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The safety and effectiveness of gender-affirming treatments for children are uncertain, with potential long-term risks like infertility.

Acne can be managed with various treatments and requires psychological support due to its emotional impact.

Postmenopausal ovary stromal cells have a unique makeup and limited steroid production, suggesting androgens come from the adrenal gland.

Rare ULBP3 gene changes may raise the risk of Alopecia areata, a certain FAS gene deletion could cause a dysfunctional protein in an immune disorder, and having one copy of a specific genetic deletion is okay, but two copies cause sickle cell disease.

A complex X chromosome rearrangement can increase the risk of multiple autoimmune diseases.

Acitretin is effective for severe skin conditions but has significant side effects and requires careful monitoring.

Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.

Acyzol could help treat conditions caused by zinc deficiency.

Some skin, hair, and nail supplements can be toxic, interact with medications, affect lab tests, and may increase cancer risk.

Biomimetic scaffolds are better than traditional methods for growing cells and could help regenerate various tissues.

The document discusses how to diagnose and treat conditions like acne, excessive hair growth, and female pattern hair loss related to hormone imbalances.

A 15-year-old girl has a skin condition causing blisters on her feet, likely inherited from her family.

Low doses of BPA can increase prostate growth and change hormone levels in adult rats.

Some skin diseases and their treatments can negatively affect male fertility.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Monascus helps prevent baldness, prostate issues, and may be a natural alternative to medications.

Urologic diseases and treatments in older men can negatively affect fertility, and doctors should talk to patients about this.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

PFS and PSSD are similar conditions with persistent sexual dysfunction after stopping medication.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Most drugs fail to reach the market, but understanding their properties and using strategies like early toxicity tests and drug repurposing can help advance their development.

The mouse model suggests male pattern baldness may be due to an enzyme increasing DHT and higher androgen receptor levels in hair follicles.

Doctors should know how to diagnose and treat PCOS, which often involves checking for high male hormone levels and using medications to manage symptoms.

Wearing headcovers doesn't affect male-pattern hair loss severity.

Excess androgens may cause PCOS, not just be a symptom.

The document concludes that identifying the cause of amenorrhea is crucial for proper treatment.

Amenorrhea is when a woman doesn't have periods, with primary amenorrhea starting by age 15 or within five years of breast development, and secondary amenorrhea when periods stop for three months. It affects 3-4% of women not pregnant, breastfeeding, or in menopause, mainly due to polycystic ovary syndrome, hypothalamic amenorrhea, hyperprolactinemia, and ovarian failure.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.