research Molecular Genetic Dissection of ILVEN Leads to Successful Targeted Therapy
Targeted therapy with Ustekinumab significantly improved a skin condition called ILVEN, which is caused by mutations in the CARD14 gene.
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research Specialized Ribosomes in Human Dermal Fibroblast Senescence
Specialized ribosomes affect aging in human skin cells.
research Hair Removal
Electrolysis and laser treatments offer more permanent hair removal, but have limitations.
research Distribution of Polyamines May Be Altered in Different Scalp Regions of Patients with Hair Loss
Hair loss patients may have different polyamine levels in various scalp areas.
research Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase
Overexpressing a specific enzyme in mice causes hair loss and female infertility.
research Laser Hair Removal: Principles, Techniques, and Advances
Laser hair removal is the most requested cosmetic procedure and has become a scientifically-based treatment suitable for all skin types.
research Characteristics of Flutamide Action on Prostatic and Testicular Functions in the Rat
Flutamide combined with an LHRH agonist effectively inhibits prostate growth, suggesting it could treat prostate cancer.
research Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions
Spermidine may help reduce hair loss and deserves further testing as a treatment.
research Androgens and Hair Loss: An In-Depth Analysis of Androgenetic Alopecia
The document concludes that hair transplantation and gene therapy may be important for future hair loss treatment.
research Different Polyamine Levels in the Vertex and Occipital Hair of Pattern Hair Loss Patients
People with pattern hair loss have higher polyamine levels in the top of their head compared to the back.
research Abstract 2474: The Mechanistic Role of Polyamines in DNA Double-Strand Break Repair
Polyamines help repair DNA breaks and may influence cancer development.
research Novel De Novo Pathogenic Variant in the ODC1 Gene in a Girl with Developmental Delay, Alopecia, and Dysmorphic Features
A new genetic mutation in the ODC1 gene causes developmental delay and other symptoms in a young girl.
research Spermidine/Spermine-N1-Acetyltransferase: A Key Metabolic Regulator
SSAT is a key enzyme affecting cell growth and metabolism, with potential but risky use in disease treatment.
research In This Issue
The studies identified key factors and potential treatments for skin and hair disorders.
research Hair Removal
Current hair removal methods improve appearance but need more research for better options.
research Activated Polyamine Catabolism Depletes Acetyl-CoA Pools and Suppresses Prostate Tumor Growth in TRAMP Mice
Overexpressing SSAT enzyme reduces prostate tumor growth in mice.
research A Transition State Analogue of 5′-Methylthioadenosine Phosphorylase Induces Apoptosis in Head and Neck Cancers
MT-DADMe-ImmA can selectively kill head and neck cancer cells without harming normal cells.
research Ex-Vivo Evaluation of Eflornithine Hydrochloride Loaded Solid Lipid Microparticles Based Cream
The EFH-SLM cream is more effective and gentler for treating excessive hair growth in women.
research Endocrinology Update: Hirsutism
Hirsutism involves excessive hair growth due to hormonal issues and can be treated with medication or surgery.
research Diagnosis and Treatments of Hirsutism: Where Are We?
Effective treatments for excessive hair growth in women include creams, laser therapy, and medications, with the choice depending on individual needs and potential side effects.
research Expression of Matrix Metalloproteinases and Tissue Inhibitor of Matrix Metalloproteinases in the Hair Cycle
MMP-2 and MMP-9 help hair grow, while their inhibitors peak when hair growth slows.
research Promotion of Homology-Directed DNA Repair by Polyamines
Polyamines help fix DNA damage accurately in cells.
research Disturbed Keratinocyte Differentiation in Transgenic Mice and Organotypic Keratinocyte Cultures Due to Spermidine/Spermine N1-Acetyltransferase Overexpression
Overexpression of SSAT causes hair loss and skin issues, but reducing putrescine can help.
research Evaluation of Tolerance and Trichological Efficacy of a Food Supplement in Men and Women with Telogen Effluvium-Like Disorder
The food supplement improved hair growth and strength in people with a certain type of hair loss and had no major side effects.
research Effect of Minoxidil on Cultured Keratinocytes
Minoxidil helps hair cells live longer and grow longer.
research Indian Gooseberry (Emblica Officinalis Gaertn.) Pharmacological Properties
Indian Gooseberry has potential for cancer prevention and treatment and promotes hair growth.
research A Method to Improve the Efficacy of Topical Eflornithine Hydrochloride Cream
Using microneedles before applying eflornithine cream can make it more effective at stopping hair growth.
research Does Eflornithine Help Women Face Hirsutism?
Eflornithine's effectiveness for women with facial hirsutism is unclear.
research Androgens and Hair: A Biological Paradox with Clinical Consequences
Androgens can both increase body hair and cause scalp hair loss.
research Approach to the Adult Female Patient with Diffuse Nonscarring Alopecia
The document concludes that careful evaluation is key to diagnose and treat women with hair loss, with tests for thyroid, iron, and hormones as needed.