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    Did you mean Matrix Metalloproteinase-1?
    Glossary Matrix Metalloproteinase-1

    enzyme that breaks down collagen in connective tissues

    Matrix Metalloproteinase-1 (MMP-1), also known as interstitial collagenase, is an enzyme that breaks down collagen, a key structural protein in the skin and other connective tissues. This process is crucial for normal tissue remodeling and repair, but excessive MMP-1 activity can contribute to conditions like skin aging and certain diseases by degrading too much collagen.

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    1. Matrix Metalloproteinase-19 Expression in Normal and Diseased Skin: Dysregulation by Epidermal Proliferation Journal of Investigative Dermatology · 2003 · 56 citations
    2. Inhibition of TNF-α-Induced Collagen Degradation and Oxidative Damage by Centipeda minima and Brevilin A in Human Dermal Fibroblasts Current Issues in Molecular Biology · 2025 · 1 citations
    3. Anti-aging effect of <i>Grateloupia elata</i> extract in skin Journal of Applied Biological Chemistry · 2025
    4. Antioxidant Capacity and Protective Effect of Cow Placenta Extract on D-Galactose-Induced Skin Aging in Mice Nutrients · 2022 · 4 citations
    5. In Vivo Evaluation of<i>Eclipta alba</i>Extract as Anticancer and Multidrug Resistance Reversal Agent Nutrition and Cancer · 2014 · 9 citations
    6. Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate International Journal of Molecular Sciences · 2018 · 57 citations
    7. Age-Related Changes in Female Scalp Dermal Sheath and Dermal Fibroblasts: How the Hair Follicle Environment Impacts Hair Aging Journal of Investigative Dermatology · 2020 · 14 citations
    8. Facial pore refining by targeting dermal and epidermal functions: Assessment across age and gender Journal of Cosmetic Dermatology · 2024 · 6 citations
    9. Air Pollution, Autophagy, and Skin Aging: Impact of Particulate Matter (PM10) on Human Dermal Fibroblasts International Journal of Molecular Sciences · 2018 · 68 citations
    10. Identifying key components and therapeutic targets of the immune system in hidradenitis suppurativa with an emphasis on neutrophils 2020 · 16 citations
    11. Radiofrequency Currents Modulate Inflammatory Processes in Keratinocytes International Journal of Molecular Sciences · 2024 · 3 citations
    12. An <i>eGFP-Col4a2</i> mouse model reveals basement membrane dynamics underlying hair follicle morphogenesis The Journal of Cell Biology · 2024
    13. MON-203 Dermatological Effects Of Hormone Replacement Therapy Journal of the Endocrine Society · 2025
    14. Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne 2009 · 65 citations
    15. New treatments for rheumatoid arthritis Postgraduate Medicine · 1999 · 13 citations
    16. Senotherapeutic Potential of Araliadiol in Senescent Human Dermal Fibroblasts: An In Vitro Study Using Three Senescence Models Pharmaceutics · 2025
    17. Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases in the hair cycle Experimental and Therapeutic Medicine · 2016 · 21 citations
    18. Matrix Metalloproteinase-9 Is Involved in the Regulation of Hair Canal Formation 2010 · 20 citations
    19. Human Scalp Dermal Papilla and Fibrous Sheath Cells have a different expression profile of Matrix Metalloproteinases in vitro when compared to Scalp Dermal Fibroblasts Archives of Dermatological Research · 2005 · 9 citations
    20. A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the presence of polycystic ovary syndrome in Caucasian women Fertility and Sterility · 2005 · 8 citations
    21. In-Vitro Anticancer Activity of Chemical Constituents from Etlingera alba Poulsen against Triple Negative Breast Cancer and in silico Approaches towards Matrix metalloproteinase-1 Inhibition Indonesian Journal of Science and Technology · 2022 · 7 citations
    22. Effects of autologous platelet‑rich plasma injections on facial skin rejuvenation Experimental and Therapeutic Medicine · 2020 · 40 citations
    23. Defining stem cell dynamics and migration during wound healing in mouse skin epidermis Nature Communications · 2017 · 363 citations
    24. Cthrc1 deficiency aggravates wound healing and promotes cardiac rupture after myocardial infarction via non-canonical WNT5A signaling pathway International Journal of Biological Sciences · 2023 · 9 citations
    25. Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection Cell Host & Microbe · 2016 · 133 citations
    26. Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells Proceedings of the National Academy of Sciences of the United States of America · 2017 · 92 citations
    27. Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia Journal of The American Academy of Dermatology · 2018 · 25 citations
    28. Oral Centella asiatica Extract Attenuates UVB-Induced Skin Photoaging via Antioxidant, Anti-Inflammatory, and Extracellular Matrix-Preserving Effects in Hairless Mice International Journal of Molecular Sciences · 2025
    29. Human Fibroblast‐Derived Matrix Hydrogel Accelerates Regenerative Wound Remodeling Through the Interactions with Macrophages Advanced science · 2024
    30. Evaluation of hydro-alcoholic extract of Eclipta alba for its anticancer potential: An in vitro study Journal of Ethnopharmacology · 2011 · 50 citations