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    Glossary Peripheral Blood Mononuclear Cells

    blood cells with a single round nucleus, like lymphocytes and monocytes

    Peripheral Blood Mononuclear Cells (PBMCs) are a type of blood cell that has a single round nucleus, such as lymphocytes (T cells, B cells, NK cells) and monocytes. These cells are crucial for the immune system, as they play key roles in immune response and are often used in research and clinical studies to understand various diseases, including autoimmune disorders and infections.

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    1. Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata British Journal of Dermatology · 2011 · 48 citations
    2. Altered expression of intracellular Toll-like receptors in peripheral blood mononuclear cells from patients with alopecia areata BBA clinical · 2016 · 12 citations
    3. Impaired responses of peripheral blood mononuclear cells to T-cell stimulants in alopecia areata patients with a poor response to topical immunotherapy 2008 · 4 citations
    4. Ex Vivo Treatment with Allogenic Mesenchymal Stem Cells of a Healthy Donor on Peripheral Blood Mononuclear Cells of Patients with Severe Alopecia Areata: Targeting Dysregulated T Cells and the Acquisition of Immunotolerance International Journal of Molecular Sciences · 2022 · 1 citations
    5. Uncontrolled Clinical Trial of Quality- and Quantity-cultured Peripheral Blood Mononuclear Cell Treatment for Androgenic Alopecia Plastic & Reconstructive Surgery · 2025
    6. 058 Subset analysis of NKG2D+ cells in peripheral blood mononuclear cells 2023
    7. 302 Availability of mRNA Obtained from Peripheral Blood Mononuclear Cells for Mutational Analysis in Dystrophic Epidermolysis Bullosa Journal of Investigative Dermatology · 2022
    8. TO IDENTIFY THE EXPRESSION OF INTRACELLULAR TOLL-LIKE RECEPTORS (TLRS) IN PERIPHERAL BLOOD MONONUCLEAR CELLS OF ALOPECIA AREATA 2023
    9. The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring Pharmaceutics · 2023 · 1 citations
    10. Apoptosis resistance in peripheral blood lymphocytes of alopecia areata patients Journal of Autoimmunity · 2004 · 38 citations
    11. Table 1_Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areata.docx Figshare · 2025
    12. 004 Cell-based therapy may be effective in alopecia areata: Preclinical evidence that autologous, peripheral regulatory γdT cells are preventive in human ex vivo and therapeutic in human in vivo models Journal of Investigative Dermatology · 2022
    13. scMC learns biological variation through the alignment of multiple single-cell genomics datasets Genome biology · 2021 · 822 citations
    14. Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege Journal of Investigative Dermatology · 2013 · 53 citations
    15. iNKT cells ameliorate human autoimmunity: Lessons from alopecia areata Journal of autoimmunity · 2018 · 27 citations
    16. Immortalized human hair follicle-derived mesenchymal-like stromal cells for the long-term production of scalable Immunomodulatory and regenerative secretome Stem Cell Research & Therapy · 2025 · 1 citations
    17. 049 Investigating the immunomodulatory mechanism of dithranol in alopecia areata through blood-based in vitro studies Journal of Investigative Dermatology · 2025
    18. 164 Epigenetic and transcriptional profiling of PBMCs in mild and severe alopecia areata using single-cell RNA-Seq and ATAC-Seq Journal of Investigative Dermatology · 2023
    19. 165 Single-cell RNA sequencing analysis unveils highly active yet diminished CD14+CD16- circulating monocytes, independent of alopecia areata severity Journal of Investigative Dermatology · 2023
    20. 586 Increase in CD8+ effector memory cells re-expressing CD45RA (TEMRA) reflects disease activity and enables early prediction of therapeutic outcome in rapidly progressive alopecia areata Journal of Investigative Dermatology · 2023
    21. Disturbance of the Circadian System in Shift Work and Its Health Impact Journal of biological rhythms · 2021 · 103 citations
    22. Autoimmune Disease Induction in a Healthy Human Organ: A Humanized Mouse Model of Alopecia Areata Journal of Investigative Dermatology · 2012 · 75 citations
    23. The PDE4 inhibitor, apremilast, suppresses experimentally induced alopecia areata in human skin in vivo Journal of Dermatological Science · 2014 · 52 citations
    24. Novel TMEM173 Mutation and the Role of Disease Modifying Alleles Frontiers in immunology · 2019 · 47 citations
    25. Somatostatin Expression in Human Hair Follicles and Its Potential Role in Immune Privilege 2013 · 27 citations
    26. A New Humanized Mouse Model for Alopecia Areata Journal of Investigative Dermatology Symposium Proceedings · 2013 · 25 citations
    27. Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 MKG2D Lymphocytes of Alopecia Areata Patients 2018 · 15 citations
    28. Increased CRHR1 expression on monocytes from patients with AA enables a pro‐inflammatory response to corticotrophin‐releasing hormone Experimental Dermatology · 2024 · 3 citations
    29. Large-Scale Epitope Identification Screen and Its Potential Application to the Study of Alopecia Areata 2017 · 2 citations
    30. Characterization of novel TMEM173 mutation with additive IFIH1 risk allele bioRxiv (Cold Spring Harbor Laboratory) · 2018 · 1 citations