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This article reviews TNF-α inhibitor-induced alopecia, identifying various types of hair loss such as severe alopecia areata and scarring alopecia, and calls for more controlled studies to better understand this adverse effect.

This case report describes a 42-year-old woman with rheumatoid arthritis who developed extensive impetiginized pityriasis amiantacea potentially linked to her anti-TNF-α therapy with golimumab. Discontinuing the drug and other treatments led to significant clinical improvement within a month.

Some medications for inflammation can cause a condition with scalp rashes and hair loss, often linked to Crohn's disease, and may require treatment changes to prevent permanent hair loss.

In this case report, a 35-year-old man developed avascular necrosis after receiving intradermal corticosteroid injections for alopecia areata, marking the first documented instance of this side effect from such treatment.

In this case report, a 49-year-old heavy smoker experienced scalp necrosis after hair transplantation, but wound closure was achieved within two weeks using a treatment combining topical agents and photobiomodulation; the potential role of photobiomodulation needs further study.

This study reports a case of a 47-year-old man who developed scalp necrosis after undergoing hair transplantation abroad, highlighting the importance of recognizing and managing this rare but serious complication to improve outcomes in hair transplantation practices.

In this prospective study, 15 patients with patchy alopecia areata treated with intralesional methotrexate every two weeks showed a significant improvement in hair regrowth and reduction in lesion severity, with changes linked to decreased tissue levels of TNF-α.

This study found that patients with patchy alopecia areata had significantly higher serum levels of pro-inflammatory cytokines IL-6, TNF-α, IL-17A, and IL-21 compared to healthy controls, with these levels correlating positively with disease severity, age, and disease duration.

In this study, women with polycystic ovary syndrome showed significantly higher levels of DHEA, IL-6, and TNF-α compared to healthy controls, indicating a possible link between these biomarkers and PCOS.

This review suggests that immunomodulators, including TNF-α blockers and IL inhibitors, may improve symptoms of moderate-to-severe dissecting cellulitis of the scalp, but their effects on hair regrowth and scarring remain unclear.

In this case study, a patient developed parieto-temporal pain, tissue necrosis, and alopecia after receiving a hyaluronic acid injection for temporal augmentation, which was effectively treated with hyaluronidase and aspirin.

This review concluded that oral tofacitinib and adalimumab are promising treatments for cicatricial alopecia, showing effectiveness in improving signs and symptoms but requiring regular monitoring for adverse effects. The authors emphasize the need for further extensive studies to solidify these findings.

This study found that among over 10,000 hair transplantation patients, only four cases of scalp necrosis occurred, highlighting that timely diagnosis and treatment can prevent serious complications and improve outcomes, with most cases resolving within 2–3 weeks.

This study found that neutrophil-rich hair follicle inflammation caused by a monoclonal antibody targeting murine EGFR in mice involved TNFα and interleukin-1, suggesting these cytokines play a role in EGFR antibody-induced rashes in cancer patients.

This study in mice found that a monoclonal antibody targeting EGFR resulted in skin inflammation mediated by TNFα, suggesting potential pathways for addressing EGFR antibody-induced skin rash in cancer patients.

This study found that microneedling-induced microinjury in mice promoted hair growth by stimulating the TNF-α/Wnt/VEGF pathway, and blocking TNF-α inhibited this process.

This study observed that microneedling-induced microinjury promotes hair growth via a TNF-α, Wnt, and VEGF pathway, while blocking TNF-α inhibits this process.

This case report describes a 68-year-old patient with mild Sars-Cov2 infection who developed rapidly progressing bullous and necrotic skin lesions leading to osteomyelitis.

This study reports the case of a 12-year-old girl who developed psoriatic alopecia after increasing her dose of the TNF-α inhibitor adalimumab for Crohn's disease, emphasizing psoriatic alopecia as a phenomenon associated with these medications.

This article mentions an interesting case of a donor site from a previous issue, but reports no new research findings.

Some patients on anti-TNF drugs experience a type of hair loss called TAIAPA.

Some drugs for inflammation may cause psoriasis-like hair loss.

In this study, increased expression of TGF-β1 and TNF-α was observed in mice after lung irradiation, suggesting these cytokines play a role in radiation-induced pulmonary injury.

This letter argues that the lymphangitis reported from using cantharidin on warts is instead a case of aseptic necrosis common to other aggressive wart treatments.

This correspondence reports that using cantharidin on warts can result in lymphangitis, and dermatologists should consider all potential complications of treatments.

This study found that anti-TNF therapy-induced alopecia exhibits distinct clinical and histopathological features and can mimic psoriatic alopecia and alopecia areata, with some patients improving with topical treatment.

This study reports two cases of alopecia associated with anti-TNF therapy, highlighting a new entity combining features of alopecia areata and psoriatic alopecia.

This study reports that mesotherapy can lead to serious complications, such as multifocal scalp abscesses and subcutaneous fat necrosis, requiring extensive surgical repair.

This study analyzed RSN complications in 18 hair transplantation patients and found that smoking, diabetes, and hypertension may increase risk, highlighting the need for prevention strategies and timely treatment.