This study found that increasing methionine in the diet of pregnant rabbits may stimulate the development of hair follicles and improve hair fiber diameter in their offspring.
January 2011 in “Reactions Weekly” Long-term use of minoxidil may cause hair follicles to transform into noticeable terminal hairs, leading to trichostasis spinulosa.
March 2010 in “The Journal of Urology” This study demonstrated that methylation of the 5-alpha reductase type 2 (5-AR2) promoter is linked to reduced expression of the 5-AR2 protein, possibly explaining resistance to Finasteride in some BPH patients.
February 2010 in “Journal of The American Academy of Dermatology” This study found that nonobese women with idiopathic hirsutism had significantly lower nitrite/nitrate concentrations and higher fibrinogen levels compared to controls, but similar levels to women with PCOS.
October 2007 in “Obstetrical & Gynecological Survey” The researchers reported that low-dose methotrexate, in combination with surgical dilatation and local treatments, may improve symptoms in patients with severe stenosing vulvovaginal lichen planus.
October 2006 in “Eclética Química” This study presents three spectrophotometric methods for determining finasteride in bulk and tablet forms, showing a linear relationship between absorbance and finasteride concentration.
January 2005 in “Jukuri (Natural Resources Institute Finland (Luke))” This study found that lower dietary protein with supplemented methionine allowed blue foxes to grow normally and produce high-quality pelts while reducing feed costs and environmental phosphorus and nitrogen loads.
January 2002 in “Chinese Journal of Pharmaceuticals” This study reports the preparation of a key intermediate for finasteride and epristeride with a 69% overall yield from pregnenolone acetate.
February 2023 in “Journal of Aesthetic Nursing” This source reviewed various methods for hair restoration in men and women, emphasizing clinical approaches and treatment options but did not report specific outcomes.
January 2022 in “Wiadomości lekarskie (Warsaw Poland)” This study found that Methylsulfonylmethane significantly reduced hair loss and enhanced hair growth and follicle number in male mice, attributed to its antioxidant and anti-inflammatory properties.
January 2022 in “Clinical, Cosmetic and Investigational Dermatology” This study reports promising results for alopecia universalis treatment using a combination of systemic methotrexate and low-dose corticosteroids with topical minoxidil, though monitoring for side effects is necessary.
July 2020 in “European urology open science” Methylated gene parts may cause finasteride-resistance in some enlarged prostate patients.
February 2019 in “PubMed” This study found that women with androgenetic alopecia were prescribed more topical treatments like minoxidil compared to men, who were more often given systemic therapies.
March 2016 in “European Urology Supplements” This study identified that methylation of the 5-AR2 gene promoter is linked to reduced expression of 5-AR2 protein, which may explain why some BPH patients are resistant to finasteride treatment.
667 citations
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May 2008 in “Genes & Development” This review discusses the biochemical and biological functions of histone demethylases and their potential involvement in human diseases, including cancer, but reports no new findings.
305 citations
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July 2016 in “International Journal of Biological Macromolecules” This review describes the roles of polysaccharides in antitumor, antiviral, and anti-inflammatory activities and introduces methods for their isolation and purification, reporting no new research results.
166 citations
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August 2010 in “Proceedings of the National Academy of Sciences of the United States of America” This study reports a less invasive method for detecting human clock gene expression using hair follicle cells, which accurately reflects individual behavioral rhythms and suggests a time lag issue for rotating shift workers.
138 citations
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April 2003 in “Carcinogenesis” This study found that 2-methoxyestradiol induces apoptosis in human prostate cancer cells by activating p53 through a pathway dependent on p38/JNK-mediated NFkappaB/AP-1 activation, with JNK-dependent Bcl-2 phosphorylation also playing a critical role.
91 citations
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January 2009 in “International Journal of Trichology” This review discusses the advantages and limitations of various hair loss evaluation methods but reports no new results; it emphasizes the importance of cautious interpretation for these diagnostic tools.
88 citations
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January 1981 in “British Journal of Dermatology” This study describes a new method for culturing human hair follicle cells, achieving 70% successful growth of keratinocyte colonies using a bovine eye lens capsule substrate.
75 citations
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June 2007 in “Journal of Biological Chemistry” This study found that the combination of MT-DADMe-ImmA and MTA selectively induced apoptosis in head and neck squamous cell carcinoma cell lines FaDu and Cal27, but not in normal fibroblasts or MTAP-deficient breast cancer cells.
74 citations
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January 2020 in “Frontiers in Genetics” In this study, the researchers identified key genes with differential m6A methylation involved in cashmere fiber growth, suggesting these modifications may play a significant role in this process.
72 citations
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July 2012 in “Journal of Investigative Dermatology” This study found that mice with a specific loss of DNA methyltransferase 1 showed uneven epidermal thickness, reduced hair regeneration, and progressive alopecia, emphasizing DNA methylation's role in stem cell homeostasis.
67 citations
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January 1987 in “The Journal of urology/The journal of urology” New hormonal therapies can help treat advanced prostate cancer but may cause testicular issues.
57 citations
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January 2019 in “Stem Cell Research & Therapy” OCT4 helps hair stem cells renew and fight aging, potentially aiding hair regrowth.
45 citations
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May 1992 in “Journal of Investigative Dermatology” 43 citations
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July 2005 in “Journal of Chromatography B” This study developed a sensitive method to precisely determine hair lipid composition, demonstrating specific lipid changes from the root to the tip in untreated hair fibers from two women.
39 citations
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August 2022 in “Cell Death and Disease” This study found that a dopamine-methacrylated hyaluronic acid hydrogel enhances the efficacy of adipose-derived stem cells in promoting skin regeneration, potentially involving the Notch signaling pathway.
39 citations
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January 2020 in “Frontiers in Genetics” This study found that stage-specific epigenetic changes, particularly involving the gene PDGFC, may affect wool fiber development in Zhongwei goats, potentially serving as a biomarker for fur goat selection.
35 citations
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November 2021 in “Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology” This study identified dynamic changes in DNA methylation associated with different growth stages in Tan sheep, which may offer insights to retain their valuable curly fleece as they age.