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research 7288 A Preclinical Mouse Model of Gender-Affirming Hormone Therapy: Metabolic and Behavioral Outcomes
This study observed that gender-affirming hormone therapy differentially affects metabolism in mice, with the specific metabolic impacts dependent on the type of hormonal treatment used.
research Post-Exposure Syndromes as State-Space Trapping: A set-theoretic perspective on PSSD and the post-exposure family.
This study examines how conditions like PSSD, Long COVID, and ME/CFS form a "Post-Exposure Syndromes" family, initiated by transient exposures but persisting due to complex state-space dynamics, and suggests improving pharmacovigilance to better address and understand these persistent syndromes.
research Fixed-Drug Eruption due to Dextromethorphan
This case report details a fixed-drug eruption in a woman linked to the use of dextromethorphan, marking it as a previously unreported skin reaction to this medication.
research Experiences with Smo antagonist vismodegib for the treatment of locally advanced basal cell carcinoma
The study reported that vismodegib showed significant effectiveness in treating basal cell carcinoma, particularly in patients with Gorlin-Goltz syndrome or locally advanced BCC, but also highlighted substantial side effects, requiring careful management to prevent treatment resistance and maintain remission.
research SARGRAMOSTIN
This review discusses various herbal and pharmaceutical products, including their purported uses and possible interactions, but reports no new research findings.
research President's Message
This report on the 2019 Practice Census indicates growth in the global hair restoration surgical market.
research My First Terrible Diagnosis
This narrative recounts a medical student's early experiences of confidence in diagnostics, transforming into a commitment to honesty and empathy in patient care after a challenging clinical encounter.
research News and Notices
The document honored Yvonne, announced upcoming dermatology events, and introduced new journal editors.
research A Message From the President
This article previews the upcoming International Society of Hair Restoration Surgery meeting in Toronto, offering no new clinical results but promising more than typical technique presentations.
research ГНОТОБИОНТЫ – ЭКСПЕРИМЕНТАЛЬНАЯ МОДЕЛЬ
In this study, the authors observed that controlled microflora in gnotobionts leads to delayed maturation of T-dependent lymphocytes in the thymus, affecting cellular immunity reactions.
research Editorial: Software survey section
research The selective androgen receptor modulator GTx‐024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double‐blind, placebo‐controlled phase II trial
This study found that GTx-024 significantly increased total lean body mass and improved physical function in healthy elderly men and postmenopausal women, suggesting potential use for muscle wasting conditions.
research Certificate of Appreciation Award Letter to Professor Jasna Lipozen?i?
research Disproportionality analysis comparing safety profiles of sonidegib and vismodegib based on the FAERS database
This study reports that hedgehog pathway inhibitors, sonidegib and vismodegib, showed distinct adverse event patterns in real-world data, suggesting the need for further research to confirm these findings.
research Case Report: A Chinese Family of Woodhouse-Sakati Syndrome With Diabetes Mellitus, With a Novel Biallelic Deletion Mutation of the DCAF17 Gene
In this study, a novel DCAF17 gene mutation was identified in a Chinese family, suggesting a potential role in pancreatic β cell dysfunction and diabetes development in Woodhouse-Sakati syndrome.
research Notices
This abstract describes the structure and offerings of microsurgical workshops hosted at the Plastic Surgery Unit at Canniesburn Hospital, providing no new research findings.
research Post-Exposure Syndromes as State-Space Trapping: A set-theoretic perspective on PSSD and the post-exposure family.
This presentation argues that post-exposure syndromes like PSSD and Long COVID form a coherent group of conditions driven by complex interactions in high-dimensional state spaces rather than singular molecular pathways.
research Bilateral conjunctival lesions in Melkersson-Rosenthal syndrome
This article discusses the potential of intralesional cidofovir for treating SCC without systemic toxicity, noting that surgical excision remains the best treatment option; it reports no new clinical results.
research Notes from the Editor Emeritus, 1999–2001: The Buyer’s Remorse Dilemma
This article discusses a case of a patient with Norwood 3 balding who was treated with finasteride and temporal thickening via strip FUT; it reports no new results.
research Classified Advertising
This abstract contains no research findings; it outlines website features and access options for the JAMA network's publications.
research Guest Co-Editors’ Messages
This article offers a conversational update on the field of hair restoration but reports no new research findings.
research Whiskers amiss, a new vibrissae and hair mutation near the Krt1 cluster on mouse Chromosome 11
This study identified a new mutation in SELH/Bc mice causing distinctive whisker and body hair abnormalities, mapped near the type I keratin cluster on chromosome 11.
research A blistering child: sudden erythema with blisters in a sick girl
This study identified a novel splice-site variant of the LAMB3 gene that may cause junctional epidermolysis bullosa, suggesting gene sequencing is essential for accurate diagnosis.
research Helminth TGF-β mimic, TGM, increases leukocyte migration and activation while also enhancing cutaneous wound healing and tissue regeneration.
In this study, a TGF-β mimic molecule from Heligmosomoides polygyrus was observed to enhance wound healing in mice, with improved tissue regeneration and specific immune cell recruitment without increased scarring.
research Novel de novo pathogenic variant in the ODC1 gene in a girl with developmental delay, alopecia, and dysmorphic features
This case report describes a 32-month-old girl with a newly identified pediatric disorder linked to a de novo mutation in the ODC1 gene, mirroring symptoms seen in a transgenic mouse model.
research Gut Microbiota Is Different Between Gender Affirming Hormone Therapy Compared To Gender Affirming Surgery
In this rodent study, the researchers found that different hormone therapies affected gut microbiota and goblet cell counts, with notable microbial shifts observed between groups receiving estrogen with and without an orchiectomy, linked to estrogen metabolism.
research Introduction
research Black Hairy Tongue After Allogeneic Stem Cell Transplantation: An Unrecognized Cutaneous Presentation of Graft-Versus-Host Disease
This study reported that black hairy tongue can occur after allogeneic stem cell transplantation and may indicate cutaneous graft-versus-host disease, highlighting the need for histopathologic evaluation.
research Balint’s syndrome—missed or mistaken?
The document concludes that early diagnosis of Balint's syndrome is crucial for effective treatment and that understanding drug interactions, like between ritonavir and statins, is important for patient care.