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The vitamin D receptor can act without its usual activating molecule, affecting hair growth and skin cancer, but its full range of actions is not well understood.

Intermediate filaments are crucial for cell differentiation and stem cell function.

The Hedgehog Signaling Pathway is important for skin and hair development and skin cancer treatment, but more research is needed to understand it fully.

The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.

The extracellular matrix affects where tumors can start in the body.

Some people with primary cicatricial alopecia also have inflammatory bowel disease, suggesting a possible connection.

TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.

Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.

Removing both Atr and Trp53 genes in adult mice causes severe tissue damage and death due to DNA damage.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

Targeted cancer therapies often cause skin problems that need careful management to improve patient quality of life and treatment success.

RNA aptamers can specifically block FGF5-related cell growth, potentially treating related diseases or hair disorders.

Genetic mutation and carcinogen treatment are both needed for skin cancer to develop in these specific mice.

Removing Sprouty genes in mice causes various hormone-related issues but does not increase cancer risk by one year of age.

Maintaining DNA integrity in stem cells is crucial to prevent aging and cancer.

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Cancer cells often have more copies of TERT and TERC genes, which helps them grow and could affect patient outcomes.

Male hormones like testosterone may make COVID-19 worse, and testing for sensitivity to these hormones could help predict how severe a patient's symptoms might be. Treatments that reduce these hormones are being explored.

MIM is crucial for hair follicle formation and regeneration by controlling cilia formation and hedgehog signaling through its interaction with Cortactin and Src.

Maintaining DNA health in stem cells is key to preventing aging and tissue breakdown.

Older skin has higher cancer risk due to inflammation and stem cell issues.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Targeted cancer therapies have a significant but lower risk of causing hair loss compared to chemotherapy.

The gene p53 is crucial for removing damaged cells to allow for healthy tissue renewal.

Patients with GATA2 deficiency show early skin symptoms that help diagnose the condition.

The document concludes that veterinary dermatologists need more experience and a better approach to treating skin diseases in nonhuman primates.

The research suggests that autophagy-related genes might play a role in causing alopecia areata.

Understanding how epigenetic regulation affects stem cells is key to cancer insights and new treatments.

The article concludes that hair loss is a common side effect of drugs treating skin cancer by blocking the hedgehog pathway, but treatment should continue, and more selective drugs might prevent this side effect.