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This article reviews advanced strategies for enhancing drug delivery to cutaneous stem cells to improve treatment for skin conditions and reports no new experimental findings.

In this review, researchers discussed various novel drug delivery systems, including lipid nanocarriers and polymeric nanoparticles, that may enhance treatment for alopecia by improving drug localization in hair follicles and reducing systemic exposure, potentially offering better outcomes than conventional treatments.

PLGA-based microneedles show promise for painless, long-term drug delivery but need design and safety improvements.

This review discusses the potential of microneedles in cancer diagnosis and treatment, highlighting advances and ongoing clinical trials, but reports no new results; it emphasizes the minimally invasive nature of this technology.

This review discusses the evolution and development of smart and multifunctional microneedles, highlighting their potential future importance in medical applications, but it reports no new experimental results.

This review article highlights recent advances in microneedle technology for wound healing and tissue regeneration, discussing various cargo types, structural designs, and fabrication methods, and suggesting guidelines for designing microneedle systems tailored to specific applications.

This review highlights recent advancements in microneedle technology, noting its ability to enhance transdermal drug delivery, biosensing, cancer treatment, and skin disease repair, while emphasizing its potential for improving patient compliance and reducing side effects.

This study demonstrated that while the proposed placebo microneedle stamp design was partially successful in blinding participants with low skin sensitivity, further development of suitable placebo controls is needed.

This review discusses the design, properties, and potential applications of smart microneedles, with no new clinical results presented.

This review summarizes the use of 3D printing technologies for creating microneedles and evaluates their associated benefits, challenges, and regulatory considerations, but does not present new experimental results.

This article provides an overview of microneedle technology for transcutaneous drug delivery, discussing microneedle designs, materials, and activation methods that enhance drug stability and regulated release, and outlines considerations for their successful clinical implementation, such as biocompatibility and production cost.

This systematic review examines the landscape of cosmetic microneedling using SWOT analysis, identifying strengths like precise delivery and self-administration, while noting challenges such as potential skin damage and regulatory issues, with opportunities in AI-enhanced targeted treatments noted by these researchers.

This review highlights the potential of microneedles as a pediatric-friendly method for delivering proteins, vaccines, and diagnostics transdermally, noting their ability to penetrate the skin's barrier and suggesting future applications in other parts of the body.

In this review, recent advances in long-acting microneedle-based transdermal drug delivery systems are outlined, highlighting biodegradable polymers like PLA, PLGA, and PCL for sustained release and discussing challenges in clinical translation such as consistency in manufacturing and validating long-term efficacy and safety.

This review discusses recent advancements in microneedle technology for hair loss treatment, highlighting their ability to enhance drug delivery and improve hair follicle survival in transplantation, while also exploring their potential integration with tissue engineering to address regeneration challenges.

This review highlights the application of microneedle technology as a promising advancement in psoriasis management, focusing on its roles in enhanced transdermal drug delivery and minimally invasive biomarker monitoring, while also discussing current challenges and future research directions.

This study explores the use of bioinspired 3D printed hollow microneedles, which may offer improved delivery of anti-wrinkle formulations, and reviews the current landscape and challenges of existing wrinkle treatments and microneedle technology.

This study developed a hydrogel microneedle system combining ginseng-derived exosomes and biomimetic nanoparticles to address oxidative stress, inflammation, and melanocyte deficiency in vitiligo, showing significant repigmentation in mice within 3 weeks by enhancing melanocyte protection and keratinocyte proliferation.

This review highlights the potential of microneedle technology in traditional Chinese medicine as a promising transdermal delivery system for skin diseases, showcasing improved efficacy and reduced side effects of TCM ingredients while discussing the challenges of its clinical application.

This study found that microneedle delivery of Polygonum multiflorum extract led to earlier pigmentation and hair regrowth in mice with androgenetic alopecia.

This study found that platelet-rich plasma microneedles promoted hair regrowth in mice by facilitating angiogenesis and cell proliferation, showing promise for a minimally invasive hair regeneration treatment.

This review explores how microneedles can improve the delivery of dermatological treatments by bypassing the skin's outer barrier, discussing their potential use in managing skin diseases, cosmetic applications, and challenges related to clinical adoption.

This review discusses hydrogel-forming microneedles for non-invasive drug delivery in dermatology and reports no new clinical results, emphasizing their promise in improving treatment adherence and patient comfort.

This review focuses on recent advances in smart responsive polymer microneedles, which offer precise, on-demand drug delivery triggered by external or physiological stimuli, highlighting significant research implications for transdermal drug administration according to this source.

This review discusses the challenges of traditional phytochemical delivery methods and highlights the potential of microneedles to improve intra/transdermal delivery, reporting no new clinical results.

This review highlights the potential of microneedles for immunotherapy, emphasizing their ability to enhance immune responses and reduce side effects through precise and stimuli-responsive delivery, especially in tumor treatment, while also noting the limitations and areas for improvement in current systems.

This review discusses transdermal drug delivery using hydrogel-forming microneedles and highlights their potential and challenges for clinical application, but it reports no new clinical findings.

This article reviews recent developments in microneedles combining metallic elements and herbal compounds for wound healing, highlighting their benefits such as enhanced therapeutic efficacy and reduced toxicity, and offering a reference for future advancements in this technology.

This review summarizes recent research on microneedles for alopecia treatment and hair regrowth, noting their potential to improve drug delivery and patient outcomes, but reports no new clinical results.

This study highlights the clinical potential of microneedles as an innovative transdermal drug delivery system for treating various skin diseases with minimal pain and high patient compliance.