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    Glossary Matrix Metalloproteinases

    enzymes that degrade extracellular matrix proteins

    Matrix Metalloproteinases (MMPs) are a group of enzymes that break down proteins in the extracellular matrix, which is the network of molecules surrounding cells. They play a crucial role in tissue remodeling, wound healing, and various physiological processes, but their overactivity can contribute to diseases like arthritis and cancer.

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    1. Matrix Metalloproteinase-19 Expression in Normal and Diseased Skin: Dysregulation by Epidermal Proliferation Journal of Investigative Dermatology · 2003 · 56 citations
    2. Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases in the hair cycle Experimental and Therapeutic Medicine · 2016 · 21 citations
    3. Matrix Metalloproteinase-9 Is Involved in the Regulation of Hair Canal Formation 2010 · 20 citations
    4. Human Scalp Dermal Papilla and Fibrous Sheath Cells have a different expression profile of Matrix Metalloproteinases in vitro when compared to Scalp Dermal Fibroblasts Archives of Dermatological Research · 2005 · 9 citations
    5. A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the presence of polycystic ovary syndrome in Caucasian women Fertility and Sterility · 2005 · 8 citations
    6. Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2 Journal of Neuroinflammation · 2018 · 22 citations
    7. In-Vitro Anticancer Activity of Chemical Constituents from Etlingera alba Poulsen against Triple Negative Breast Cancer and in silico Approaches towards Matrix metalloproteinase-1 Inhibition Indonesian Journal of Science and Technology · 2022 · 7 citations
    8. Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate International Journal of Molecular Sciences · 2018 · 57 citations
    9. Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling Frontiers in bioengineering and biotechnology · 2022 · 8 citations
    10. Oral Centella asiatica Extract Attenuates UVB-Induced Skin Photoaging via Antioxidant, Anti-Inflammatory, and Extracellular Matrix-Preserving Effects in Hairless Mice International Journal of Molecular Sciences · 2025
    11. Human Fibroblast‐Derived Matrix Hydrogel Accelerates Regenerative Wound Remodeling Through the Interactions with Macrophages Advanced science · 2024
    12. Wound Healing: A Cellular Perspective Physiological Reviews · 2018 · 1160 citations
    13. Cellular and molecular mechanisms of repair in acute and chronic wound healing British Journal of Dermatology · 2015 · 908 citations
    14. Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection Cell Host & Microbe · 2016 · 133 citations
    15. The Pathobiology of Skin Aging American Journal Of Pathology · 2020 · 122 citations
    16. Thymosin β<sub>4</sub>increases hair growth by activation of hair follicle stem cells The FASEB Journal · 2003 · 98 citations
    17. Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells Proceedings of the National Academy of Sciences of the United States of America · 2017 · 92 citations
    18. Scarless wound healing: Transitioning from fetal research to regenerative healing Wiley Interdisciplinary Reviews-Developmental Biology · 2018 · 79 citations
    19. Skin connective tissue and ageing Best Practice & Research in Clinical Obstetrics & Gynaecology · 2013 · 77 citations
    20. Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne 2009 · 65 citations
    21. Comparison of two ASC-derived therapeutics in an in vitro OA model: secretome versus extracellular vesicles Stem Cell Research & Therapy · 2020 · 60 citations
    22. Evaluation of hydro-alcoholic extract of Eclipta alba for its anticancer potential: An in vitro study Journal of Ethnopharmacology · 2011 · 50 citations
    23. Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin. The Absence of Type VII Collagen is Associated with Gelatinase-A (MMP2) Activity Journal of Investigative Dermatology · 2000 · 42 citations
    24. 17β-Estradiol Inhibits Wound Healing in Male Mice via Estrogen Receptor-α American Journal Of Pathology · 2010 · 38 citations
    25. Mammalian Fetal Organ Regeneration 2005 · 32 citations
    26. Identification of clustered cells in human hair follicle responsible for MMP‐9 gelatinolytic activity: consequences for the regulation of hair growth International Journal of Dermatology · 2001 · 27 citations
    27. Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF-1, and&nbsp;TGF-&beta; expression Drug Design Development and Therapy · 2015 · 27 citations
    28. Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia Journal of The American Academy of Dermatology · 2018 · 25 citations
    29. Effects of non-ablative fractional erbium glass laser treatment on gene regulation in human three-dimensional skin models Lasers in Medical Science · 2016 · 24 citations
    30. Identifying key components and therapeutic targets of the immune system in hidradenitis suppurativa with an emphasis on neutrophils 2020 · 16 citations