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The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.

Corticosteroids, especially prednisone, improve short-term muscle strength in Duchenne muscular dystrophy but have manageable side effects.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

About 2.2% of women with symptoms of high male hormones have a mild form of congenital adrenal hyperplasia, and measuring a specific hormone level can accurately diagnose it.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

Hair loss linked to higher heart disease risk in both men and women.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

Certain mutations in the H6PD gene cause Cortisone Reductase Deficiency by affecting hormone production.

Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.

Taking low-dose spironolactone and metformin together works better for PCOS symptoms than either drug alone.

Most dermatologic medications are safe during pregnancy and breastfeeding, but some should be avoided due to potential risks.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

People with polycystic ovary syndrome have a higher chance of having chronic thyroiditis.

The document suggests treating individuals with nonclassic congenital adrenal hyperplasia who show symptoms, especially those related to excess male hormones.

Some skin conditions may indicate metabolic syndrome, which could help with early detection and management of related health issues.

Most patients with hard-to-treat high blood pressure can be managed effectively with various treatments, but no single treatment is perfect.

Eating healthy, exercising, and taking certain supplements can help manage Polycystic Ovary Syndrome symptoms.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

The document suggests creating a validated score to diagnose Cushing's Syndrome and considers plasma steroid profiling as a simpler diagnostic method.

Excessive hair growth can be assessed by history, exam, and blood tests, and treated with medication like dexamethasone, birth control pills, and spironolactone.

Hidradenitis suppurativa may be related to hormones and patients often have metabolic disorders; more research is needed to understand this connection.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.