research 17α-Acetoxy-6-bromo-16β-methylpregna-4,6-diene-3,20-dione
This study describes the molecular conformation and intermolecular interactions in the crystalline structure of the compound C24H31BrO4.
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research Fabrication and Characterization of Dissolving Microneedles Containing Oryza sativa L. Extract Complex for Enhancement of Transfollicular Delivery
This study observed that dissolving microneedles made from PVP-K90 and HPMC E50, incorporating Oryza sativa L. extract complex, showed enhanced transfollicular skin penetration and maintained safety for keratinocytes, with the P25H5 formulation demonstrating faster dissolution and greater effectiveness.
research Roles of Type 10 17beta-Hydroxysteroid Dehydrogenase in Intracrinology and Metabolism of Isoleucine and Fatty Acids
This article discusses the functions of the enzyme 17beta-HSD10, including its role in steroid metabolism and potential links to Alzheimer's disease, but reports no new experimental findings.
research miR-761-hepcidin/Gpx4 pathway contribute to unexplained liver dysfunction in polycystic ovary syndrome by regulating liver iron overload and ferroptosis
In this study, researchers found that unexplained liver damage in PCOS patients may involve iron metabolism and the miR-761-hepcidin/GPX4 axis, suggesting potential therapeutic targets.
research 008 Development of a Humanized Mouse Model of Vitiligo
research Safety, tolerability, and PK of topical calcitriol formulation for treatment of chemotherapy-induced alopecia (CIA) in patients receiving taxane-based regimen: Final results.
This Phase 1 study reported that topical application of BPM31543 was safe and well-tolerated in patients receiving taxane-based chemotherapy, with some experiencing less than 50% hair loss, suggesting potential efficacy in reducing chemotherapy-induced alopecia, although no maximum tolerated dose was identified.
research The Case Files
This case report describes the diagnosis of pseudoporphyria in a hemodialysis patient, highlighting the importance of discontinuing causative medications and advising patients on sun protection to manage this photosensitive condition.
research Use of diphenylcyclopropenone for alopecia areata treatment during pregnancy
This article reviews DPCP's use as a topical immunotherapy for alopecia areata and discusses its suggested mechanism, but reports no clinical results.