research New Insights Into Molecular Signaling Pathways And Current Advancements In Prostate Cancer Diagnostics And Therapeutics
New drugs and therapies targeting specific pathways show promise in treating advanced prostate cancer.
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research Attention Balanced Multi-Dimension Multi-Task Deep Learning for Alopecia Recognition
The new deep learning system can accurately recognize hair loss conditions with a 95.11% success rate.
research Epithelially Derived, Mitochondrial MPZL3 Negatively Regulates Murine and Human Hair Follicle Cycling
A protein called MPZL3 in mitochondria slows down hair growth and could be a target for treating hair growth disorders.
research Adverse Effect Profile With Low-Dose Methotrexate Therapy in Patients Suffering With Rheumatic Diseases
Low-dose methotrexate is generally safe but can cause mild to severe side effects, and folic acid can reduce these risks.
research Spontaneous Intrinsic Aging in Organ-Cultured Human Skin as a Novel Ex Vivo Assay to Test Anti-Aging Actives
The document concludes that a new method has been developed to test anti-aging substances on human skin, showing that these substances can reduce skin aging signs.
research The Bacterial Metabolite, Butyrate, Prolongs Anagen and Promotes Autophagy, Mitochondrial Activity, Melanogenesis and Antimicrobial Peptide Production in Human Scalp Hair Follicles
Butyrate helps hair grow longer, improves hair cell health, increases pigment production, and boosts hair's natural defenses.
research A Novel Link Between Human Hair Follicle Neuroimmunology and Mitochondrial Biology: Substance P Increases Intrafollicular Oxidative Stress and Mitochondrial Biogenesis
Substance P may contribute to hair loss by increasing oxidative stress and mitochondrial activity in hair follicles.
research CAQ Corner: Basic Concepts of Transplant Immunology
The document explains how the immune system reacts to organ transplants and the treatments used to prevent rejection.
research Effects of Essential Oil from Coicis Semen on Hair Growth in Human Dermal Papilla Cells
ECS may help treat hair loss by promoting hair cell growth.
research Protein Kinase C Downregulation Upon Rapamycin Treatment Attenuates Neuroinflammation and Mitochondrial Disease
Rapamycin treatment helps reduce brain inflammation and symptoms of mitochondrial disease by blocking specific pathways in mice.
research Calcineurin/Nuclear Factor of Activated T-Cell Pathway in Cutaneous Squamous Cell Carcinoma
The calcineurin/NFAT pathway plays a significant role in the development and growth of a type of skin cancer called cutaneous squamous cell carcinoma.
research A 2018 Approach to Combating Methotrexate Toxicity: Folic Acid and Beyond
New strategies like vitamin A and dextromethorphan can help reduce methotrexate side effects and improve patient adherence.
research Red Blood Cell Folate Level in Patients with Alopecia Areata
Red blood cell folate levels are reliable indicators of long-term folate status in alopecia areata patients.
research Would You Recognize This Lesion as a Gumma Syphilitica?
LED light helps hair follicle cells grow and prevents them from dying by activating certain cell pathways.
research Safety of Four Treatment Regimens in Early Rheumatoid Arthritis
All four treatments for early rheumatoid arthritis had similar safety profiles.
research Wnt/B-Catenin and ERK Pathway Activation: The Possible Mechanism of Various Light-Emitting Diode Light Regulates the Proliferation of Human Outer Root Sheath Cells
LED light helps human hair root cells grow and prevents them from dying by activating specific growth pathways.
research Influence of Bovine Milk Oligosaccharides on Sebocyte Lipid Content and Inflammatory Mediators
Cow milk sugars increase fat production and inflammation in skin oil cells.
research MicroRNAs in the Pathogenesis of Male Pattern Baldness
Different levels of microRNAs in different parts of the scalp can cause male pattern baldness.
research Methotrexate Treatment for Rheumatoid Arthritis in Poland: Retrospective Analysis of Patients in Routine Clinical Practice
Methotrexate is effective for treating rheumatoid arthritis but requires regular monitoring.
research Effects of High-Dose Daily Folate Versus Low-Dose Weekly Folate in Preventing Methotrexate Toxicity in Rheumatoid Arthritis Patients
Weekly 5 mg folate is enough to prevent methotrexate toxicity in rheumatoid arthritis patients.
research Study on the Cell Proliferation and Antioxidant Activity Effects of Different Extraction Methods of Salvia Miltiorrhiza Bunge and Scutellaria Baicalensis
Ethanol and ultrasonic wave extraction methods are best for making effective cosmetics and anti-hair loss products.
research Editors' Picks
Collagen VII helps skin heal and stay strong, sirolimus may lower skin cancer risk in kidney transplant patients, high-molecular-mass hyaluronan helps naked mole rats resist cancer, dermal γδ T cells aid in hair growth in rodents, and overexpression of IL-33 in mouse skin causes itchiness, offering a model for studying allergic inflammation treatments.
research Methotrexate Dose Has Minimal Effects on Methotrexate-Related Toxicity in Patients with Early Rheumatoid Arthritis Treated in Combination with Adalimumab – Results of Concerto Trial
Methotrexate dose has little effect on its toxicity when used with adalimumab for early rheumatoid arthritis.
research Trends in the Presence or Absence of Transaminitis and/or Leukopenia in Pediatric Patients Treated with Methotrexate for Inflammatory Skin Disease
Most children with skin inflammation taking methotrexate had lab abnormalities, but liver issues often improved without changing the medication dose.
research Effects of Ganoderma Lucidum Extract and Microneedle Therapy on Hair Growth in C57BL/6N Mice
Ganoderma lucidum extract and microneedle therapy promote hair growth in mice.
research Effects of Fructus Ligustri Lucidi Water Extract on Proliferation and Intracellular Signaling of Human Hair Dermal Papilla Cells
Fructus Ligustri Lucidi water extract helps hair growth by promoting cell survival and activating specific pathways.
research The Murine Hair Follicle Is a Melatonin Target
Melatonin directly affects mouse hair follicles and may influence hair growth.
research Comparative Study Between Topical Methotrexate 1% Gel and Minoxidil 5% Gel in the Treatment of Localized Alopecia Areata
Minoxidil showed better improvement than methotrexate in treating localized alopecia areata.
research A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men
New 5% minoxidil foam effectively promotes hair growth and is safe for use.
research Activation of Androgen Receptor Sensitizes Breast Carcinomas to NVP-BEZ235's Therapeutic Effect Mediated by PTEN and KLLN Upregulation
Breast cancer treatments work better with AR activation, improving results and reducing side effects.