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This review outlines recent advancements in understanding how micro-RNAs (miRNAs) influence hair regeneration, highlighting their role in stimulating hair growth and potential therapeutic approaches, while also addressing the challenges of clinical translation due to miRNAs' complex roles and delivery issues.

In this study, researchers identified the miR-22-3p/CLIC4 signaling pathway as a key regulator in hair follicle miniaturization among androgenetic alopecia models, suggesting that targeting CLIC4-mediated sonic hedgehog pathway disruption may offer new therapeutic strategies for AGA treatment.

This study identified a unique circulating microRNA signature associated with severe alopecia areata, distinguishing it from other inflammatory skin conditions and suggesting these miRNAs as non-invasive biomarkers for diagnosis and potential therapeutic targets.

This study found that overexpression of miR-1246 in peripheral CD4+ T cells can reduce markers associated with inflammation and T cell activation in severe active alopecia areata, suggesting potential therapeutic benefits.

This study found that arctiin, a compound from Arctium lappa, demonstrated protective effects against oxidative stress-induced dysfunction in human hair dermal papilla cells, suggesting potential therapeutic use for alopecia.

In this integrative study, the researchers examined microRNA-mRNA networks related to androgenetic alopecia and found that miR-146b-5p may promote hair growth and improve inflammation, highlighting a potential therapeutic target for the condition.

This review discusses various applications of CRISPR-based tools in cancer research, emphasizing their potential for investigating microRNA functions and developing microRNA-based therapies, despite challenges like off-target effects and delivery issues in using CRISPR/Cas9.

In liver cancer cells, this study found that upregulating hsa_circ_0002980 inhibits cell proliferation, metastasis, and EMT by modulating the miR-1303/CADM2 axis, suggesting it as a potential therapeutic target.

MicroRNA-21 could help diagnose and treat skin fibrosis.

This study discovered that exosomes from adipose-derived mesenchymal stem cells can mitigate damage in dermal papilla cells by modulating the TGF-β1/SMAD2 signaling pathway through miRNAs miR-574-3p and miR-125a-5p, revealing potential therapeutic targets for androgenetic alopecia.

This review discusses the potential of exosomes as a therapy for hair loss and the need for better regulation and understanding of their molecular effects, but reports no new clinical results.

This review summarizes the role of non-coding RNAs in hair follicle regeneration and highlights potential therapeutic strategies, though it reports no new experimental results.

This review discusses the role of Toll-like receptors in wound healing and highlights their potential therapeutic value but notes that their role in human wound healing and chronic wounds is not well understood.

This study found that miR-486 and miR-451 levels were reduced in alopecia areata-affected skin, and delivering their mimics to mice mitigated symptoms by reducing inflammation and immune activity.

This review discusses the expanded understanding of WNT10B's role in various tissues and diseases over the past decade, emphasizing its genetic correlations and potential therapeutic implications, but reports no new clinical results.

This study found that nanovesicles derived from ReNcell VM cells promoted hair growth in mice by activating the Wnt/β-catenin signaling pathway, suggesting they may serve as an alternative to extracellular vesicles for hair growth therapy.

In this study, hair follicle neural crest stem cell-derived exosomes, especially those overexpressing miR-214-3p, significantly promoted axon extension and nerve regeneration in both in vitro and in vivo models, suggesting a promising therapeutic strategy for peripheral nerve injuries.

This study found that increasing the levels of specific microRNAs from the miR-17∼92 cluster improved wound healing in mice by reducing inflammation, suggesting a potential therapeutic approach for chronic wounds.

This article reviews the role of microRNAs as epigenetic modulators in dermatology but reports no new clinical findings.

This review summarizes the current understanding of microRNAs in skin biology, highlighting their roles in processes like wound-healing and aging, without presenting any new experimental results.

This study found that exosomes from different mesenchymal stem cell sources had distinct effects on immune cell functions and varied microRNA expression profiles compared to their original cells.

In this study, transcriptome analysis identified 68 differentially expressed miRNAs in human dermal papilla cells treated with hydrogen peroxide, suggesting they play a significant role in growth arrest and apoptosis.

This study found that miR-148a plays a significant role in regulating skin homeostasis and hair follicle cycling, influencing stem cell activity and development in mice.

This review highlights the critical role of microRNAs in regulating hair follicle biology, significantly impacting wool and cashmere development by modulating gene expression and signaling pathways in sheep and goats.

The researchers reported that miR-21 expression increases with age in both human and mouse skin and may contribute to skin aging by targeting the chromatin remodeler SATB1 in keratinocytes.

This study found that hair follicle stem cells are stiff with high actomyosin contractility, while hair germ progenitors are soft and enlarge during quiescence, influencing hair regeneration; inducing miR-205 reduces contractility and activates regeneration in mice.

In this study, researchers found that Dicer, but not Tarbp2, plays a crucial role in regulating the growth phase of hair follicles in post-natal mice.

This study demonstrates that the transcription factor DLX5 can promote hair follicle stem cell differentiation through regulating the c-MYC/miR-29c-3p/NSD1 axis.

This review found that gut microbiota and exosomal microRNAs may collectively impact androgenetic alopecia progression by modulating immune responses and intercellular communication, suggesting new therapeutic possibilities; however, further research is needed to clarify these mechanisms.

This study systematically reviews the Wnt/β-catenin signaling pathway, discussing its origin, composition, function, involvement in tumors and diseases, and the development of small-molecular compounds targeting this pathway for disease treatment.