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This study developed a mouse model to mimic PHGDH gene copy number gain, finding that increased PHGDH expression leads to abnormal melanin production, which may offer insights into its role in melanoma.

This study found that increased PHGDH expression in mice led to earlier melanin and melanocyte presence in hair follicles but did not induce cancer.

This study found that smoking, obesity, and family history are significant risk factors for premature hair graying in young men.

This study found that premature hair graying in young Turkish men and women is associated with emotional stress, alcohol consumption, chronic diseases, and a family history of graying.

In this study, premature hair graying in Indian patients under 25 was associated with low levels of serum ferritin, Vitamin B12, and high-density lipoprotein cholesterol.

This study found that patients with premature hair graying had lower serum levels of iron, copper, and calcium, which correlated with the severity of graying.

This study found that a vegetarian diet preference, atopy history, and paternal family history were associated with a higher likelihood of premature hair graying in young adults.

In this case study, a 14-year-old female with premature hair graying showed improved hair color after treatment with a topical Melitane 5% formulation and oral hair supplements.

This review summarizes evidence suggesting that smoking is associated with alopecia and premature hair graying, with smokers showing higher prevalence than nonsmokers.

This study identified an association between premature hair greying and larger waist circumference among young healthy subjects.

This study found no significant association between premature hair graying and serum ferritin or vitamin D levels in young adult males at Universitas Sumatera Utara.

This study found that premature hair greying may be associated with low serum ferritin and raised anti-TPO levels.

In this study, premature hair graying in Egyptians was significantly linked to family history, stress, sedentary lifestyle, and low serum ferritin levels, but not to vitamin D deficiency.

This study found no significant difference in serum levels of lead and selenium between patients with premature hair graying and those without it.

This narrative review analyzed the literature on premature hair graying, identifying potential contributors such as nutrient deficiencies, oxidative and emotional stress, smoking, genetic factors, autoimmune diseases, and medication side effects, but reported no effective treatment to reverse it, underscoring the necessity for further research.

This review discusses the role of nutrients in hair graying management and finds a possible link between low copper, iron, and vitamin B12 levels and premature hair graying.

In this study, low serum ferritin levels were significantly associated with premature graying of hair, while no significant difference in vitamin D levels was observed between affected individuals and healthy controls.

This study found that individuals with premature hair graying had significantly lower levels of antioxidants compared to controls, but the severity of graying did not significantly correlate with oxidative stress levels.

This study identified new and recurrent missense mutations in the PHGDH and PSAT1 genes, implicating them in the pathogenesis of Neu-Laxova syndrome in Chinese patients.

This study found that overexpression of the metabolic enzyme PHGDH can promote cancer initiation and progression, highlighting its significant role in tumor cell proliferation and tumorigenesis.

This review examined the psychological effects, mechanisms, health associations, and treatments related to premature hair graying, highlighting factors like genetics, oxidative stress, smoking, and diet, with the aim of enhancing understanding and addressing its broader implications.

Premature gray hair may indicate reduced ovarian reserve but doesn't lower pregnancy chances.

This study observed that individuals with premature hair graying had lower levels of certain serum nutrients and lifestyle factors like stress and smoking may contribute; hair oiling appeared protective.

This review explores the potential of herbal therapies and modern delivery methods for managing premature hair greying, highlighting promising plant-based treatments and emphasizing the need for clinical trials to validate their effectiveness.

This study examines Ayurvedic approaches to managing premature hair greying, highlighting the potential of herbal formulations, lifestyle interventions, and rejuvenative therapies as safe, sustainable alternatives, though more rigorous clinical trials are needed to validate these methods.

In this study, reduced serum levels of iron, copper, and calcium were associated with premature graying of hair, suggesting that supplementation might help, but more research is needed to fully understand the relationship.

This study observed that premature hair graying was more prevalent among obese individuals, those with vitamin B12 and D deficiencies, smokers, and people with high stress, regardless of whether they were medical or non-medical students at a university in Saudi Arabia.

This article reports a rare combination of rapid-onset halo nevi, nonsegmental vitiligo, and premature scalp hair graying.

This paper explores how hair functions as a geographical lens to redefine the body's borders, influencing perceptions of identity and power.

In this study, most participants began using chemical hair dyes at a young age, experiencing adverse effects, but continued due to the perceived importance of hair color.