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This study found that applying controlled hypobaric stress to the skin significantly improved the in vitro and in vivo penetration of macromolecules, facilitating enhanced drug delivery.

This review discusses recent advancements in using macromolecules for hair loss treatment, highlighting microneedle and nanoparticle delivery systems, tissue-engineered scaffolds for hair follicle regeneration, and artificial skin platforms as drug screening methods.

In this study, the authors found that applying hypobaric pressure to the skin significantly increases the transdermal permeation of large molecules by enhancing diffusion, despite the associated skin stretching and hair follicle enlargement not fully explaining this effect.

This study found that a newly constructed composite hydrogel dressing, made from silk fibroin, chitosan, and halloysite, promoted hair follicle neogenesis, angiogenesis tissue regeneration, and scar reduction.

This study reported that a newly developed hydrogel composed of recombinant type I collagen and chitosan, incorporating a metal–polyphenol structure, demonstrated strong mechanical and healing properties, effectively promoting wound healing in a full-thickness skin defect model.

In this comprehensive review, researchers reported that macromolecules like type I collagen, keratin, and ceramides enhance hair health by improving follicular function and increasing hair density, strength, shine, and resilience, as shown in various in vitro, animal, and human studies.

Glycogen helps E. coli cells divide unevenly and organize their contents.

This study introduces a novel in vitro model for clubfoot fibrosis to enable high-throughput drug screening and found that while the model increased collagen deposition, the antifibrotic drug minoxidil effectively inhibited the expression of collagen cross-linking enzymes.

This study found that goat placenta extract, when combined with PEGylated liposomes and microspicule gel, significantly promoted hair regrowth in patients experiencing hair loss due to chemotherapy by enhancing hair cell proliferation without causing skin irritation over a 12-week application period.

This review discusses current wound management strategies and examines electrospun nanofibers with biological macromolecules for their potential in tissue engineering and drug delivery, but reports no new clinical results.

This review discusses the roles and mechanisms of glycosaminoglycans in wound healing and presents challenges and potential applications for GAG-based biomaterials without reporting new experimental results.

This study found that fractional laser treatment significantly enhances the penetration and targeting of certain permeants, such as imiquimod and FD, to skin follicles, but not hydroquinone.

This review highlights that the combination of ultrasound and microneedles can enhance transdermal drug delivery by using physical and energy-driven mechanisms to improve drug penetration into deeper skin layers, with implications for precision medicine and chronic disease treatments.

This chapter reviews the hair follicle's role in drug and chemical penetration through the skin but does not present new experimental findings.

The researchers reported that yak hair fibers undergo macromolecular conformational changes and partial slippage of macromolecules during stretching, confirming this as the main stretching mechanism when the stretching ratio is large.

This study found that paclitaxel poliglumex induces significantly less and milder alopecia compared with standard taxanes in ovarian and breast cancer patients.

This study found that aged tritiated thymidine breaks down and incorporates into cytoplasmic macromolecules, not DNA, suggesting caution in its use.

This study found that temperature significantly affects the mechanical properties of rabbit hair fibers, with increased tensile strain and decreased breaking strength in humid conditions.

In this study, researchers developed a microfluidic-assisted technology to create dual-layer microspheres containing mesenchymal and epidermal cells, which efficiently induced hair follicle regeneration in mice, suggesting potential improvements for hair regeneration treatments in conditions like androgenetic alopecia.

In this review, the authors highlight a lack of understanding regarding the unique properties of Afro-textured hair, emphasizing the need for scientific collaboration to improve hair care practices and mitigate scalp issues.

In this in-vitro study, researchers found that shampoo-induced coacervates structurally resemble cationic polymers and contain anionic surfactants that may stimulate the scalp upon exposure to water.

This review discusses the structure and assembly of the cornified cell envelope in stratified squamous epithelial cells and various disorders leading to barrier defects, but reports no new findings.

This review outlines the mechanisms, applications, and development prospects of label-free imaging technologies in transdermal research and reports no new clinical results.

This study found that a bilayer wound dressing capable of releasing hydrogen sulfide promoted wound healing in rats by reducing inflammation, enhancing vascularization, and facilitating hair follicle regeneration.

This review discusses iontophoresis, low-frequency ultrasound, and microneedles for enhancing topical drug delivery in dermatological treatments and reports no clinical results; it emphasizes their mechanisms and potential uses.

This study found that using a combination of iontophoresis and liposomal delivery facilitated the effective intradermal administration of superoxide dismutase in rats, reducing oxidative skin damage from UV exposure.