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Air pollution worsens skin diseases and aging by causing inflammation and oxidative stress.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Finasteride effectively treats BPH, but needs more trials to understand potential.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Taking selenium supplements during chemotherapy may help reduce side effects and improve health markers in ovarian cancer patients.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Finasteride exposure in pregnancy causes genital abnormalities in male rats.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.

Green tea may help with health issues like cancer, heart disease, and weight loss due to its high catechin content.

Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.

A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.

Certain mutations in the H6PD gene cause Cortisone Reductase Deficiency by affecting hormone production.

Norgestimate is the most effective birth control progestin for reducing an enzyme linked to acne and excessive hair growth in women.

The document concludes that accurate measurement of serum androgens is crucial for diagnosing hyperandrogenism.

Sophora flavescens extract may help hair grow by affecting growth factors and blocking a hair-related enzyme.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Some Thai plants, especially Carthamus tinctorius, could help prevent hair loss and promote hair growth without adverse effects.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

The triterpenoids from Ganoderma lucidum can block testosterone effects and may help treat enlarged prostate.