanin synthesis and its regulation in hair follicles depend on a complex interplay of cellular and molecular mechanisms, but reports no new clinical findings.
20 citations
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October 2018 in “American Journal of Clinical Dermatology” This article reviews drug-induced pigmentation and reports no new clinical findings, highlighting difficulty in confirming drug associations due to factors like delayed onset and polypharmacy.
April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that Sox2 and BMP signaling may be key regulators of pigmentation and melanocyte migration, as suggested by experiments in mice, human biopsies, and cell co-cultures.