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This study suggests that cerebrospinal fluid levels of the neurosteroids allopregnanolone and pregnanolone correlate negatively with PTSD and negative mood symptoms, with potential sex-specific differences in synthesis enzyme blocks.

This study found that the pharmacological inhibition of 5-α reductases with finasteride and dutasteride can reduce neurosteroid synthesis in glioblastoma-derived cell lines, potentially impacting GBM survival.

In this study, researchers found that in late pregnancy, the neuroactive progesterone metabolite allopregnanolone inhibits HPA axis responses to immune challenges via an opioid-mediated mechanism.

This study found that testosterone increased seizure severity in mice and rats, with its neurosteroid metabolites playing a role in modulating seizure susceptibility.

This study found that enhanced neurosteroid synthesis likely mediated by the translocator protein contributed to the anticonvulsant action of midazolam in mice.

Neonatal neurosteroid levels affect adult brain function and behavior.

This study identified significant changes in the expression of nine proteins in the nucleus accumbens of rats treated with finasteride, suggesting potential novel targets for its neuropsychiatric effects.

This study found that neonatal administration of allopregnanolone enhances, while finasteride suppresses, the effects of adult intrahippocampal pregnenolone sulphate on rat locomotor activity in an open field test.

Neurosteroids in the brain can increase or decrease seizure risk in mice.

This study found that midazolam, unlike clonazepam, increased neurosteroid levels and affected synaptic inhibition and plasticity in rat hippocampal neurons, suggesting unique actions via dual receptor activation.

In this study, ethanol was found to enhance GABAergic neurosteroid production and inhibit long-term potentiation in rat hippocampal slices via unblocked NMDA receptor activation, effects reversible by specific inhibitors.

This article investigates whether finasteride influences adult hippocampal neurogenesis related to depression and reports no new clinical findings; the authors suggest further research on its neurosteroid inhibition.

This study suggests that stress may worsen Tourette syndrome symptoms in mice by increasing allopregnanolone synthesis, with findings supporting finasteride as a potential treatment to manage symptom fluctuations.

This review examines the diverse roles of SRD5α enzymes across species, focusing on their involvement in steroid synthesis, sexual development, and various physiological processes, but reports no new clinical results.

In this study, clozapine reduced suicide-related behaviors in a schizophrenia-like mouse model, but its effects on exploratory behavior were counteracted by the neurosteroid inhibitor finasteride.

This study demonstrated that allopregnanolone administration caused significant scratching in atopic dermatitis mice, and ethanol-induced scratching may be linked to increased brain allopregnanolone levels.

This study found that diazepam had an exaggerated effect on GABA-related inhibitory tone in diabetic neuropathic mice compared to normal mice, potentially due to mitochondrial dysfunction affecting neurosteroid synthesis.

This study found that diazepam has an exaggerated effect on GABAergic inhibitory tone in diabetic neuropathy mouse models, likely due to upregulated neurosteroidogenic enzymes responding to mitochondrial dysfunction.

This study found that progesterone's antiseizure effects in mice occurred primarily through conversion to allopregnanolone, rather than through the progesterone receptor, as evidenced by results in PR knockout mice.

This review discusses the adverse effects of 5α-reductase inhibitors, finasteride and dutasteride, on sexual, psychological, and vascular health, emphasizing the need for physicians to inform patients of these risks.

This review discusses the presence of the StAR protein in 17 non-classical steroidogenic tissues, suggesting that advanced detection methods are needed for a complete understanding of its functions in these tissues.

In this study, 65% of men with persistent sexual side effects after stopping finasteride reported a reduction in alcohol consumption, echoing findings in rodent models.

This study demonstrates that locally synthesized estrogen and androgen neurosteroids play opposite roles in long-term synaptic changes in male rats' medial vestibular nucleus, with testosterone-dihydrotestosterone mediating long-term depression and 17β-estradiol mediating long-term potentiation.

In this study, researchers found that after reducing GABAergic inhibition in rats' auditory midbrain, the brain quickly compensates by increasing local neurosteroid synthesis to maintain balance in neural circuits.

This study found that finasteride impaired object recognition memory and altered hippocampal dendritic structures in male 3xTg-AD mice, suggesting potential sex differences in Alzheimer's disease pathology.

In this study, finasteride was found to potentiate stress-induced disruption in sensory gating of rats by neutralizing the increase in allopregnanolone levels after acute stress.

This review discusses the potential link between early postnatal allopregnanolone levels and vulnerability to drug abuse in adulthood, noting a need for more in-depth studies to confirm this relationship.

This study discusses the complex roles and effects of brain-synthesized sex neurosteroids, highlighting sex differences in their concentrations and their varied impacts on synaptic plasticity, cognitive behavior, and aging-related cognitive decline.

This study in neonatal rats found that inhibiting neurosteroid synthesis with finasteride unexpectedly reduced the severity and duration of neonatal seizures following birth asphyxia, maintained cognitive functions, but increased anxiety-like behaviors, highlighting a complex role of neurosteroids in hypoxic-ischemic encephalopathy outcomes.

This study found that neurosteroids influence oxytocin secretion in sheep, particularly during stress and pregnancy, suggesting their role in protecting and maintaining pregnancy under harmful conditions.