67 citations
,
April 1988 in “The Journal of Clinical Endocrinology & Metabolism” This study describes a family with X-linked gynecomastia and undervirilization in men, finding a subtle androgen receptor abnormality that may not always lead to infertility despite androgen resistance.
54 citations
,
September 2013 in “Fertility and Sterility” This study found that discontinuing finasteride led to a significant increase in sperm counts for most men with reduced fertility, though hormone levels and other semen parameters remained unchanged.
44 citations
,
April 2015 in “PubMed” This study reports that clinical trials of finasteride for androgenic alopecia provide insufficient and systematically biased safety data, with most participants unrepresentative of those in pivotal trials that led to FDA approval.
30 citations
,
June 2012 in “Current Opinion in Endocrinology, Diabetes and Obesity” This review discusses the pathophysiology, genetics, and management of nonclassic congenital adrenal hyperplasia, noting subfertility and hormonal issues without providing new clinical results.
29 citations
,
December 2012 in “Current Opinion in Endocrinology, Diabetes and Obesity” This review discusses factors affecting fertility in both men and women with congenital adrenal hyperplasia and emphasizes individualized preconception management but reports no new clinical results.
26 citations
,
October 2014 in “Andrologia” This review discusses the risk factors and implications of sperm aneuploidy in males, and it reports no new clinical results; the authors highlight the importance of personalized assessment in assisted reproduction.
8 citations
,
January 2017 in “Fertility and Sterility” This article reviews the impact of aging and related urologic conditions on male fertility, highlighting the effects of various treatments on sperm parameters and recommending pre-treatment counseling for fertility preservation. It reports no new clinical results.
5 citations
,
December 2012 in “PubMed” This study describes the first reported case of a successful full-term pregnancy and live birth after long-term use of finasteride, suggesting it may not prevent normal conception despite initial severe oligospermia after discontinuation.
5 citations
,
August 1987 in “Andrology” This study found that salivary testosterone levels were significantly lower in oligospermic and azoospermic men compared to normal men, suggesting its potential use in assessing male androgen status.
2 citations
,
September 2007 in “Fertility and Sterility” This study reported significant improvements in sperm concentration in two cases of azoospermia and severe oligospermia after discontinuing finasteride 1 mg used for hair loss.
1 citations
,
August 2013 in “Fertility and Sterility” Finasteride may improve sperm count in subfertile men with low sperm count.
February 2024 in “The Journal of Sexual Medicine” This study suggests that 5α-reductase inhibitors do not significantly affect male reproductive function but may require caution in men with oligospermia or ejaculatory issues.
82 citations
,
September 1983 in “Clinics in Gastroenterology” Zinc is vital for health, and its deficiency can worsen gastrointestinal and liver diseases.
2 citations
,
January 2004 in “Korean Journal of Andrology” 
1 citations
,
January 2010 in “Clinica Veterinaria De Pequenos Animales” In this case report, treatment with antibiotics, finasteride, and prostate omentalization restored fertility in a 6-year-old German Shepherd with prostatitis and astenoteratozoospermia, avoiding surgical castration.
2 citations
,
January 2011 in “Yearbook of Urology” Stopping finasteride can improve sperm count in infertile men.
38 citations
,
December 2010 in “Fertility and Sterility” In this case report, a male patient's semen parameters improved after discontinuing a 1-mg dose of finasteride, suggesting that stopping the medication may benefit infertile men with previous sperm production issues.
December 2021 in “International Journal of Science and Research (IJSR)” This review discusses Khalitya as described in Ayurvedic texts in relation to androgenetic alopecia and highlights the limitations and side effects of current modern treatments, but reports no new clinical results.
13 citations
,
September 2011 in “International Urology and Nephrology” 
January 2024 in “Wiadomości Lekarskie” In this study, researchers analyzed spermogram data from men with diagnosed infertility in Ukraine, aiming to identify the most common sperm disorders, and they found that the study primarily involved men with primary infertility, compared to a control group of healthy men with confirmed fertility.
1 citations
,
September 2013 in “Fertility and Sterility” Finasteride discontinuation increases sperm count in men.
2 citations
,
December 2016 in “Clinical and Experimental Obstetrics & Gynecology” This study found that women with PCOS and factors like primary infertility, familial history of type 2 diabetes, and specific lipid profiles tend to have less favorable fertility treatment outcomes.
May 2025 in “Gynecological Endocrinology” This study observed that men with a family history of PCOS had lower median sperm concentration and higher rates of alopecia and gynecomastia compared to those without such a family history.
49 citations
,
December 2007 in “Fertility and Sterility” This case report describes two infertile patients who experienced significant improvements in sperm concentrations six months after stopping finasteride.
55 citations
,
July 2013 in “Dermatologic therapy” This review explores the impact of various medications on male fertility, highlighting reversible negative effects from methotrexate, finasteride, and ketoconazole, while reporting no adverse fertility effects for oral retinoids and certain immunosuppressants.
36 citations
,
July 2014 in “Neuromuscular Disorders” This study investigated a patient with spinal and bulbar muscular atrophy who had 68 CAG repeats, revealing early onset and unique symptoms not previously documented in the condition.
31 citations
,
July 2004 in “Molecular Medicine” This study found that mutant glucocorticoid receptors have defective transcriptional activity and dynamic motility issues in the nucleus, likely due to impaired interactions with nuclear molecules necessary for gene activation.
2 citations
,
July 2019 in “Journal of psychology & clinical psychiatry” This article discusses the role of zinc in reducing depression severity and reports no new research findings, emphasizing the need for further investigation into its therapeutic potential.
1 citations
,
January 2011 in “Journal of Human Reproductive Sciences” Finasteride may decrease semen quality but not harm sperm production, and stopping the drug can improve semen quality; hyperprolactinemia can cause infertility but is treatable with medication.
December 2021 in “International Journal of Science and Research (IJSR)” This study explored Ayurvedic treatments for Khalitya (Alopecia areata) and found that using Virechana Karma, along with systemic medicines and Rasayan drugs, may be extremely beneficial in managing this condition.