October 2024 in “GE Portuguese Journal of Gastroenterology” This case report describes a 78-year-old male with adenocarcinoma and Hypertrichosis lanuginosa acquisita, highlighting the need to consider malignancy in patients with unexplained excessive hair growth.
2 citations
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July 2001 in “Dermatologic Surgery” This study reports two cases of trichoblastic neoplasms with histologic features suggesting they may be distinct, locally aggressive trichoblastic carcinomas separate from basal cell carcinoma.
35 citations
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March 2012 in “Experimental and Clinical Endocrinology & Diabetes” This article discusses various causes of hyperandrogenism in women and highlights diagnostic considerations for conditions such as PCOS, NCCAH, Cushing's disease, and androgen-secreting tumors, without reporting new clinical results.
April 2020 in “Journal of the Endocrine Society” This case report highlights Leydig cell hyperplasia as a rare cause of increased testosterone and postmenopausal hirsutism, resolved after bilateral salpingo-oophorectomy in a 64-year-old woman.
This case report describes a 65-year-old postmenopausal woman with hyperandrogenism caused by a non-malignant ovarian Leydig cell tumor, which is a rare cause of virilization.
January 2017 in “University journal of surgery and surgical specialities” This case study describes a rare steroid cell tumor of the ovary in a 42-year-old woman, highlighting its virilizing effects and the importance of thorough follow-up due to its potential for malignancy.
2 citations
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April 2012 in “American Journal of Dermatopathology” This report describes two cases of nevus lipomatosus superficialis with the unusual feature of dilated hair follicles, emphasizing the need for precise histopathological diagnosis to differentiate from similar conditions.
September 2020 in “Advances in anatomic pathology” In this case report, a preoperative core biopsy for a giant rhinophyma provided a misleading diagnosis, and the authors suggest such biopsies may be unnecessary.
October 1967 in “Archives of Dermatology” This report discusses a case of an intradermal nevus in a 42-year-old woman and provides no clinical findings beyond a biopsy showing hyperkeratosis and cellular pigmentary changes.
October 2024 in “Journal of the Endocrine Society” In this case report, researchers described a postmenopausal woman with virilization symptoms who was diagnosed with a Leydig cell tumor in her ovary, and symptoms improved following tumor removal. The authors highlighted the diagnostic challenge of differentiating such cases from age-related hormonal changes.
November 2023 in “Manuju” This paper discusses the complex relationship between polycystic ovary syndrome (PCOS) and hyperprolactinemia, noting a decrease in prolactin levels following bromocriptine treatment, but reports no new clinical findings.
November 2022 in “Journal of the Endocrine Society” This case report describes a 23-year-old woman with an adult granulosa cell tumor of the ovary, whose symptoms and hormone levels improved significantly after surgical removal of the tumor.
December 2021 in “Pathologica” This case report describes a rare instance of trichogerminoma with unusually numerous mitotic figures and a higher Ki67 proliferative rate, distinguishing it from previously documented cases.
January 2026 in “Annals of Pathology and Laboratory Medicine” In this case report, a 27-year-old woman with a swelling on her neck was initially misdiagnosed with squamous cell carcinoma, but was later identified as having pilomatrix carcinoma with lymph node metastasis, highlighting the importance of accurate diagnosis for effective treatment and prognosis improvement.
10 citations
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June 1999 in “Veterinary Dermatology” This report documents follicular dysplasia with pigmentary changes in two adult cows, contributing to the understanding of this rare condition in cattle.
January 2022 in “Clinical Cases in Dermatology” This article describes pilar cysts, common dermal cysts often seen in young women, which typically require surgical removal.
5 citations
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January 2018 in “Indian Dermatology Online Journal” This case report describes a strong dermoscopic and histopathological correlation in lichen nitidus, helping differentiate it from other similar conditions.
57 citations
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February 2006 in “Journal of Investigative Dermatology” Cylindromas likely originate from hair follicle stem cells, not sweat glands.
October 2025 in “Journal of the Endocrine Society” In this case study, a 62-year-old woman with ovarian hyperthecosis experienced normalization of elevated testosterone levels and improvement in hirsutism and hair loss following bilateral salpingo-oophorectomy.
August 2026 in “European Journal of Endocrinology” In this case report, researchers described how autoimmune thyroid disease can obscure primary hyperparathyroidism diagnosis, emphasizing the necessity of combining imaging, cytology, biochemical assessment, and parathyroid scintigraphy for accurate diagnosis.
May 2026 in “Annals of Internal Medicine Clinical Cases” This case report describes a postmenopausal woman with androgenic alopecia and progressive hirsutism who, despite normal imaging, had significantly elevated testosterone due to a Leydig cell tumor, revealed after surgical exploration; the condition improved post-surgery, underscoring the importance of considering such tumors in similar presentations.
October 2023 in “Journal of the Endocrine Society” This case report details a 73-year-old woman with significant hirsutism and hair loss linked to a rare ovarian Leydig cell tumor, which was resolved by bilateral salpingo-oophorectomy, normalizing her testosterone levels and addressing her symptoms.
7 citations
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October 2019 in “Case reports in endocrinology” This case report describes a woman with hyperandrogenism and menstrual disturbances, where an ovarian steroid cell tumor was identified and removed, leading to resolution of symptoms.
December 2024 in “AACE Clinical Case Reports” This study highlights a rare case of ovarian hyperthecosis in a 58-year-old postmenopausal woman, presenting with polycythemia and severe hyperandrogenism symptoms, with resolution of symptoms following laparoscopic bilateral oophorectomy.
April 2018 in “Journal of Investigative Dermatology” The study found that, unlike in actinic keratosis and squamous cell carcinoma, basal cell carcinoma tissues showed higher expression of nidogen1 and Col4 in both basement membranes and surrounding stroma compared to normal skin.
2 citations
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June 2019 in “The Journal of Dermatology” This report describes two cases of aplasia cutis congenita with hair collar signs and hemangioma, which may suggest neural tube defects, although imaging showed no bone or neural tissue abnormalities.
October 2024 in “Journal of the Endocrine Society” This clinical case study reports on a postmenopausal woman experiencing hair loss and virilization symptoms, which were ultimately attributed to rare ovarian tumors identified after a bilateral salpingo-oophorectomy, despite normal imaging results.
26 citations
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April 2007 in “Journal of clinical oncology” This case report describes the dermoscopic features of two cases of the tumor of the follicular infundibulum, contributing new insights as they had not been previously detailed in the literature.
September 2024 in “Medicine theory and practice” In a clinical case study, researchers identified adrenocortical adenoma as the cause of hyperandrogenism syndrome in a preschool-aged girl, following a comprehensive diagnostic process and successful surgical intervention to remove the tumor, leading to positive clinical improvements.