October 2025 in “Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)” This study details that worldwide about 2% of the population identified as transgender in 2024 and highlights significant mental health improvements with gender-affirming medical interventions, such as decreased depression and gender dysphoria, and enhanced quality of life.
April 2025 in “European Journal of Pharmaceutics and Biopharmaceutics” This study developed and tested Bicalutamide-loaded lipid vesicles in dissolving microarray patches for topical application, finding that they effectively deliver Bicalutamide through murine skin while maintaining a favorable safety profile, suggesting potential to improve treatments for androgenetic alopecia.
September 2024 in “Open Repository of the University of Porto (University of Porto)”
This review describes deep eutectic solvents as a green alternative to toxic solvents in extracting bioactive compounds, highlighting their sustainability, production from natural ingredients, and beneficial properties for pharmaceutical applications.
October 2023 in “Biomaterials” This review highlights the potential of nanotechnology for hair follicle regeneration, focusing on strategies such as hair cycle modulation, progenitor cell stimulation, and wound-induced hair neogenesis, while also discussing regulatory challenges that may affect the development of these innovative approaches.
103 citations
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March 2015 in “Nature Communications” This study identified a genetic locus associated with idiopathic scoliosis in females, which might influence spinal gene expression and was previously linked to protection from early-onset alopecia.
65 citations
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September 2014 in “BMC genomics” This research found that variations in the KRTAP gene family are likely responsible for the diverse hair phenotypes seen among mammals, influenced by gene repertoire differences, expression, and evolutionary factors.
12 citations
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July 2020 in “Actas Dermo-Sifiliográficas” This study found that facial papules and rosacea in patients with frontal fibrosing alopecia were linked to a greater need for oral treatment, with most cases involving postmenopausal women.
4 citations
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May 2019 in “Biology open” This study found that while testosterone administration reduced myocardial damage in gonadectomized rats after ischemia/reperfusion injury, Finasteride led to greater improvements, whereas 4-hydroxyandrostenedione worsened outcomes.
April 2026 in “Research Square” This study found that COVID-19 infection disrupts spermatogenesis, alters testicular cell populations, and may impact male fertility by causing long-term changes in testicular function and reduced sperm quality, as observed even in patients who have recovered from the acute phase of the infection.
December 2022 in “Indian Journal of Endocrinology and Metabolism” This study found that six months of combined estrogen-progestin pill therapy led to a significant reduction in serum AMH levels and improvement in hyperandrogenic symptoms among women with PCOS.
May 2021 in “Boletín latinoamericano y del Caribe de plantas medicinales y aromáticas” This study found that ethanolic extracts of Microsechium helleri showed notable antioxidant, hypoglycemic, and cardioprotective activities, while chloroformic extracts exhibited significant anti-inflammatory effects in experimental models.
January 2019 in “Revista Dermatológica Centro Uraga” This review discusses congenital temporal triangular alopecia, focusing on its clinical presentation and dermatoscopic diagnosis, and highlights the limited understanding of its etiology and treatment options; it reports no new clinical results.
60 citations
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August 2008 in “Human molecular genetics online/Human molecular genetics” This study suggests that a position effect disrupting TRPS1 expression may be linked to hypertrichosis in both Ambras syndrome in humans and a similar phenotype in Koa mice.
29 citations
,
March 2022 in “Biomedicines” This review discusses recent findings on cellular antioxidant responses to oxidative stress and their implications for treating various human diseases but reports no new clinical results.
26 citations
,
January 2017 in “Journal of Clinical Pediatric Dentistry” This study observed that dental erosion was common among adolescents in Pasto, Colombia, with dietary habits like frequent juice consumption and snacking on artificially flavored lemon products linked to increased risk.
12 citations
,
January 2021 in “Journal of Cutaneous and Aesthetic Surgery” This systematic review describes current findings on the use of recombinant epidermal growth factor (rhEGF) for skin aging and wound healing, emphasizing its potential benefits but highlighting the need for more controlled studies to optimize dosing and treatment protocols.
7 citations
,
August 2023 in “Dermatologic Surgery” In this study, researchers reported that a new skin-responsive FU excision device consistently succeeded in all patients of African descent, showing a mean graft transection rate of less than 10%, with skin thickness and firmness identified as major factors affecting graft attrition rate.
3 citations
,
September 2010 in “Acta Médica Portuguesa” This review explores the psychosocial impact of PCOS symptoms on health-related quality of life, emphasizing the need for multidisciplinary care and individual perspectives, but reports no new research findings.
1 citations
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July 2017 in “Skin appendage disorders” A 9-year-old Hispanic girl has Uncombable Hair Syndrome, which may improve with age and biotin treatment.
1 citations
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April 2010 in “DOAJ (DOAJ: Directory of Open Access Journals)” This review discusses the psychosocial impact of polycystic ovary syndrome on women's quality of life and highlights the need for multidisciplinary care, but it reports no new clinical results.
March 2025 in “OncoTargets and Therapy” This study found that in circulating tumor cells from non-invasive liquid biopsies, the GG genotype of the CYP3A5 A6986G affects longer disease-free survival in DLBCL patients, highlighting the significance of circulating biomarkers for prognostic evaluation.
December 2023 in “Dermatologic Surgery” The researchers reported that using a skin-responsive FUE device in nonscalp hair transplantation significantly reduced graft transection rates compared to older methods, improving patient satisfaction and surgeon willingness.
October 2023 in “Materials chemistry and physics (Print)” Adding keratin to a mix of cow hair and plant-based plastic makes it stronger.
109 citations
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October 2007 in “American Journal of Human Genetics” This study found that postnatal treatment with recombinant EDA normalized adult teeth, improved sweating, and restored normal lacrimation in dogs with XLHED, suggesting its potential as a treatment for the condition.
95 citations
,
August 2022 in “JAMA Network Open” This study documented an increased health care burden due to post-COVID conditions in the 6 months following the acute phase of infection, providing vital evidence for resource planning.
66 citations
,
February 2002 in “Veterinary dermatology” This study suggests that the presence of Malassezia yeast in biopsy specimens from cats with multifocal or generalized skin lesions indicates the need for a thorough assessment for internal neoplasia.
64 citations
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December 2003 in “Veterinary Dermatology” This research observed that triamcinolone was more effective at inducing remission in cats with pemphigus foliaceus without significant side effects compared to prednisone or its combination with chlorambucil.
33 citations
,
September 2007 in “Veterinary dermatology” In this study, proliferative and necrotizing feline otitis externa in four domestic shorthair cats improved with topical 0.1% tacrolimus treatment, despite previous ineffective therapies.
24 citations
,
September 2023 in “Science Advances” In this study, deleting the gene Mettl3 in mouse epidermal progenitors resulted in impaired epithelial development and self-renewal, highlighting m6A's crucial role in regulating chromatin modifiers and maintaining normal epithelial tissue function.