January 2018 in “Clinical dermatology open access journal” This review discusses the various applications of chitosan-based materials in dermatology and highlights their potential as promising new materials but does not present new experimental results.
January 2026 in “Preprints.org” This review highlights recent advancements in nanotechnology-based approaches for treating androgenetic alopecia, focusing on enhancing drug delivery to hair follicles, controlled release, and follicular microenvironment modulation, while addressing safety, manufacturing, and regulatory challenges for clinical application.
19 citations
,
July 2024 in “Drug Delivery” This review discusses how polymer-based nanocarriers can enhance drug delivery targeting hair follicles for acne treatment, focusing on factors affecting this delivery method, combination technologies to improve follicle targeting, and recent advancements in polymer nanodrug-delivery systems.
January 2018 in “Refubium (Universitätsbibliothek der Freien Universität Berlin)” In this study, researchers tested various nanocarrier characteristics and found they could enhance drug delivery to specific skin areas and immune cells, potentially improving treatments for skin conditions by targeting drugs effectively.
15 citations
,
August 2023 in “Journal of Nanobiotechnology” This review highlights recent advancements in using nanotechnology for scar prevention and treatment, emphasizing the unique properties of nanomaterials in drug delivery and the challenges that remain in maximizing their potential for effective scar interventions.
March 2026 in “ACS Applied Materials & Interfaces” This study described a novel three-dimensional-printed microneedle system designed for improved transdermal delivery of minoxidil to treat hair loss, demonstrating effective hair regrowth and safety in a mouse model while allowing sustainable needle base recovery.
26 citations
,
July 2023 in “International Journal of Nanomedicine” The researchers suggest that combining microneedle technology with nanocarriers could enhance drug delivery systems for treating central neurological diseases due to nanoparticles' ability to prolong blood circulation time and improve brain targeting.
365 citations
,
March 2021 in “Frontiers in Bioengineering and Biotechnology” This review discusses the potential of nanocarriers to enhance transdermal drug delivery and the combination of these carriers with physical methods, but it reports no new experimental results.
2 citations
,
March 2020 in “International Journal of Molecular Sciences” This article reviews advanced strategies for enhancing drug delivery to cutaneous stem cells to improve treatment for skin conditions and reports no new experimental findings.
January 2026 in “International Journal of Applied Pharmaceutics” This review discusses the integration of nanoparticles with microneedles to improve drug delivery through enhanced stability, bioavailability, and controlled release, noting ongoing challenges with stability, scalability, and safety.
32 citations
,
June 2024 in “Pharmaceutics” This review explores the use of topical and transdermal delivery for drugs and cosmetics, highlighting the benefits of avoiding side effects and rapid metabolism, with a focus on nanoparticulate formulations and techniques for studying skin penetration.
January 2015 in “SciDok (Saarland University and State Library)” This study confirmed the porcine ear skin model's effectiveness for studying nanoparticle-based drug delivery in human hair follicles, noting particle-dependent uptake and enhancement by massage.
7 citations
,
May 2023 in “Macromolecular Bioscience” This review discusses recent advancements in using macromolecules for hair loss treatment, highlighting microneedle and nanoparticle delivery systems, tissue-engineered scaffolds for hair follicle regeneration, and artificial skin platforms as drug screening methods.
5 citations
,
May 2025 in “Pharmaceutics” In this review, researchers evaluated sericin-based drug delivery systems for antimicrobial, anticancer, and neurodegenerative treatments, highlighting its potential benefits and challenges related to molecular variability and formulation stability, suggesting future focus on optimizing extraction and integration with advanced biomedical technologies.
July 2026 in “Journal of Drug Delivery and Therapeutics” This study evaluated Finasteride-loaded nanostructured lipid carriers for topical use in treating androgenetic alopecia and found that these carriers offer sustained drug release and may reduce systemic side effects compared to oral administration.
February 2026 in “Biomedicines” This review highlights advancements in nanotechnology-based treatments for androgenetic alopecia, noting that these strategies could improve targeting and modulation of hair follicle environments compared to traditional therapies like minoxidil and finasteride, but also emphasizes challenges around safety, manufacturing, and regulation.
This study observed that chitosan-decorated PS404-b-PAA63 nanoparticles may enhance skin retention and reduce permeation flux of finasteride, suggesting potential for improved transdermal delivery.
1 citations
,
December 2025 in “International Journal of Molecular Sciences” This review reports that chitosan-based systems with metal nanoparticles and polyphenols may enhance wound healing by improving the bioavailability and stability of these compounds, suggesting a potential new approach for chronic and diabetic wounds.
94 citations
,
September 2014 in “Therapeutic Delivery” This review describes recent advances in using nanoparticles for drug delivery to hair follicles, with potential applications in treating skin diseases such as alopecia and acne, but reports no new findings.
26 citations
,
December 2022 in “Molecules” This review discusses various nanotechnology-based strategies for managing melasma and reports no new clinical results, highlighting the potential of innovative drug delivery systems in treating hyperpigmentation.
November 2023 in “Materials Today Bio” In this study, researchers developed a novel temperature-sensitive biopolymer-based drug delivery system that enhanced the transdermal delivery of ISX9, a neurogenesis inducer, resulting in more effective hair follicle regrowth and signal pathway activation in vivo compared to traditional topical application.
July 2024 in “ACS Biomaterials Science & Engineering” In this study, researchers used a 3D in vitro organ culture system to show that rifampicin-loaded lipid nanocapsules can penetrate hair follicles more effectively than free rifampicin, highlighting the potential advantage of nanocarrier-based antibiotic treatments for follicular infections.
17 citations
,
June 2021 in “Molecules” This review summarizes the promising role of melatonin combined with nanosized carriers in drug delivery, suggesting enhanced effectiveness in treating various diseases compared to free melatonin.
This study developed a novel, 3D-printed dissolving microneedle system for delivering minoxidil to treat hair loss, which showed pH-triggered drug release and enhanced hair regrowth in an alopecia mouse model, offering a potentially sustainable and safe transdermal therapy option.
3 citations
,
October 2025 in “Journal of Materials Science Materials in Medicine” This review discusses various biomedical applications of hyaluronic acid, highlighting its roles in cancer treatment, wound healing, inflammation control, antibiotics, and antioxidant functions, with an emphasis on recent developments and potential for advanced drug delivery and tissue repair systems.
February 2026 in “Frontiers in Bioengineering and Biotechnology” This review discusses the development of liposome-based delivery systems to enhance skin wound healing, highlighting their advantages and potential applications, but reports no new clinical results.
39 citations
,
April 2011 in “Recent Patents on Drug Delivery & Formulation” This review discusses various applications of nanoemulsions in drug delivery and reports no new clinical results; it highlights the patents that cover these applications.
4 citations
,
January 2022 in “Current pharmaceutical design” This review discusses the benefits and applications of microsponges delivery systems in drug delivery, particularly for topical treatments, and reports no new clinical findings.
May 2023 in “Current Medicinal Chemistry” This review highlights the potential of microneedle devices in dermatology for conditions like skin aging and autoimmune skin diseases, emphasizing their ability to facilitate targeted drug delivery by creating temporary skin pathways.
April 2026 in “ACS Applied Materials & Interfaces” In this study, researchers developed a probiotic-based microneedle system combining Weissella cibaria and clascoterone to target androgenetic alopecia, which in a mouse model improved hair density, vascular regeneration, and reduced inflammation, suggesting a promising treatment approach.