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    Glossary Oral JAK Inhibitors

    medications taken orally that block Janus kinase enzymes

    Oral JAK Inhibitors, also known as oral Janus kinase inhibitors or oral JAKis, are medications taken by mouth that block the activity of Janus kinase enzymes. These enzymes play a key role in the signaling pathways that regulate immune responses and inflammation. By inhibiting these enzymes, oral JAK inhibitors can help manage autoimmune conditions and inflammatory diseases, including certain types of alopecia, by reducing abnormal immune activity.

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    1. Safety of oral JAK inhibitors in treating alopecia areata: a systematic review and network meta-analysis Frontiers in Pharmacology · 2025 · 3 citations
    2. Comparative efficacy and safety of systemic steroids, oral JAK inhibitors and Contact Immunotherapy in the Treatment of severe alopecia areata: a systematic review and network meta-analysis Archives of Dermatological Research · 2024 · 3 citations
    3. 18883 Androgenetic alopecia pattern hair regrowth in patients with alopecia areata treated with oral JAK inhibitors Journal of The American Academy of Dermatology · 2020
    4. When JAK inhibitors are off the table: durable remission of severe alopecia areata with dexamethasone oral mini-pulse and a focused review Journal of Dermatological Treatment · 2025
    5. JAK Inhibitor Baricitinib in the Treatment of Oral Lichen Planus: A Case Report 2024
    6. 77200 Infections and Therapy Lapses Predominate as Flare Triggers on Oral JAK Inhibitors for Alopecia Areata: A Retrospective Cohort Study Journal of the American Academy of Dermatology · 2026
    7. Treatment of Alopecia Areata with Oral JAK Inhibitor : Focusing on Clinical Outcomes with Baricitinib The Nishinihon Journal of Dermatology · 2022 · 1 citations
    8. BH19 ‘JAK in the box?’ Long-term safety concerns with oral Janus kinase inhibitors for alopecia areata British Journal of Dermatology · 2025
    9. The development of oral hairy leukoplakia during JAK inhibitor baricitinib therapy JAAD case reports · 2023
    10. Clinical and Dermoscopic Evaluation of the Safety and Efficacy of Oral baricitinib (JAK Inhibitor) in Treatment of Localized Vitiligo Either Alone or with Topical Tacrolimus The Egyptian Journal of Hospital Medicine · 2025
    11. 75360 Nasal hair (vibrissae) involvement in patients with alopecia areata universalis: preliminary results showing density modification and response to oral JAK inhibitors Journal of the American Academy of Dermatology · 2026
    12. The efficacy and safety of JAK inhibitors for alopecia areata: A systematic review and meta-analysis of prospective studies Frontiers in pharmacology · 2022 · 37 citations
    13. Jak inhibitors in the treatment of alopecia areata - a literature review Journal of Education Health and Sport · 2025
    14. Comparative efficacy and safety of JAK inhibitors in the treatment of moderate-to-severe alopecia areata: a systematic review and network meta-analysis Frontiers in pharmacology · 2024
    15. Efficacy and Safety of Oral Janus Kinase Inhibitors in Adults and Adolescents with Alopecia Areata: A Systematic Review and Meta-Analysis of Randomised Controlled Trials American Journal of Clinical Dermatology · 2026
    16. Use of oral Janus kinase inhibitors for the treatment of severe alopecia areata: narrative review and real-world experience Immunological Medicine · 2026
    17. 151 Efficacy and adverse effects of oral Janus kinase inhibitor (JAKi) use in patients with lichen planopilaris: a retrospective case series and systematic review 2023
    18. Emerging drugs for alopecia areata: JAK inhibitors Expert opinion on emerging drugs · 2018 · 20 citations
    19. 544 Alopecia areata lesions show significant changes in immune and keratin biomarkers that correlate with clinical improvement with oral Janus kinase inhibitors PF-06651600 (JAK3) and PF-06700841 (TYK2/JAK1) Journal of Investigative Dermatology · 2019 · 5 citations
    20. Tratamento adjuvante com minoxidil oral para tratamento de alopecia areata refratária a inibidores de JAK Surgical & Cosmetic Dermatology · 2020 · 1 citations
    21. JAK inhibitors in dermatology: The promise of a new drug class Journal of the American Academy of Dermatology · 2017 · 355 citations
    22. P123 : Oral Janus kinase inhibitors for the treatment of alopecia areata: a systematic review and metaanalysis 프로그램북(구 초록집) · 2019
    23. JAK inhibitors for alopecia areata: a systematic review and meta‐analysis 2019 · 130 citations
    24. JAK-inhibitors in dermatology: current evidence and future applications Journal of dermatological treatment · 2018 · 45 citations
    25. BH21 Efficacy and safety of oral Janus kinase inhibitors in the treatment of alopecia areata: a systematic review and meta-analysis British Journal of Dermatology · 2026
    26. Effectiveness and safety of oral Janus kinase inhibitors in patients aged ≤12 with alopecia areata: a systematic review and meta-analysis Mendeley Data · 2026
    27. SYSTEMATIC REVIEW OF ORAL JANUS KINASE INHIBITORS IN ALOPECIA AREATA: INSIGHTS FROM 2020 TO 2025 STUDIES International Journal of Innovative Technologies in Social Science · 2025
    28. 44182 Treatment with Oral Janus Kinase Inhibitors in Adults Patients with Alopecia Areata: A Systematic Review and Meta-Analysis Journal of the American Academy of Dermatology · 2023
    29. Comparative efficacy of oral Janus kinase inhibitors and biologics in adult alopecia areata: A systematic review and Bayesian network meta‐analysis Journal of the European Academy of Dermatology and Venereology · 2024 · 20 citations
    30. 378 Treatment of severe alopecia areata with the oral Janus kinase inhibitor, tofacitinib: A retrospective chart review Journal of Investigative Dermatology · 2017 · 1 citations