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This study aimed to develop a new transdermal patch for treating androgenetic alopecia using finasteride, combined with chemical permeation enhancers to improve drug delivery through the skin, but results of pharmacokinetics and pharmacodynamics evaluations are not reported.

This review discusses the applications and potential of microneedles loaded with extracellular vesicles for tissue regenerative repair and disease diagnosis, but does not report new experimental findings.

This review examines hydrogel microneedles for transdermal drug delivery, discussing their applications and challenges but reports no new clinical results.

A new microneedle system may improve hair loss treatment by delivering ketoconazole directly to hair follicles.

This study developed and tested Bicalutamide-loaded lipid vesicles in dissolving microarray patches for topical application, finding that they effectively deliver Bicalutamide through murine skin while maintaining a favorable safety profile, suggesting potential to improve treatments for androgenetic alopecia.

This study found that microneedles containing magnetic intracellular vesicles and tremella polysaccharide improved the hair microenvironment and accelerated hair regeneration in mice with androgenic alopecia.

In this study, researchers found that dissolving microneedles made with hyaluronic acid enhanced the effectiveness of minoxidil in reducing hair loss and promoting hair growth in alopecia-affected mice more effectively than topical minoxidil alone, while using only 10% of the drug amount.

Hydrogel microneedles with special nanoparticles and growth factor improve hair growth better than minoxidil for hair loss treatment.

This study developed a microneedle system using black phosphorus nanosheets and baicalin for treating androgenetic alopecia, finding it effectively enhanced drug penetration and follicular targeting while showing synergistic efficacy and safety in preclinical tests, including in vivo model efficacy against testosterone-induced hair loss.

This study found that smaller curcumin nanocrystals (60 nm) enhanced transdermal and transfollicular penetration more effectively than larger sizes, influenced by particle size.

Dissolvable microneedles are a promising, painless method for effective skin treatments.

This review discusses the safety and potential adverse events of microneedling as both a medical and consumer product, noting the need for further understanding; no new clinical results are presented.

This review discusses transdermal drug delivery using hydrogel-forming microneedles and highlights their potential for disease treatment, but notes challenges in their clinical application.

This review highlights the potential of microneedles and nanomedicine in advancing tissue regeneration, emphasizing their innovative, localized, and minimally invasive approaches as promising solutions to current challenges in treating chronic wounds and degenerative diseases.

In this study, researchers developed grooved microneedles made from hyaluronic acid for precise transdermal drug delivery, achieving accurate dosage with a high probability of delivery (98% or more) by using an easy-to-operate applicator for shearing force.

New microneedle method improves hair regrowth treatment delivery.

This study found that a dissolvable microneedle device delivering rapamycin and epigallocatechin gallate nanoparticles significantly enhanced hair regrowth in C57BL/6 mice within 7 days, demonstrating increased hair shaft growth and follicle density with minimal inflammation compared to untreated mice.

The researchers suggest that combining microneedle technology with nanocarriers could enhance drug delivery systems for treating central neurological diseases due to nanoparticles' ability to prolong blood circulation time and improve brain targeting.

This study found that cubosomes combined with dissolving microneedles enhanced transdermal penetration and hair growth efficacy of beta-sitosterol for treating alopecia.

In animal studies, this research found that minoxidil-loaded air-pocket microneedles improved hair loss treatment efficiency compared to topical application, while effectively sealing punctured skin openings.

This study observed that dissolving microneedles made from PVP-K90 and HPMC E50, incorporating Oryza sativa L. extract complex, showed enhanced transfollicular skin penetration and maintained safety for keratinocytes, with the P25H5 formulation demonstrating faster dissolution and greater effectiveness.

This study found that a microneedle system delivering VEGF and Ritlecitinib improved hair regeneration in mice with androgenetic alopecia, showing faster anagen onset and better hair quality compared to minoxidil.

This review highlights that while nanoparticle-loaded dissolving microneedles have considerable promise for enhancing transdermal drug delivery, progress is delayed by insufficient understanding of their in vivo behavior, which the authors emphasize as crucial for advancing clinical applications.

This study found that Dex-loaded hyaluronic acid hydrogel microneedles significantly reduced pain in an acute inflammatory visceral pain model without sedation, suggesting a promising and patient-friendly alternative to intravenous delivery.

This study found that combining microneedling with 5% Minoxidil and Finasteride significantly improved hair density and hair shaft diameter in males with androgenetic alopecia, outperforming Minoxidil alone or in combination with Finasteride, although changes in hormonal levels and trace elements were not significant.

In this study, researchers developed microparticle-embedded gas-propelled microneedles that showed higher drug loading and transdermal delivery efficiency compared to traditional microneedles.

This review highlights the transformative potential of bioinspired polymers in biomedical engineering, focusing on their roles in enhancing tissue engineering, regenerative medicine, and other biomedical applications, with innovations including mimicking the extracellular matrix, self-healing, antibacterial properties, and cancer therapy.

This review highlights recent advances in personalized transdermal drug delivery systems, noting their potential for improved treatment efficacy and safety, but identifies significant challenges in clinical translation.

This review discusses the potential of nanocarriers to enhance transdermal drug delivery and the combination of these carriers with physical methods, but it reports no new experimental results.