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    Glossary Multi-lineage differentiation

    ability of stem cells to become various specialized cells

    Multi-lineage differentiation refers to the ability of stem cells to develop into multiple types of specialized cells. For example, a single stem cell might differentiate into skin cells, muscle cells, or nerve cells, depending on the signals it receives. This process is crucial for tissue repair and regeneration, making it a key area of study in regenerative medicine and treatments for conditions like alopecia.

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    1. Multilineage-differentiating stress-enduring cells alleviate atopic dermatitis-associated behaviors in mice Stem Cell Research & Therapy · 2021 · 19 citations
    2. Equine adipose tissue derived stem cells and their multilineage differentiation Kocatepe Veterinary Journal · 2020
    3. LB1606 Retainability of pluripotency and viability of multilineage-differentiating stress enduring (Muse) cells after repeated cryopreservation. Journal of Investigative Dermatology · 2018 · 1 citations
    4. Cells Derived from Concentrated Growth Factor Exhibit a Multilineage Differentiation Capacity International Journal of Molecular Sciences · 2025 · 1 citations
    5. Intravital longitudinal wide-area imaging of dynamic bone marrow engraftment and multilineage differentiation through nuclear-cytoplasmic labeling PLoS ONE · 2017 · 17 citations
    6. Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties Nature cell biology · 2017 · 143 citations
    7. Multi-potentiality of a new immortalized epithelial stem cell line derived from human hair follicles In vitro cellular & developmental biology. Animal · 2008 · 34 citations
    8. Epidermal stem cell diversity and quiescence EMBO molecular medicine · 2009 · 168 citations
    9. Human skin stem cells and the ageing process Experimental gerontology · 2008 · 143 citations
    10. Participation of CD34-enriched mouse adipose cells in hair morphogenesis Molecular Medicine Reports · 2013 · 16 citations
    11. CD49fhigh Defines a Distinct Skin Mesenchymal Stem Cell Population Capable of Hair Follicle Epithelial Cell Maintenance 2019 · 11 citations
    12. Stem Cells in the Skin Springer eBooks · 2012
    13. Advanced Therapy Medicinal Products in Vitiligo; Current Status, Future Prospect, and Approved Treatments. PubMed · 2023 · 5 citations
    14. Plasticity of epithelial stem cells in tissue regeneration Science · 2014 · 479 citations
    15. Human Wharton’s Jelly Mesenchymal Stem Cells Plasticity Augments Scar-Free Skin Wound Healing with Hair Growth PloS one · 2014 · 102 citations
    16. Highly Pluripotent Adipose-Derived Stem Cell–Enriched Nanofat: A Novel Translational System in Stem Cell Therapy Cell Transplantation · 2023 · 28 citations
    17. Human Adipose-Derived Mesenchymal Stromal Cells Exhibit High HLA-DR Levels and Altered Cellular Characteristics under a Xeno-free and Serum-free Condition Stem Cell Reviews and Reports · 2021 · 12 citations
    18. Human Adipose-derived Mesenchymal Stromal Cells Exhibit High HLA-DR Levels and Altered Cellular Characteristics under a Xeno-free and Serum-free Condition Research Square (Research Square) · 2021
    19. Contribution of GFP Expressing Dermal Papillae Cells to the Formation of Chimeric Embryos and their Survival in Uterine Environment British Biotechnology Journal · 2016
    20. Single cell transcriptomics of human epidermis reveals basal stem cell transition states bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 5 citations
    21. Multipotent Nestin-Positive Stem Cells Reside in the Stroma of Human Eccrine and Apocrine Sweat Glands and Can Be Propagated Robustly In Vitro PloS one · 2013 · 33 citations
    22. Equine Hoof Stratum Internum K14+CD105+ Progenitor Cells: Culture, Characterization, and Model of Epithelial to Mesenchymal Transition 2019
    23. Therapeutic potential of stem cells in skin repair and regeneration Chinese Journal of Traumatology · 2008 · 73 citations
    24. Mesenchymal stem cells in periodontics: new perspectives RGO - Revista Gaúcha de Odontologia · 2017 · 1 citations
    25. Single-Cell Transcriptomics to Map Cellular Heterogeneity in Tissue Regeneration Models Drug Discovery and Molecular Docking (DDMD) · 2025
    26. The Autologous Hair Follicle and Its Secretome: A Multipotent Source for Cell-Based and Cell-Free Regenerative Therapies International Journal of Molecular Sciences · 2026
    27. A multi-omic single-cell landscape of perinatal mouse skin maps lineage specification and reveals shared dynamics in human fetal skin Experimental & Molecular Medicine · 2026
    28. Enhanced viability and neural differential potential in poor post-thaw hADSCs by agarose multi-well dishes and spheroid culture Human Cell · 2015 · 15 citations
    29. CircRNA-1926 Promotes the Differentiation of Goat SHF Stem Cells into Hair Follicle Lineage by miR-148a/b-3p/CDK19 Axis Animals · 2020 · 16 citations
    30. Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices Cell · 2017 · 214 citations