28 citations
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June 1995 in “The Journal of Dermatology” This study reports that flaky skin mice exhibit skin and nail features that closely resemble human psoriasis vulgaris, suggesting they may serve as a natural model for this condition.
22 citations
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February 2012 in “Journal of Investigative Dermatology” A specific gene mutation causes severe skin and nail issues and hair loss.
11 citations
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August 1986 in “Archives of Dermatology” This case report describes a patient with skin and nail hyperpigmentation and premature gray hair due to vitamin B12 deficiency, which were reversed after treatment with cyanocobalamin.
2 citations
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November 1955 in “Archives of dermatology” In this report of a pediatric alopecia case, cortisone and ACTH gel treatments did not result in significant nail improvement, but there was considerable scalp hair regrowth.
June 2025 in “British Journal of Dermatology” In this case study, nail changes and skin lesions helped diagnose a 60-year-old man with advanced cardiac amyloidosis, highlighting the importance of considering amyloidosis in differential diagnoses for similar nail abnormalities and assessing for systemic involvement.
August 2024 in “Biomedical Journal of Scientific & Technical Research” This study assessed the use of a levered nail trimmer, finding that it may improve ease of nail trimming, enhance personal comfort, and potentially benefit general health and wellness, including reduced injury risk for bald individuals of all ages and backgrounds.
May 2018 in “European Journal of Dermatology” Adjusting the medication tacrolimus resolved a boy's red nail beds after a stem cell transplant.
January 2018 in “Springer eBooks” Terbinafine is the most effective medicine for fungal nail infections, especially for diabetics and those with weak immune systems.
March 2014 in “Journal of The American Academy of Dermatology” Terbinafine 250 mg is the most effective treatment for fungal nail infections.
February 2010 in “Journal of The American Academy of Dermatology” NB-002 is a promising new topical treatment for fungal nail infections, showing better results than a non-medicated option.
This study found that onychomatricoma can fully mimic the nail unit and differentiate toward the nail bed and isthmus, distinguishing it from other pilar tumors.
77 citations
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August 1986 in “Archives of Dermatology” This report describes a case in which intramuscular cyanocobalamin treatment reversed skin and nail pigmentation changes and premature gray hair caused by vitamin B12 deficiency due to pernicious anemia.
54 citations
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January 1995 in “Human Molecular Genetics” This study mapped monilethrix, a hereditary hair and nail disorder, to the type II keratin cluster on chromosome 12q, marking the first primary human hair disorder localization and implicating defects in "hard" keratins.
38 citations
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December 2006 in “Journal of Investigative Dermatology” Keratin patterns in hair follicles help understand hair growth and potential hair and nail disorders.
April 2023 in “Asian Medical Journal and Alternative Medicine” This study found that applying 2% topical minoxidil resulted in a greater nail growth rate compared to 5% minoxidil and placebo over eight weeks, with no observed side effects, suggesting 2% is an effective concentration for accelerating nail growth.
March 2016 in “Reactions Weekly” A woman experienced hair loss, nail changes, bone marrow suppression, and low blood protein after taking azathioprine.
July 2013 in “University of Southern California Digital Library” In this study, researchers identified slow cycling label retaining cells in nail and sweat gland appendages, showing stem cell characteristics similar to hair follicles but with distinct features.
February 2010 in “Journal of The American Academy of Dermatology” This study found that NB-002 demonstrated clear antifungal activity and clinically significant nail clearing in subjects with distal subungual onychomycosis and ≤50% nail involvement, compared to a vehicle treatment.
February 2010 in “Journal of The American Academy of Dermatology” This study found that the novel antifungal emulsion NB-002 demonstrated significant antifungal activity and nail clearing in patients with distal subungual onychomycosis involving ≤50% of the nail.
245 citations
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January 1998 in “Genes & Development” This study found that Hoxc13 mutations in mice cause defects in hair, nail, and tongue structures, with the most noticeable issue being brittle hair leading to alopecia.
62 citations
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October 1999 in “Journal of Investigative Dermatology” New mutations in hair keratin genes can change hair structure and cause monilethrix, with nail issues more common in certain gene mutations.
35 citations
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September 2004 in “American Journal of Dermatopathology” This case report introduces 'onycholemmal carcinoma' as a designation for a slowly growing malignant tumor of the nail bed epithelium in a 69-year-old male, with no recurrence or metastasis observed over four years after treatment.
10 citations
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July 2001 in “PubMed” This case report describes two patients with a likely new type of pachyonychia, characterized by nail thickening and severe generalized hypotrichosis, possibly linked to a mutation in a hard keratin.
8 citations
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September 2016 in “Journal of Investigative Dermatology” In this study, Flii overexpression in mice enhanced fingertip regeneration and nail formation after both distal and proximal amputations, suggesting a role in digit and hair follicle regeneration possibly involving Wnt signaling.
7 citations
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October 2016 in “American Journal of Dermatopathology” This report discusses a 77-year-old man with primary onycholemmal carcinoma, a rare nail bed tumor, emphasizing its slow growth, diagnostic challenges, and treatment typically involving surgical removal.
4 citations
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November 2019 in “Harper's Textbook of Pediatric Dermatology” This article reviews the skin, hair, nail, and mucosal changes linked to various pediatric endocrine disorders but provides no new clinical findings.
4 citations
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February 2011 in “Dermatology reports” In this study, oral acitretin therapy for psoriasis was associated with excess granulation tissue in the nail sulcus and noncicatricial universal alopecia.
1 citations
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June 2021 in “Case reports in gastrointestinal medicine” In this case study, a man's hair and nail symptoms, following dental treatments, resolved with mesalazine therapy after investigating suspected clindamycin allergy and diagnosing mucosal changes.
April 2025 in “Revista JRG de Estudos Acadêmicos” This study examined the use of Instagram® to share scientific information about onychomycosis, a common nail fungal infection, and found it to be an effective tool for engaging a broad audience with educational posts about prevention and treatment over two months.
In this case series, Xiang Chen reported instances of nail damage and hair loss following herpes zoster, noting the need for further exploration into the mechanisms and potential risk factors such as tuberculosis infection and kidney transplantation.