104 citations
,
December 2004 in “Journal of Neurochemistry” This study found that androgens, specifically DHT, induced neurite outgrowth in motor neurons by up-regulating the neuritin protein, with testosterone being less effective.
7 citations
,
September 2013 in “Tissue engineering. Part A” This study suggests that nestin-expressing hair follicle stem cells, when transplanted into transgenic mice with sciatic nerve injury, can differentiate into motor neurons and reduce muscle atrophy.
48 citations
,
June 2014 in “Neurobiology of Disease” This study found that stem cells derived from spinal and bulbar muscular atrophy patients exhibited reduced androgen receptor levels and HDAC6, providing potential insights into the disease mechanism for future therapies.
6 citations
,
February 2022 in “The journal of neuroscience/The Journal of neuroscience” This study observed that deleting PTEN in mouse facial motoneurons enhanced peripheral axon regeneration but also led to physiological changes and potential hyperplasia in older mice.
241 citations
,
January 2001 in “Reviews on Environmental Health” This review discusses the various adverse health effects of chronic selenium exposure in humans, including effects on endocrine and immune function, and suggests current exposure limits may be insufficient.
February 2020 in “Journal of chemical neuroanatomy” This study suggests that five small molecules can induce hair follicle neural crest stem cells to differentiate toward motor neuron progenitor cells with a unipotent differentiation potential.
2 citations
,
July 2016 in “Pharmacopsychiatry” This case report describes a non-mosaic Turner-Syndrome individual with global cerebral atrophy, significant cognitive impairment, and severe treatment-resistant schizophrenia.
This article provides no abstract or new findings and focuses on a patient registry related to spasticity care.
8 citations
,
January 2024 in “Medical Principles and Practice” This study found that silencing IGFBP5 reduced neurotoxicity and motor deficits in the 6-OHDA model of Parkinson's disease, likely by affecting the SHH signaling pathway, suggesting its potential role in mitigating Parkinson’s-related neuronal damage.
2 citations
,
September 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study demonstrated that ablation of individual somatostatin-expressing interneurons increased activity in nearby neurons of the mouse motor cortex during motor learning.
14 citations
,
October 2018 in “Brain Research Bulletin” This article reviews the role of exosomes in promoting axonal regeneration and discusses recent findings on how exosome-borne molecules might influence the PTEN-mTOR pathway in injured neurons; it reports no new experimental results.
1 citations
,
January 2015 in “Der pharmacia lettre” This study found that neurosteroids might play a role in the neuroprotective effects of ischemic postconditioning by reducing brain infarct size and improving motor performance and memory in mice.
36 citations
,
July 2019 in “Journal of Materials Science Materials in Medicine” This study demonstrated that keratin derived from human hair can improve axon extension and alleviate motor deficits from sciatic nerve injuries, highlighting its potential as a promising biomaterial for peripheral nerve regeneration.
December 2025 in “International Journal of Molecular Sciences” This study found that an aqueous extract of Bacopa procumbens improved motor function and preserved neuronal structure in a mouse model of Parkinson's disease, suggesting its neuroprotective potential.
This study found that exosomes derived from hair follicle neural crest stem cells significantly promoted nerve regeneration in injured neurons, particularly when overexpressing miR-214-3p, which enhanced axon extension and motor function recovery in both in vitro and in vivo models.
January 2024 in “Turkish Neurosurgery” Dexpanthenol helps protect the brain and improve motor skills after a stroke.
March 2014 in “Human Physiology” This study found that prolonged administration of DHEA improved long-term memory and brain activity balance in old rhesus macaques, with effects like increased motor activity and restored hair lasting a year.
10 citations
,
August 2024 in “Neuroscience & Biobehavioral Reviews” This review discusses the role of neuro(active)steroids, particularly those in the 5α reductase pathway, in modulating dopamine signaling and their impact on neuropsychiatric disorders characterized by dopamine imbalances, including addiction, schizophrenia, and Parkinson's Disease.
1 citations
,
September 2025 in “Viruses” This study of HCPS survivors in Chile found that 61.9% reported incomplete recovery at 3-6 months post-symptom onset, with ECMO users experiencing more motor dysfunction and palpitations, highlighting the need for multidisciplinary care to address persistent symptoms.
October 2020 in “Stem cells” This study highlights a novel connection between the DNMT3B enzyme, metabolic flux, and the self-renewal and differentiation of human embryonic stem cells.
28 citations
,
November 2009 in “European Journal of Neuroscience” This study found that progesterone can increase glycine release in rat brainstem neurons through its conversion to allopregnanolone, which modulates presynaptic GABA receptor activity.
42 citations
,
May 2013 in “Oral Diseases” Kennedy's disease leads to muscle weakness without a cure, but exercise and managing symptoms may help patients live a normal lifespan.
1 citations
,
August 2025 in “Frontiers in Neuroscience” This review discusses cellular senescence in relation to ALS and explores how targeting senescent cells could potentially serve as a treatment strategy, but it reports no new clinical findings and emphasizes that this link is not yet conclusively established.
34 citations
,
November 1991 in “Choice Reviews Online” This work reviews the structure and functions of the nervous system, covering topics from nerve cell properties to the mechanisms of learning and memory, but does not present new research findings.
25 citations
,
June 2017 in “Molecular and Cellular Endocrinology” This review discusses the negative effects of anabolic androgenic steroids on various organ systems in men and reports no new results, highlighting the need for physician awareness.
12 citations
,
February 1986 in “PubMed” This study found that newborn mice given 6-aminonicotinamide developed skin, intestinal, and central nervous system lesions, offering insights into the mechanisms of pellagra.
298 citations
,
January 2014 in “BioMed Research International” This review discusses various methods for obtaining stem cell-derived conditioned media and its applications in disease treatment, finding generally positive results but highlighting the need for standardized production methods.
4 citations
,
January 2025 in “Translational Psychiatry” In this study, remote photobiomodulation therapy to the lungs improved behavioral and neurological outcomes in rats with repeated closed-head injuries, suggesting potential preventive benefits for brain health.
February 2024 in “Neurophotonics” This review highlights the potential of transcranial photobiomodulation (tPBM) as a non-invasive and affordable treatment for brain diseases, summarizing recent advances and successful protocols based on over two decades of research.
25 citations
,
December 2009 in “Developmental Neurobiology” In this study, the authors concluded that androgens, but not estrogens, strictly mediate the maintenance of neuromuscular morphology in the spinal nucleus of the bulbocavernosus in adult rats.