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    Glossary Matrix Metalloproteinase-1

    enzyme that breaks down collagen in connective tissues

    Matrix Metalloproteinase-1 (MMP-1), also known as interstitial collagenase, is an enzyme that breaks down collagen, a key structural protein in the skin and other connective tissues. This process is crucial for normal tissue remodeling and repair, but excessive MMP-1 activity can contribute to conditions like skin aging and certain diseases by degrading too much collagen.

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    1. Matrix Metalloproteinase-19 Expression in Normal and Diseased Skin: Dysregulation by Epidermal Proliferation Journal of Investigative Dermatology · 2003 · 56 citations
    2. A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the presence of polycystic ovary syndrome in Caucasian women Fertility and Sterility · 2005 · 8 citations
    3. Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases in the hair cycle Experimental and Therapeutic Medicine · 2016 · 21 citations
    4. Matrix Metalloproteinase-9 Is Involved in the Regulation of Hair Canal Formation 2010 · 20 citations
    5. Human Scalp Dermal Papilla and Fibrous Sheath Cells have a different expression profile of Matrix Metalloproteinases in vitro when compared to Scalp Dermal Fibroblasts Archives of Dermatological Research · 2005 · 9 citations
    6. Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2 Journal of Neuroinflammation · 2018 · 22 citations
    7. In-Vitro Anticancer Activity of Chemical Constituents from Etlingera alba Poulsen against Triple Negative Breast Cancer and in silico Approaches towards Matrix metalloproteinase-1 Inhibition Indonesian Journal of Science and Technology · 2022 · 7 citations
    8. Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1 Frontiers in Cell and Developmental Biology · 2020 · 3 citations
    9. Oral Centella asiatica Extract Attenuates UVB-Induced Skin Photoaging via Antioxidant, Anti-Inflammatory, and Extracellular Matrix-Preserving Effects in Hairless Mice International Journal of Molecular Sciences · 2025
    10. 1396 Interferon-24 regulates the expression of MMP1 and dermal collagen of the skin Journal of Investigative Dermatology · 2023
    11. 17β-Estradiol Inhibits Wound Healing in Male Mice via Estrogen Receptor-α American Journal Of Pathology · 2010 · 38 citations
    12. Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF-1, and TGF-β expression Drug Design Development and Therapy · 2015 · 27 citations
    13. Human Fibroblast‐Derived Matrix Hydrogel Accelerates Regenerative Wound Remodeling Through the Interactions with Macrophages Advanced science · 2024
    14. 13. Wound Healing & Hair Journal of Cutaneous Medicine and Surgery · 2003
    15. Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling Frontiers in bioengineering and biotechnology · 2022 · 8 citations
    16. Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate International Journal of Molecular Sciences · 2018 · 57 citations
    17. Referee report. For: Molecular mediators involved in skin healing: a narrative review [version 1; peer review: 1 approved with reservations] Faculty of 1000 Research Ltd · 2022
    18. Effects of autologous platelet‑rich plasma injections on facial skin rejuvenation Experimental and Therapeutic Medicine · 2020 · 40 citations
    19. Expression Profiling and Cellular Localization of Genes Associated with the Hair Cycle Induced by Wax Depilation 2005 · 27 citations
    20. Age-Related Changes in Female Scalp Dermal Sheath and Dermal Fibroblasts: How the Hair Follicle Environment Impacts Hair Aging Journal of Investigative Dermatology · 2020 · 14 citations
    21. Modulation of Photoaging-Induced Cutaneous Elastin: Evaluation of Gene and Protein Expression of Markers Related to Elastogenesis Under Different Photoexposure Conditions Dermatology and Therapy · 2021 · 14 citations
    22. Commentary on Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth Dermatologic Surgery · 2012 · 13 citations
    23. Effects of ginsenoside Rb1 on hypertrophic scar remodeling in rabbit model European journal of pharmacology · 2015 · 10 citations
    24. Connective tissue sheath of hair follicle is a major source of dermal type I procollagen in human scalp Journal of dermatological science · 2012 · 4 citations
    25. Antioxidant Capacity and Protective Effect of Cow Placenta Extract on D-Galactose-Induced Skin Aging in Mice Nutrients · 2022 · 4 citations
    26. Inhibition of TNF-α-Induced Collagen Degradation and Oxidative Damage by Centipeda minima and Brevilin A in Human Dermal Fibroblasts Current Issues in Molecular Biology · 2025 · 1 citations
    27. MON-203 Dermatological Effects Of Hormone Replacement Therapy Journal of the Endocrine Society · 2025
    28. Matrisomal components involved in regenerative wound healing in axolotl and <i>Acomys</i>: implications for biomaterial development Biomaterials Science · 2023
    29. The effects of infrared radiation on the human skin Photodermatology, Photoimmunology and Photomedicine · 2023
    30. Anti-aging effect of <i>Grateloupia elata</i> extract in skin Journal of Applied Biological Chemistry · 2025