4 citations
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April 1983 in “The Journal of Dermatology” This case report describes a 15-year-old Japanese girl with juvenile hypothyroidism who developed hypertrichosis and hyperkeratosis due to a keratin plug inhibiting hair growth on her back and arms.
June 2026 in “Indian Dermatology Online Journal” In this case report, a 20-year-old man with a birthmark was identified as having a supernumerary nipple, a developmental anomaly, using dermoscopy to distinguish it from other pigmented skin lesions such as melanocytic nevus or basal cell carcinoma.
January 2002 in “Linchuang pifuke zazhi” This report describes an unusual case of proliferating trichilemmal cyst with trichoepitheliomatous change in a young woman, differing from its typical presentation in elderly women.
June 2023 in “Dermatopathology” In this case report, researchers described a unique skin lesion in a 55-year-old woman, identifying it as folliculosebaceous cystic hamartoma with an unusual combination of spindle cell lipomatous and neural components, which had not been previously documented in such cases.
March 2022 in “Folia Medica Indonesiana” This case report described a facial hairline tumor initially diagnosed as a sebaceous cyst but ultimately confirmed as a rare Proliferating Pilar Tumor with focal malignancies upon histopathological examination.
1 citations
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August 2023 in “Case Reports in Women s Health” This case study in a 62-year-old postmenopausal woman highlights Leydig cell hyperplasia as a likely cause of hyperandrogenism of ovarian origin, where bilateral oophorectomy resolved the condition and confirmed the diagnosis through histopathological examination.
February 2025 in “Clinical Chemistry” This case study reported a 34-year-old woman presenting with secondary amenorrhea, hirsutism, and obesity showed elevated testosterone and anti-Müllerian hormone levels, leading to the exclusion of nonclassical congenital adrenal hyperplasia as a diagnosis.
April 2026 in “BMJ Case Reports” This case study highlights the challenges of diagnosing hyperandrogenism in postmenopausal women, reporting a patient with androgenic alopecia and high testosterone due to a benign Leydig cell tumor in the ovary; surgery successfully normalized testosterone levels.
January 1996 in “대한피부과학회지” This study found a significantly higher density of Demodex mites in sebaceous hyperplasia lesions compared to controls, suggesting a possible link between Demodex and the development of these skin lesions.
May 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study describes a postmenopausal woman's diagnosis with ovarian hyperthecosis, confirmed by a GnRHa test normalizing testosterone, highlighting hormone therapy as a therapeutic option when surgery is not feasible.
April 2019 in “Journal of the Endocrine Society” In this case report, a 48-year-old woman's hyperandrogenism, presenting with symptoms like acne and hirsutism, was attributed to a benign Leydig cell tumor, which resolved after surgical removal.
October 2024 in “Journal of the Endocrine Society” In this case study, a postmenopausal woman with symptoms of virilization was diagnosed with a rare ovarian Leydig cell tumor, and surgical removal led to a resolution of her hyperandrogenism and related symptoms, highlighting the importance of thorough differential diagnosis in postmenopausal hyperandrogenism.
February 2021 in “Endocrinology, diabetes & metabolism case reports” This case report describes a postmenopausal woman with hirsutism and hair loss attributed to ovarian stromal hyperplasia; surgical removal of the ovaries normalized testosterone levels and resolved symptoms.
October 2024 in “Journal of the Endocrine Society” In this case report, a 66-year-old postmenopausal woman with hyperandrogenism and alopecia underwent bilateral salpingo-oophorectomy, which revealed rare synchronous ovarian tumors causing virilization, highlighting the importance of surgical exploration despite normal imaging.
October 2024 in “Journal of the Endocrine Society” This case report details a diagnostic challenge in a postmenopausal woman with severe hyperandrogenism where distinguishing between adrenal and ovarian causes was complicated by elevated 17-OH Progesterone and asymmetric ovarian enlargement; pending surgical pathology is expected to guide further management.
2 citations
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February 2009 in “Clinical and Experimental Dermatology” In this case study, a 51-year-old Japanese man was diagnosed with desmoplastic trichoepithelioma after histological examination of surgically excised facial plaques.
1 citations
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July 2015 in “AACE clinical case reports” This case report details a postmenopausal woman with hyperandrogenism due to both adrenal adenoma and ovarian hyperthecosis, highlighting the effectiveness of hormonal suppression and venous sampling for diagnosis.
March 2020 in “Endocrinology research and practice.” In this study, treating prolactinoma with cabergoline normalized prolactin levels and affected some androgen-related parameters, but did not significantly improve hirsutism in affected women.
May 2021 in “Journal of the Endocrine Society” This case report describes a 48-year-old woman with a history of PCOS and chemotherapy-induced menopause who was found to have a rare ovarian steroid cell tumor causing postmenopausal hyperandrogenism.
6 citations
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June 2006 in “International Journal of Gynecological Pathology” This study reports that in a case of benign Brenner tumor, elevated androgens may originate from luteinized stromal cells, as these cells do not convert androgen to estrogen due to suppressed aromatase biosynthesis.
December 2020 in “Research Square (Research Square)” This case series detailed three postmenopausal women with ovarian steroid cell tumors, highlighting that such tumors may present asymptomatically or with virilization, and found surgery effectively normalized androgen levels, with distinctive imaging features aiding diagnosis.
3 citations
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December 2003 in “Archives of Pathology & Laboratory Medicine” This article reviews the distinctive features of cutaneous lymphadenoma, a variant of trichoblastoma, and its differential diagnosis, but it presents no new empirical results.
1 citations
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February 2017 in “The American journal of dermatopathology/American journal of dermatopathology” This case report presented a 52-year-old man with cutaneous focal mucinosis, exhibiting rare follicular induction of the epidermis, underscoring the importance of recognizing this association in differential diagnoses.
9 citations
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January 2011 in “American Journal of Dermatopathology” This study investigated pilomatrixoma, a benign skin tumor, and found that irregular expression of β-catenin and Lef-1 in transitional cells may contribute to amorphous debris and cyst formation.
1 citations
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June 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that β-catenin stabilization in specific mammary epithelial lineages leads to cellular changes and the formation of hyperplastic lesions, revealing its role in initiating mammary neoplastic development.
October 2025 in “Journal of the Endocrine Society” This case study reported that sudden hyperandrogenism in postmenopausal women may indicate hormonally active ovarian tumors such as Leydig cell tumors, which can be effectively treated with surgery.
3 citations
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January 2021 in “touchREVIEWS in Endocrinology” This case report describes how a 68-year-old woman's hyperandrogenic symptoms improved and testosterone levels normalized after the surgical removal of an occult Leydig cell tumour.
19 citations
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July 1994 in “International Journal of Dermatology” This case report describes a 9-year-old Korean boy with a calcified nodule on his earlobe, confirmed by histopathologic examination and Von Kossa staining.
This report describes a complex case of postmenopausal hyperandrogenism with virilization and concurrent rare ovarian tumors, highlighting the critical role of interdisciplinary collaboration in diagnosing and managing such challenging scenarios.
9 citations
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April 2006 in “Experimental and Clinical Endocrinology & Diabetes” This article presents a case of primary adrenal localization of non-Hodgkin's lymphoma in a 70-year-old woman, detailing her diagnosis and treatment, with no signs of recurrent disease after polychemotherapy and radiotherapy.